pCipProtectionagainstHyperoxiaRequiresBcl-XLandIsUncoupledfromItsAbilitytoSuppressGrowth
【摘要】Thecyclin-dependentkinaseinhibitorp21Cip1/Waf1/Sdi1protectsthelungagainsthyperoxia,butthemechanismofprotectionremainsunclearbecauselossofp21doesnotleadtoaberrantcellproliferation.BecausesomemembersoftheBcl-2genefamilyhavebeenimplicatedinhyperoxia-inducedcelldeath,thecurrentstudyinvestiga...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第6期CCLExpressionPatternofHumanSecondaryLymphoidOrganStromaIsConservedinInflammatoryLesionswithLymphoidNeogenesis
【摘要】CCL21isahomeostaticlymphoidchemokineinstrumentalintherecruitmentandorganizationofTcellsanddendriticcellsintolymphoidTareas.Inhumansecondarylymphoidorgans(SLOs),CCL21isproducedbycellsdistributedthroughouttheTzone,whereashighendothelialvenules(HEVs)lackCCL21mRNA.Acriticalquestionremainswhe...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第11期FGF-21asanovelmetabolicregulator
...population.Herewedescribeapotentialnoveltherapeuticagentforthisdisease,FGF-21,whichwasdiscoveredtobeapotentregulatorofglucoseuptakeinmouse3T3-L1andprimaryhumanadipocytes.FGF-21–transgenicmicewereviableandresistanttodiet-inducedobesity.TherapeuticadministrationofFGF-21reducedplasmaglucoseandtriglyc...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第6期Inhibitionofp21modifiestheresponseofcorticalproximaltubulestocisplatininrats
【摘要】Thepurposeofthisstudywastoevaluatewhetherupregulatedp21,acellcycle-inhibitoryprotein,contributestocisplatin(CDDP)-inducedacuterenalfailure(ARF)andtoacquiredresistancetorechallengeinjurywithCDDPinrats.ARFwasinducedinratsbyinjectionofCDDP(5mg/kg)andrechallengeinjurytoCDDPbythesamedoseofCDD...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第7期pCipIsRequiredfortheDevelopmentofMonocytesandTheirResponsetoSerumTransfer-inducedArthritis
...摘要】Oneofthecentralfunctionsofcyclin-dependentkinaseinhibitors,suchasp21,p27,orp16,istoprevententryintothecellcycle.However,thequestionremainsastowhethertheyhaveotherfunctionsinthecell.Wepreviouslydemonstratedthatoverexpressionofp21infibroblastsisolatedfrompatientswithrheumatoidarthritisdecreas...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第5期Identificationofthefunctionaldomainofp21WAF1/CIP1thatprotectscellsfromcisplatincytotoxicity
...cine,UniversityofArkansasforMedicalSciences,LittleRock,ArkansasABSTRACTThep21cyclin-dependentkinase(cdk)inhibitorprotectscellsfromcisplatincytotoxicityinvivoandinvitro.However,themechanismofprotectionisnotknown.Separatep21domainsareknowntointeractwithseveraldifferentproteinshavingproapoptoticfunctio...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第10期SynergyofIL-21andIL-15inregulatingCD8+Tcellexpansionandfunction
...CancerInstitute,NationalInstitutesofHealth,Bethesda,MD20892Interleukin(IL)-21isthemostrecentlyrecognizedofthecytokinesthatsharethecommoncytokinereceptorchain(c),whichismutatedinhumanswithX-linkedseverecombinedimmunodeficiency.WenowreportthatIL-21synergisticallyactswithIL-15topotentlypromotetheprolif...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第1期EB病毒相關胃癌組織中P53及P21蛋白的表達
[摘要]目的探討EpsteinBarr病毒(EBV)感染、P53和P21蛋白表達異常在胃癌發生發展中的作用以及三者相關性。方法應用免疫組化技術檢測13例EBV相關胃癌(EBVaGCs)、45例臨牀指標與之匹配的EBV陰性胃癌(EBVnGCs)以及58例相應癌...
醫源資料庫;在線期刊;齊魯醫學雜誌;2006年第21卷第1期P21WAF1蛋白和層粘連蛋白(LN)在結節性甲狀腺腫中的表達
【摘要】目的研究P21WAF1蛋白和層粘連蛋白(LN)在結節性甲狀腺腫中的表達水平及意義。方法應用免疫組化SP法檢測50例結節性甲狀腺腫、40例正常甲狀腺組織、40例甲狀腺癌標本中P21WAF1蛋白和LN的表達。結果P21WAF1蛋白和LN表達陽...
合作平臺;在線期刊;中華實用醫藥雜誌;2004年第4卷第16期;論著SequentialactivationofNKTcellsandNKcellsprovideseffectiveinnateimmunotherapyofcancer
...ralia3DepartmentofImmunology,JuntendoUniversitySchoolofMedicine,Tokyo113-8421,Japan4DepartmentofMicrobiologyandImmunology,UniversityofMelbourne,Parkville,Victoria3010,AustraliaTheCD1dreactiveglycolipid,-galactosylceramide(-GalCer),potentlyactivatesTcellreceptor-typeIinvariantNKTcellsthatsecondarilys...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第12期