Deathbegetsfailureintheheart
...NewYork10461,USA.Phone:(718)430-2609;Fax:(718)430-8989;E-mail:kitsis@aecom.yu.edu.AbstractRecently,low—butabnormal—ratesofcardiomyocyteapoptosishavebeenobservedinfailinghumanhearts.Geneticandpharmacologicalstudiessuggestthatthiscelldeathiscausallylinkedtoheartfailureinrodentmodels.Herein,werevie...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期GeneticCharacteristicsofHumanEnterovirus71andCoxsackievirusA16Circulatingfrom1999to2004inShenzhen,People‘sRepublicofChina
...10).Thus,theEV71genotypesoftheseHFMDepidemicsseemtoberegionallyandtemporallyunrestricted.Wecomparedtheavailablepublisheddatafor9EV71strainsdetectedfromtheChinesemainlandwiththe19sequencesdeterminedinthisstudy.These28EV71strainsweredetectedfromShenzhen,Shanghai,andChongqiduringtheyears1998to2004,excl...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第8期PrelaminAandlaminAappeartobedispensableinthenuclearlamina
...estthatthephysiologicfunctionofprelaminA,whateveritmightbe,couldberelativelyunimportantcomparedtotheseverediseasephenotypeselicitedbyanaccumulationoffarnesyl–prelaminA.Thus,fromtheperspectiveofapatientwithprogeria,livingwithoutprelaminAmightbequitepreferabletolivingwithit.InZmpste24–/–mice,far...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期Cholinergicstimulationblocksendothelialcellactivationandleukocyterecruitmentduringinflammation
...cisemechanismbywhichnicotineinhibitsinflammationinthesemodelsisnotcompletelyunderstood.Wangandcoworkers(5)recentlyidentifiedthe7nAChRexpressedbymacrophagesasthetargetofantiinflammatorycholinergicmediators,includingnicotine.Interestingly,the7nAChRreceptorhasbeenimplicatedininflammationinchronicinflam...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第7期EndogenoushumancytomegalovirusgBispresentedefficientlybyMHCclassIImoleculestoCD4+CTL
...tionmustbetemperedbythefactthatantigenpresentationwasmeasuredindirectlyandbyusingTcellclonesthatwereselectedforgBrecognition.However,coupledwiththeresultsinFig.7,ourobservationsareconsistentwiththeconclusionthatHis16cellscanpresentendogenousgBveryefficientlyascomparedwithprofessionalAPCs.Endogenousp...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第8期EnhancedBCellExpansionSurvivalandHumoralResponsesbyTargetingDeathReceptor6
...encesinBcellturnoverinnaiveDR6-/-andWTmicewereobservedasmeasuredbybromodeoxyuridineincorporation(unpublisheddata).Together,thesedatasuggestthattargeteddisruptionofDR6causesnogrossdefectsinBcelllineagedevelopmentorperipheralpopulations.BCellSurfaceExpressionofDR6.Previously,itwasshownthatDR6transcrip...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第1期Type2immunityiscontrolledbyIL-4/IL-13expressioninhematopoieticnon-eosinophilcellsoftheinnateimmunesystem
...valuationofthemechanismsbywhichtype2immunityisestablishedandrevealpreviouslyunrecognizedcellularinteractionsbetweeninnateandadaptivecells.ThesourceofIL-4,whicheffectivelymediatesTh2differentiationinvitroandsupportsTh2differentiationinvivo,hasbeenlongdebated,withvariousstudiessupportingrolesforautocr...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第6期EnhancedBCellExpansion,Survival,andHumoralResponsesbyTargetingDeathReceptor6
...encesinBcellturnoverinnaiveDR6-/-andWTmicewereobservedasmeasuredbybromodeoxyuridineincorporation(unpublisheddata).Together,thesedatasuggestthattargeteddisruptionofDR6causesnogrossdefectsinBcelllineagedevelopmentorperipheralpopulations.BCellSurfaceExpressionofDR6.Previously,itwasshownthatDR6transcrip...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第1期Carbonmonoxideameliorateschronicmurinecolitisthroughahemeoxygenase1–dependentpathway
...colitisinTh1-mediatedmurinemodels,suchasIL-10–/–mice(19),andarecurrentlyunderclinicalevaluationinCD(20).Accordingly,akintoacutetissueinjury,changesincytokineprofileinducedbyCOmaybebeneficialinchronicinflammation.Inthisstudy,wedemonstratethatCOadministrationameliorateschronicintestinalinflammatio...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第12期Expansionandlong-rangedifferentiationoftheNKTcelllineageinmiceexpressingCD1dexclusivelyoncorticalthymocytes
...anddifferentiation,butthenatureandsequenceoftheseinteractionsremainpartiallyunderstood.AfterpositiveselectionmediatedbyCD1d-expressingcorticalthymocytes,thematureNKTcelllineageundergoesaseriesofchangessuggestingantigenprimingbyaprofessionalantigen-presentingcell,includingextensivecelldivision,acquis...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第2期