ReversalofexperimentalpulmonaryhypertensionbyPDGFinhibition
...ryarterialhypertension(IPAH)isalife-threateningdiseasecharacterizedbyamarkedandsustainedelevationofpulmonaryarterypressure.ThediseaseresultsinRVfailureanddeath(1).Currenttherapeuticapproachesforthetreatmentofchronicpulmonaryhypertensionmainlyprovidesymptomaticrelief,aswellassomeimprovementofprognosi...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期IncreasedNHE1expressionisassociatedwithserumdeprivation-induceddifferentiationinimmortalizedratproximaltubulecells
...othtranscriptionandtranslationoftheantiporter,astheutilizationofactinomycinDandcycloheximidesignificantlyinhibitedtheupregulationofNHE1inducedbyserumwithdrawal.Inhibitionoftyrosinephosphorylationbygenisteinblockedtheserumdeprivation-dependentactivationofNHE.Moreover,thepharmacologicalinhibitionofMEK...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第7期第三節 載脂蛋白基因的多態性
...naturinggradientgelelectrophoresis,DGGE)顯示由基因編碼胺基酸區DAN序列突變所致的單股DNA構象的多態性;或使用等位基因特異的寡核苷酸探針雜交法(allele-specificoligonucleotidehybridization,ASO)探測突變的等位基因;或測定限制性片段長...
醫源資料庫;醫源圖書館;教材類;動脈粥樣硬化TAT-mediatedintracellulardeliveryofpurinenucleosidephosphorylasecorrectsitsdeficiencyinmice
...modelsorpatientshasnotpreviouslybeendescribed.WefusedhumanPNPtotheHIV-TATPTDandfoundthatthefusionwithTATchangedtheretentionanddistributionofPNPinPNP-deficientmice.TATinducedrapidintracellulardeliveryofPNPintotissues,includingthebrain,preventedurinaryexcretionofPNP,andprotectedPNPfromneutralizinganti...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第10期Contributionofpostprandiallipemiatothedietaryfat-mediatedchangesinendogenouslipoprotein-cholesterolconcentrationsinhumans
...oSFAs(P:S)=2.0]andSFA-rich(P:S=0.25)dietsonfastingandpostprandialplasmalipidandlipoprotein-cholesterolconcentrationsin16normolipidemicsubjects.Results:FastingplasmacholesteroldecreasedsignificantlyafteraPUFA-richdietbecauseofadecreaseinLDL(12.3%;P0.05)andHDL(3.8%;NS),butdidnotchangeafter...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2004年80卷第5期GenomicandBioinformaticsAnalysesofHAdV-4vacandHAdV-7vac,TwoHumanAdenovirus(HAdV)StrainsThatConstitutedOriginalProphylaxisagainstHAdV-Related
...6).Bioinformaticsandcomparativewhole-genomeanalyseswiththeirrecentlyreportedandarchivedprototypegenomesrevealsixmismatchesandfourinsertions-deletions(indels)betweentheHAdV-4prototypeandvaccinestrains,incontrasttothe611mismatchesand130indelsbetweentheHAdV-7prototypeandvaccinestrains.Annotationreveals...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期GlycogenSynthaseKinase3RegulatesN-Methyl-D-aspartateReceptorChannelTraffickingandFunctioninCorticalNeurons
...torsinducedthedown-regulationofNMDARcurrentthroughincreasingtheRab5-mediatedandPSD-95-regulatedNMDARinternalizationinaclathrin/dynamin-dependentmanner.Glycogensynthasekinase3(GSK-3)wasinitiallyidentifiedasanenzymethatregulatesglycogensynthesisinresponsetoinsulin(Welshetal.,1996).Twodistinctbutclosel...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第7期RegulationofCD1dexpressionandfunctionbyaherpesvirusinfection
...onse,mostnotablyNKcells,whichcanrecognizeandkillinfectedcellsandreleaseabundantquantitiesofantiviralcytokines(2).Additionally,TcellsthatarerestrictedbyCD1molecules—afamilyofantigen-presentingmoleculesdistantlyrelatedtoclassImoleculesoftheMHC—mayalsoparticipateinearlyhostresponses(3).UnlikeMHC-en...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第5期Decorin-MediatedRegulationofFibrillin-intheKidneyInvolvestheInsulin-LikeGrowthFactor-IReceptorandMammalianTargetofRapamycin
....24-26Inlinewiththesefindings,transforminggrowthfactor-ßantagonistsandangiotensinIIreceptorblockerhaverecentlybeenshowntopreventaorticaneurysmsinamousemodelofMarfan??ssyndrome.27Interestingly,inbullouskeratopathystromalcells,bothtransforminggrowthfactor-ßandIGF-Imodulatethesynthesisoffib...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第1期InvasiveInfectionsCausedbyTrichosporonSpeciesandGeotrichumcapitatuminPatientswithHematologicalMalignancies:aRetrospectiveMulticenterStudyfro
...Turin,Bergamo,Udine,andBologna),sixwereincentralItaly(inFlorence,Pescara,andAnconaandinthreecentersinRome),andfourwereinsouthernItaly(inNaples,ReggioCalabria,Bari,andSanGiovanniRotondo).Ineachcenter,allinvasiveinfectionscausedbyTrichosporonsp.orG.capitatumobservedinpatientswithhematologicmalignancie...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期