Podocytesaresensitivetofluidshearstressinvitro
...anizationoftheactincytoskeletonandactivatesspecifictyrosinekinasesthatarerequiredtowithstandfluidshearstress.【關鍵詞】glomerularfiltrationforceactincytoskeletonPODOCYTESAREEXPOSEDTORELEVANTmechanicalforces,arisingfromglomerularcapillarypressureandglomerularfiltration(12).Glomerularcapillarypre...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第10期UseofaLocked-Nucleic-AcidOligomerintheClamped-ProbeAssayforDetectionofaMinorityPfcrtK76TMutantPopulationofPlasmodiumfalciparum
...bacteriaalsorepresentsasignificantthreatfordebilitatedpatients(22).Asaconsequence,aneedexiststohaveafastandsensitivediagnostictesttoidentifyminoritypopulationsofresistantorganisms.Inordertoimprovetheefficacyofsuchagenotype-assisteddiagnosis,methodshavebeendevelopedtolowerthedetectionthresholdofminor...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期MultilocusDNASequenceComparisonsRapidlyIdentifyPathogenicMolds
...ficultorimpossiblewhenthesestructuresarenotobserved.WehypothesizedthatDNAsequenceanalysisofmultiplelociisusefulforrapidlyidentifyingmedicallyimportantmolds.OurstudyincludedtheanalysisoftheD1/D2hypervariableregionofthe28Sribosomalgeneandtheinternaltranscribedspacer(ITS)regions1and2oftherRNAoperon.Two...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期正視眼成人角膜面形狀係數的數學分析*
... 1.2.5角膜表面形狀係數數學模型的建立 根據Bennett’s錐形切面公式y2=2r0z-(1-e2)z2推導出e2=1-(2r0z-y2)/z2,並根據本研究所採集的正常人羣角膜頂點數據(曲率半徑及厚度),建立角膜前、後表面兩正交主子午線的形狀係數數學...
醫源資料庫;在線期刊;中華醫學研究雜誌;2011年第11卷第4期RegulationofperipheralTcellactivationbycalreticulin
...s.Indeed,defectsinnegativeregulatorymolecules,suchasphosphatases(2,3),E3ubiquitinligases(4,5),cellsurfacereceptors(6),andtranscriptionfactors(7,8),contributetothedevelopmentofimmunopathology.Defectsintheinductionofapoptosiswereshowntoaffectthedeletionofautoreactivecellsinthethymus,resultinginautoimm...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第2期DesignofNovelConformationalandGenotype-SpecificAntigensforImprovingSensitivityofImmunoassaysforHepatitisCVirus-SpecificAntibodies
...s(HCV)isthemajoretiologicagentforbloodtransfusion-associatedandcommunity-acquirednon-A,non-Bviralhepatitis(1,9,19).HCVcurrentlyaffectsapproximately3%oftheworld‘spopulation,and70%ofthoseindividualsdevelopchronicHCVinfection,whichoftenprogressestolivercirrhosisandhepatocellularcarcinomas(3,19,23).Th...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第8期Directevidencefortheroleofcaveolin-1andcaveolaeinmechanotransductionandremodelingofbloodvessels
...ofthesurfacemembrane,whicharemainlycomposedofphospholipids,theyhaveaveryuniquelipidcompositionenrichedincholesterolandsphingolipids.Amongthe3isoformsthathavebeendescribed(caveolin-1,Cav-2,andCav-3),Cav-1isthemajorcoatproteinofendothelialcaveolaeandisnecessaryforcaveolaeassembly.Indeed,severalstudies...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第5期NovelReplicon-BasedReporterGeneAssayforDetectionofRubellaVirusinClinicalSpecimens
...icassay.Theassaywassensitive,usinglaboratoryRUBstrainsandaslowadoseasoneplaque-formingunit.TheassaywasspecificinthatitwaspositiveforRUBstrainsofbothgenotypesandwasnegativeforapanelofhumanviruses.ItwasalsopossibletogeneticallysequencetheRUBpresentinpositiveclinicalspecimensdetectedintheassayforgenoty...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第2期Antiviraldefense:interferonsandbeyond
...icacidrecognitionintheinductionoftypeIinterferonproductionandraiseimportantquestionsregardingthenatureofcell-autonomousvirusdetectionincoordinatingtheantiviralresponse.D.B.S.andR.M.areatHowardHughesMedicalInstituteandSectionofImmunobiology,YaleUniversitySchoolofMedicine,NewHaven,CT06520.Virusesareth...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第8期Nonhumanprimatemodelsofasthma
...andiseasethatdoesnothaveanaccuratecounterpartinanycommonmodelorganism.Mostofourunderstandingoftheimmunemechanismsunderlyingasthmacomesfromstudiesinmanandmouse.However,therearefundamentaldifferencesbetweenthespontaneousdiseaseinmanandtheexperimentallyinducedcounterpartsinmice.Weadvocatemoreextensiveu...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第12期