Heme:adeterminantoflifeanddeathinrenaltubularepithelialcells
【摘要】Hemeoxygenase-1(HO-1)andp21influencecellfate,andgeneticHO-1overexpressionupregulatesp21andconfersresistancetoapoptosis.Thepresentstudyexaminedtheeffectsofheme,ametaboliteincriminatedinrenalinjury,onsensitivitytoapoptosisandcellgrowthinconjunctionwithcellularexpressionofHO-1andp21.Immorta...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第2期p21andmTERTarenovelmarkersfordeterminingdifferentischemictimeperiodsinrenalischemia-reperfusioninjury
...pregulatestress-inducedgenes,suchasthecyclin-dependentkinase(CDK)inhibitorp21.Sofar,theexpressionandroleofCDKinhibitors,aswellasmousetelomerasereversetranscriptase(mTERT),hasnotbeeninvestigatedinamodelwithvariablelastingischemicperiods.MaleC57Bl/6miceweresubjectedtorenalischemiareperfusioninjurybycl...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第2期Protectionofrenalcellsfromcisplatintoxicitybycellcycleinhibitors
...hecellcycleaftercisplatinadministrationbutthatcellcycle-inhibitoryproteinsp21and14-3-3arealsoupregulated.Theseproteinscoordinatethecellcycle,anddeletionofeitherofthegenesresultedinincreasednephrotoxicityinvivoorincreasedcelldeathinvitroafterexposuretocisplatin.However,itwasnotknownwhethercellcyclein...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第2期CharacterizationofmarginalzoneBcellprecursors
...sisproposedtooccurbywayofproliferativeintermediatesexpressinghighlevelsofCD21/35andCD23.However,weshowthatCD21/35highCD23+splenocytesarenotenrichedforproliferativecells,anddonotcontributesubstantiallytothegenerationoffollicularBcells.Instead,ontogenicrelationships,steady-statelabelingkinetics,andado...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第9期血清CEA、CY211、NSE檢測對原發性肺癌治療後復發的診斷價值
【摘要】目的探討癌胚抗原(CEA)、細胞角蛋白19片段(CY211)、神經特異性烯醇化酶(NSE)3種標誌物對原發性肺癌治療後復發的診斷指導意義。方法回顧性分析我院2000—2005年268例原發性肺癌患者的CEA、CY211和NSE濃度變化。結果肺鱗...
醫源資料庫;在線期刊;濱州醫學院學報;2009年第32卷第5期p53、p21WAF1及MDM2蛋白在NKT細胞淋巴瘤中的關係及意義
...的蛋白在NK/T細胞淋巴瘤中的關係及意義。方法選用p53、p21WAF1及MDM2抗體做免疫組織化學SABC染色。結果35例病例中,p53蛋白陽性率爲51.4%(18/35);MDM2蛋白陽性率爲22.9%(8/35);p21WAF1蛋白陽性率爲48.6%(17/35)。p53+/p21+和p53-/p21-兩組病...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2004年第2卷第10B期血清CYFRA21-1值測定對鼻咽癌診斷及療效觀察的臨牀價值
【摘要】目的探索血清CYFRA21-1值測定對鼻咽癌(NPC)診斷及療效觀察的臨牀價值。方法應用電化學發光免疫分析技術測定未經治療的NPC患者(45例)和治療後的NPC患者(32例)的血清CYFRA21-1值,並分別與正常人(28例)血清CYFRA21-1...
醫源資料庫;在線期刊;中華現代耳鼻喉雜誌;2004年第1卷第1期MicroRNAsAreAberrantlyExpressedinHypertrophicHeart
...urseoftheaberrantmiRNAexpressionwasfurtheridentifiedinmouseheartsat7,14,and21daysafteraorticbanding.NineteenofthemostsignificantlydysregulatedmiRNAswerefurtherconfirmedbyNorthernblotand/orreal-timepolymerasechainreaction,inwhichmiR-21wasstrikingbecauseofitsmorethanfourfoldincreasewhencomparedwiththe...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第6期Useofashort-termisotope-dilutionmethodfordeterminingthevitaminAstatusofchildren
...ritionResearchCenteronAgingatTuftsUniversity,711WashingtonStreet,Boston,MA02111.E-mail:gtang{at}hnrc.tufts.edu.ABSTRACTBackground:AfteradoseoflabeledvitaminAisgiventohumansforestimatingbodystoresofvitaminA,bloodiscustomarilydrawnatpseudo-equilibrationtimesrangingfrom11to26d.Objective:Theobjectivewas...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2002年76卷第2期S-Glutathiolationofp21rasbyPeroxynitriteMediatesEndothelialInsulinResistanceCausedbyOxidizedLow-DensityLipoprotein
...dglutathionemimickedtheeffectsofoxLDL.OxLDLincreasedtheS-glutathiolationofp21ras,andadenoviraltransfectionwitheitheramutantp21ras(C118S)lackingthepredominantsiteofS-glutathiolationoradominant-negativemutantrestoredinsulin-inducedAktphosphorylation.Therequirementforoxidant-mediatedS-glutathiolationan...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第11期