Cyclooxygenases,microsomalprostaglandinEsynthase-1,andcardiovascularfunction
...sylvania,USA.2DepartmentsofPhysiologyandBiochemistry,Queen’sUniversity,Kingston,Ontario,Canada.AbstractWeinvestigatedthemechanismsbywhichinhibitorsofprostaglandinG/Hsynthase-2(PGHS-2;knowncolloquiallyasCOX-2)increasetheincidenceofmyocardialinfarctionandstroke.Theseinhibitorsarebelievedtoexertbotht...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第5期SuppressionofActivationofSignalTransducerandActivatorofTranscription-BSignalingintheVesselWallReducesBalloonInjury-InducedNeointimaFormatio
...VSMC)growthandmotility.TolearnmoreabouttheroleofSTAT-5Binvesselwallremodeling,weexamineditsinvolvementinplatelet-derivedgrowthfactor-BB(PDGF-BB)-stimulatedVSMCgrowthandmotilityandballooninjury-inducedneointimaformation.PDGF-BBactivatedSTAT-5Basmeasuredbyitstyrosinephosphorylation,DNAbinding,andrepor...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第10期RegulationofLysophosphatidicAcidReceptorExpressionandFunctioninHumanSynoviocytes:ImplicationsforRheumatoidArthritis?
...calconditions.ExtracellularLPAismainlyproducedbytheenzymeautotaxin(ATX).Usingfibroblast-likesynoviocytes(FLS)isolatedfromsynovialtissuesofpatientswithrheumatoidarthritis(RA),westudiedtheexpressionprofileofLPAreceptors,LPA-inducedcellmigration,andinterleukin(IL)-8andIL-6production.WereportthatFLSexpr...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第2期RelationshipsamongCD14andCC16Genotypes,PlasmaLevels,andSeverity
...ustralia,AustraliaABSTRACTRationale:Themajorityofpreviousstudiesinvestigatingasthmageneticshavefocusedoncohortswithstablediseaseandhavenotdefinedmechanismsimportantduringacuteasthma.CD14andCC16eachplayakeyroleinbiologicallyimportantinflammatorypathwaysandthegeneofeachhasafunctionalpromoter-regionpol...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2006年第173卷第6期ExpressionofCOX-2inplatelet-monocyteinteractionsoccursviacombinatorialregulationinvolvingadhesionandcytokinesignaling
...ity,Utah,USA.AbstractTightregulationofCOX-2expressionisakeyfeaturecontrollingeicosanoidproductioninatherosclerosisandotherinflammatorysyndromes.Adhesiveinteractionsbetweenplateletsandmonocytesoccurintheseconditionsanddeliverspecificsignalsthattriggerinflammatorygeneexpression.Usingacellularmodelofmo...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第10期精漿彈性蛋白酶水平與精液生化參數相關性探討
【摘要】200ng/ml)佔34.77%。精漿PMN-Elastase水平隨生殖系感染嚴重程度而升高,而果糖、中性α-葡糖苷酶、酸性磷酸酶、鋅的水平則隨之降低,呈負相關。結論PMN-Elastase水平隨生殖系感染嚴重程度而升高,精子生成的內環境受到影...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2008年第8卷第4期Theneutrophil-activatingproteinofHelicobacterpyloripromotesTh1immuneresponses
...ariaCareggi,Florence,Italy.AbstractTheHelicobacterpylorineutrophil-activatingprotein(HP-NAP)isavirulencefactorofH.pylorithatstimulatesinneutrophilshighproductionofoxygenradicalsandadhesiontoendothelialcells.WereportherethatHP-NAPisaTLR2agonistabletoinducetheexpressionofIL-12andIL-23byneutrophilsandm...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第4期ActivationofInflammationandCoagulationAfterInfusionofC-ReactiveProteininHumans
...omboticdisease.Sevenmalevolunteersreceivedaninfusionontwooccasions,containing1.25mg/kgrecombinanthumanCRP(rhCRP)ordiluent,respectively.CRP-concentrationsroseafterrhCRP-infusionfrom1.9(0.3to8.5)to23.9(20.5to28.1)mg/L,andsubsequentlybothinflammationandcoagulationwereactivated.Thissequenceofeventssugge...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第4期老年人地高辛的臨牀應用及監護
...年心衰時建議以每日0.125mg爲宜,最佳血藥濃度爲0.5~1.4ng/ml。結論在使用地高辛時要進行血藥濃度檢測。關鍵詞地高辛中毒監護地高辛的治療安全範圍較小,一般治療量已接近中毒量的60%。吸收率個體差異較大,而且廠家、批號...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2004年第2卷第6A期CholesterolAccumulationIsIncreasedinMacrophagesofPhospholipidTransferProtein-DeficientMice
...ophage-derivedPLTPwouldbeantiatherogenic.Thepresentstudyaimedatcharacterizingtheatheroprotectivepropertiesofmacrophage-derivedPLTP.MethodsandResults—PeritonealmacrophageswereisolatedfromPLTP-deficientandwild-typemiceandtheirbiochemicalcharacteristicswerecompared.Itisshownthatmacrophagesisolate...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第11期