DimerizationRegionofSolubleGuanylateCyclaseCharacterizedbyBimolecularFluorescenceComplementationinVivo
...GC.MultisequencealignmentofsGCandsubunitsfromthefollowingspecies(UniProtKB/Swiss-Protaccessionnumbersinparentheses):rat1(P19686),bovine1(P19687),human1(Q02108),mouse1(Q9ERL9),medakafish1(P79997),rat1(P20595),bovine1(P16068),human1(Q02153),mouse1(O54865),medakafish1(P79998),andDrosophilamelanogaster1...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第11期TheSphingosine-1-PhosphateAnalogueFTY720ReducesAtherosclerosisinApolipoproteinE-DeficientMice
...dstimulationofeNOSmayattenuateatherosclerosis,weadministeredFTY720toapolipoproteinE-/-micefedahigh-cholesteroldiet.MethodsandResults-FTY720dramaticallyreducedatheroscleroticlesionvolume(62.5%),macrophage(41.8%),andcollagencontent(63.5%)after20weeksofhigh-cholesteroldiet.Inisolatedaorticsegmentsandcu...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第3期RegionalDesensitizationof-AdrenergicReceptorSignalinginSwineWithChronicHibernatingMyocardium
...uctionwasnormal(LAD,87±18versus91±19pmol/mgperminute;P=NS),responsestoisoproterenolwereblunted(LAD,83±6versus146±25pmol/mgperminuteinremote;P0.05).-receptordensityandsubtypewereunchanged,buttherewasareductioninthenumberofhigh-affinitybindingsites(LAD,40±4%versus53±7%innormalremote;P0.05).TheGi...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第10期AssociationofOAZ1GenePolymorphismsWithSubclinicalandClinicalVascularEvents
...easurementsofCCA-IMTweremadeatasitefreeofanydiscreteplaques,anddetailsoftheprotocolhavebeendescribedelsewhere.20LongitudinalchangesinCCA-IMTwerecomputedasthedifferencebetweenthe4-yearfollow-upandbaselinevalues.ThemeanbaselineCCA-IMTwas0.665±0.120mm.Thestudysamplewascomposedof1001subjectswithf...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第10期Theeffectofsoyproteinwithorwithoutisoflavonesrelativetomilkproteinonplasmalipidsinhypercholesterolemicpostmenopausalwomen
...rialdataandtheresultsofameta-analysissuggestahypocholesterolemiceffectofsoyprotein.Theeffectmaybepartiallyattributabletotheisoflavonesinsoy.Fewstudieshaveexaminedtheseparateeffectsofsoyproteinandisoflavones.Objective:Theobjectiveofthisstudywastodeterminetheeffectofsoyproteinandisoflavonesonplasmalip...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2001年73卷第4期RoleofNuclearCa2+/Calmodulin-StimulatedPhosphodiesterase1AinVascularSmoothMuscleCellGrowthandSurvival
...Thisresultsinthecapacitytoproliferate,migrate,andproduceextracellularmatrixproteins,thuscontributingtoneointimalformation.Cyclicnucleotidephosphodiesterases(PDEs),byhydrolyzingcAMPorcGMP,arecriticalinthehomeostasisofcyclicnucleotidesthatregulateVSMCgrowth.Here,wedemonstratethatPDE1A,aCa2+-calmodulin...
醫源資料庫;在線期刊;循環研究雜誌;2006年第96卷第3期AldosteroneandAngiotensinIISynergisticallyInduceMitogenicResponseinVascularSmoothMuscleCells
...spironolactone.CombinedtreatmentwithAldoandAngIIattenuatedmitogen-activatedproteinkinasephosphatase-1(MKP-1)expressionandincreasedKi-ras2Aexpression.ThelateERKpeakwasnotobservedinVSMCtreatedwithKi-ras2A-siRNA.Interestingly,thedecreaseinMKP-1expressionandtheincreaseinKi-ras2AexpressionwererestoredbyP...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第9期Inverseassociationbetweentheeffectofcarbohydratesonbloodglucoseandsubsequentshort-termfoodintakeinyoungmen
...eandlemonconcentratewereaddedinanattempttomatchforsweetnessandpalatability.ProtocolSubjectschoseatimebetween0700and1000atwhichtoparticipateineachexperiment,andtheywereaskedtoarriveatthesametimeforeachsubsequentsession.Subjectsarrivedforeachsessionafteranovernight(1012h)fast.Waterwasallowedupto...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2002年76卷第5期NegativeRegulationofTRPC3ChannelsbyProteinKinaseC-MediatedPhosphorylationofSerine712
...anbeactivatedbythediacylglycerolanalog1-oleoyl-2-acetyl-sn-glycerol(OAG)inaproteinkinaseC-independentmanner.Ontheotherhand,phorbol12-myristate13-acetate(PMA)inhibitsOAG-mediatedTRPC3channelactivation,suggestingthatphosphorylationofTRPC3byproteinkinaseCisamechanismofreceptor-mediatednegativefeedback....
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第2期CathepsinGIsRequiredforSustainedInflammationandTissueInjuryafterReperfusionofIschemicKidneys
【摘要】Neutrophilactivationtoreleasegranulescontainingproteasesandotherenzymesisaprimarycauseoftissuedamageduringischemia/reperfusioninjury.Becausethecontributionofspecificgranuleenzymestothisinjuryremainspoorlydefined,theroleofcathepsinGinrenalischemia/reperfusioninjurywastested.Bilateralrenal...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第3期