研究解析致癌基因Src由β3介導的激活機制
...移。一般認爲c-Src常常是通過富含脯氨酸的序列結合在其SH3結構域上,從而誘發c-Src激活,而β3則不同,它利用的是R760GT762來激活的。但是由於缺少這方面的結構生物學信息,因此目前還不清楚RGT是如何結合上SH3結構域的,其中...
行業資訊;臨牀快報;腫瘤相關MultilocusSequenceTypingofEscherichiacoliO26:H11IsolatesCarryingstxinCanadaDoesNotIdentifyGeneticDiversity
...onalMicrobiologyLaboratoryCadhamProvincialLaboratory,Winnipeg,ManitobaBritishColumbiaCentreforDiseaseControl,Vancouver,BritishColumbiaProvincialLaboratory,SaskatchewanHealth,Saskatoon,SaskatchewanProvincialLaboratoryforPublicHealth,Edmonton,Alberta,CanadaABSTRACTMultilocussequencetypingof31stx-carry...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期TheH+-LinkedMonocarboxylateTransporter(MCT1/SLC16A1):APotentialTherapeuticTargetforHigh-RiskNeuroblastoma
...oxylatetransporterisoform1(MCT1/SLC16A1).WefoundelevatedMCT1mRNAlevelsinfreshneuroblastomabiopsysamplesthatcorrelatedpositivelywithriskoffataldiseaseandamplificationofthe“proto-oncogenic“transcriptionfactorMYCN.WefurtherinvestigatedMCTasapotentialtherapeutictargetinvitro.Theneuroblastomacellline...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第12期Identificationofhumanurinarytrefoilfactor1asanovelcalciumoxalatecrystalgrowthinhibitor
...of-flightMSandelectrosprayionization–quadrupole–time-of-flighttandemMSashumantrefoilfactor1(TFF1).Westernblotanalysisconfirmedthemassspectrometricproteinidentification.FunctionalstudiesofurinaryTFF1demonstratedthatitsinhibitorypotencywassimilartothatofnephrocalcin.TheinhibitoryactivityofurinaryT...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第12期高速逆流色譜在植物有效成分分離中的應用
...主成分,其分離速度完全可與HPLC相比較;還有學者也從大黃羥基蒽醌總苷元中分離了大黃酸、蘆薈大黃素、大黃素、大黃素甲醚、大黃酚等;用正己烷—乙酸乙酯—甲醇—水(9∶1∶5∶5)在1800r/min轉速下在70min內從掌葉大黃的根莖...
藥品天地;專業藥學;實驗技術;色譜技術;色譜分析實例OxidizedLow-DensityLipoproteinRetardstheGrowthofProliferatingCellsbyInhibitingNuclearTranslocationofCellCycleProteins
...nipeg,Manitoba,Canada;andtheDepartmentofMicrobiology(G.Z.),UniversityofTexasHealthScienceCenteratSanAntonio,TX.ABSTRACTObjective—Ourstudytestedthehypothesisthatthemitogeniceffectofoxidizedlow-densitylipoprotein(oxLDL)onvascularcellsmaybefurtherenhancedbythepresenceofcytokinesandgrowthfactorsknownt...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第4期高速逆流色譜在植物有效成分分離中的應用-國家自然科學基金資助項目
...主成分,其分離速度完全可與HPLC相比較;還有學者也從大黃羥基蒽醌總苷元中分離了大黃酸、蘆薈大黃素、大黃素、大黃素甲醚、大黃酚等;用正己烷—乙酸乙酯—甲醇—水(9∶1∶5∶5)在1800r/min轉速下在70min內從掌葉大黃的根莖...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文TheadaptormoleculesLATandSLP-76arespecificallytargetedbyYersiniatoinhibitTcellactivation
...H,atyrosinephosphatase.UsingsinglecellvideomicroscopyandFACSanalysis,hereweshowthatevenanaverageofoneYersiniaperTcellissufficienttoinhibitoralterTcellresponses.ThisefficientinhibitionistracedtospecifictargetingbyYopHoftheadaptorproteins,linkerforactivationofTcells(LAT)andSH2-domain–containingleuko...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第3期蘆薈大黃素
[中文名稱]蘆薈大黃素[英文名稱]Aloe-emodin[別 名]蘆薈瀉素Rhabarberone[化學名稱]9,10-Anthracenedione,1,8-dihydroxy-3-(hydroxymethyl)[分子式]C15H10O5;[分子量]270.23[物理性質]橙色針狀結晶(甲苯),熔點223~224°。易溶於熱乙醇。在乙醚及苯中呈...
藥品天地;專業藥學;中藥大全;中草藥有效成分MastCellsProtectMicefromMycoplasmaPneumonia
...ia,wehypothesizedthattheydefendagainstmycoplasmainfection.Thisstudyteststhishypothesisusingmastcell–deficientmice.Methods:ResponsestoairwayinfectionwithM.pulmoniswerecomparedinwild-typeandmastcell–deficientKitW-sh/KitW-shmiceandsham-infectedcontrolmice.MeasurementsandMainResults:Endpointsinclude...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2006年第173卷第2期