Trans-cyclopropanationofmycolicacidsontrehalosedimycolatesuppressesMycobacteriumtuberculosis–inducedinflammationandvirulence
...icacidsbutsynthesizesintactratiosofallmycolicacidsubclasses(30).WeinfectedC57BL/6JandBALB/CmicewithWTM.tuberculosis,acmaA2nullmutant,andageneticallycomplementedcmaA2mutantcarryingasinglecopyofWTcmaA2expressedfromitsnativepromoter.BothBALB/CandC57BL/6Jmicereceivedeither100CFUsbyaerosolor105or106CFUsb...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第6期IL-20IsExpressedinAtherosclerosisPlaquesandPromotesAtherosclerosisinApolipoproteinE-DeficientMice
...ionofIL-20anditsreceptorsintheatheroscleroticlesionsinapoE-/-miceandnormalC57BL/6mice.WefoundthatIL-20wasupregulatedintheatherosclerosisplaqueofapoE-/-micecomparedwithnormalC57BL/6mice(supplementalFigureIAitoAj,availableonlineathttp://atvb.ahajournals.org).StrongimmunoreactivitywasdetectedforbothIL-...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第9期TheroleofherpesvirusentrymediatorasanegativeregulatorofTcell–mediatedresponses
...hecompletecodingsequencefortheextracellulardomain.(D)BloodwascollectedfromC57BL/6(WT)andHVEM–/–mice,andwhitebloodcellswerestainedwithbiotin-labeledratanti-HVEMmAbandstreptavidin-CyChrome.(E)LymphnodecellsfromWTandHVEM–/–micewerestainedwithPE–anti-CD3,biotin-labeledratanti-HVEMantibody,ands...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期H-2Kb基因轉移誘導小鼠心肌移植免疫耐受
...過逆轉錄病毒載體介導的基因轉移技術,將供體小鼠(C57BL/6)的H-2Kb基因(小鼠MHC-Ⅰ類基因)導入到受體小鼠(BALB/c)的造血細胞。結果 H-2Kb基因可以穩定地整合進小鼠造血細胞的基因內,並在受體內表達較長時間。正常...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學IL-2在體內抗弓形蟲作用機制的研究
...。 1 材料和方法 1.1 實驗動物、蟲株及細胞 C57BL/6純系雌性小鼠6~8周齡,購自白求恩醫科大學實驗動物部,經PCR檢測試劑盒檢測爲弓形蟲陰性;弓形蟲RH株,爲常用標準強毒株,小鼠腹腔傳代;Yac-1細胞,白求恩醫...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學Minimummethioninerequirementandcysteinesparingofmethionineinhealthyschool-agechildren
...rogenbalanceofwomenmaintainedonvariouslevelsofmethionineandcysteine.JNutr1957;64:99111.DiBuonoM,WykesLJ,BallRO,PencharzPB.Dietarycysteinereducesthemethioninerequirementinmen.AmJClinNutr2001;74:7616.KurpadAV,ReganMM,VaralakshmiS,GnanouJ,LingappaA,YoungVR.Effectofcysteineonthemethioninereq...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年84卷第5期BovineLactoferricinInhibitsBasicFibroblastGrowthFactor-andVascularEndothelialGrowthFactor-InducedAngiogenesisbyCompetingforHeparin-LikeBindin
...inhibitedbothbFGF-andVEGF165-inducedangiogenesisinMatrigelplugsimplantedinC57BL/6mice.Inaddition,LfcinBinhibitedtheinvitroproliferationandmigrationofhumanumbilicalveinendothelialcells(HUVECs)inresponsetobFGForVEGF165butwasnotcytotoxictoHUVECs.Rather,LfcinBcomplexedwithheparin-likestructuresontheHUVE...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第11期EffectofHepatitisCVirusGenotypeonCD4+TCellCountinaCohortofAntiretroviral-NaiveHIV-1InfectedIndividuals
...4(P=.02,Kruskal-Wallistest);themean(±SD)follow-upperiodforallpatientswas4.57(8.33)months.Riskcategorieswereinjectiondruguse(255[84.4%]patients),homosexualcontact(11[3.6%]patients),andheterosexualcontact(27[8.9%]patients).Inourbasicmodelthatadjustedforagealone,absoluteCD4+Tcellcountsweresignificantl...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第16期RoleofatyrosinekinaseintheCO2-inducedstimulationofHCO3-reabsorptionbyrabbitS2proximaltubules
...n(solution4,5,or6)containinggenistein(345834,Calbiochem,LaJolla,CA);PP2(529573,Calbiochem);PD168393(513033,Calbiochem);orBPIQ-I(203696,Calbiochem)plus1:20,000DMSO(D-5534,Sigma,St.Louis,MO).Wethenrepeatedtheprocedureoutlinedforthefirstcollectionperiods.WegeneratedOOECO2/HCO3-solutions(solution5and6)b...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第8期替米沙坦聯合硝酸酯類治療慢性心力衰竭63例臨牀觀察
...分爲治療組與對照組。治療組63例,男39例,女24例;年齡57~76歲,平均66歲;心功能均Ⅳ級;肺心病43例,冠心病12例,高心病8例。對照組63例,男38例,女25例;年齡56~74歲,平均65歲;心功能Ⅲ級41例,Ⅳ級22例;肺心病40例,冠心病14...
醫源資料庫;在線期刊;中華現代內科學雜誌;2009年第6卷第7期