成骨骼肌細胞心臟移植治療缺血性心臟病和心臟衰竭的過去,現在和未來
...失常藥物(amiodarone)的應用,沒有心律失常的報道。Chachques等也證實,自體血清作爲培養成骨骼肌細胞的基質可以避免心律失常的發生[57]。 除了附屬於冠脈搭橋手術,成骨骼肌細胞移植也在接受左心輔助裝置(LVAD)的患者...
醫源資料庫;在線期刊;中華醫學研究雜誌;2005年第5卷第11期ProangiogenicEffectsofProtease-ActivatedReceptor2AreTumorNecrosisFactor-andConsecutivelyTie2Dependent
...roinflammatoryeffects,suchthatinretinalvasculature,theydependonTNF-andsubsequentinductionoftie2viatheMEK/ERKpathway.ThisarticleinvestigatedPAR2activationinretinalangiogenesis.TNF-inhibitors(infliximabandetanercept)andtheMEKinhibitorPD98059preventedtie2upregulation,endotheliumproliferation,andretinal...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第4期DistinctDiversityofvacA,cagA,andcagEGenesofHelicobacterpyloriAssociatedwithPepticUlcerinJapan
...icaloutcome,weselectedH.pyloristrainswithvariousgenotypesofvacAinJapanandsequencedfull-lengthvacA,cagA,andcagEgenes.SequencingofvacAandcagAgenesrevealedvariablesize,whereasthecagEgenewaswellconservedamongstrains.EachofthephylogenetictreesbasedonthededucedaminoacidsequencesofVacA,CagA,andCagEindicate...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第8期MurineModelstoEvaluateNovelandConventionalTherapeuticStrategiesforCancer
...everalanimalmodels,inadditiontolimitationsandaneedforimprovement.Modelinadequaciesincludeexperimentaldesignsthatdonotincorporatebiologicalconcepts,drugpharmacology,ortoxicity.Ascitesmodelshavebeenfoundtoidentifydrugsactiveagainstrapidlydividingtumors;however,neitherasciticnortransplantablesubcutaneo...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第3期CorrelationbetweenImmunologicResponsestoaRecombinantGlycoprotein120VaccineandIncidenceofHIV-1InfectioninaPhase3HIV-1PreventiveVaccineTri
...aceborecipients,n=1805),bindingandneutralizingantibodyresponsestorgp120werequantitated.Acase-cohortdesignwasusedtostudycorrelationsbetweenantibodylevelsandHIV-1incidence.Results.PeakantibodylevelsweresignificantlyinverselycorrelatedwithHIV-1incidence.Therelativerisk(RR)ofinfectionwas0.63(95%confiden...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第5期Leptinactionintheforebrainregulatesthehindbrainresponsetosatietysignals
...ton,USA.AbstractThecapacitytoadjustenergyintakeinresponsetochangingenergyrequirementsisadefiningfeatureofenergyhomeostasis.Despitetheidentificationofleptinasakeymediatorofthisprocess,themechanismwherebychangesofbodyadiposityarecoupledtoadaptive,short-termadjustmentsofenergyintakeremainspoorlyunderst...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期Reversalofdiet-inducedhepaticsteatosisandhepaticinsulinresistancebyantisenseoligonucleotideinhibitorsofacetyl-CoAcarboxylases1and2
...ctonlipogenesis.InratswithNAFLD,suppressionofbothenzymeswithasingleASOwasrequiredtosignificantlyreducehepaticmalonyl-CoAlevelsinvivo,lowerhepaticlipids(long-chainacyl-CoAs,diacylglycerol,andtriglycerides),andimprovehepaticinsulinsensitivity.Plasmaketonesweresignificantlyelevatedcomparedwithcontrolsi...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期ThenuclearfactorHMGB1mediateshepaticinjuryaftermurineliverischemia-reperfusion
...ediatorofinflammationandcellinjuryafterhepaticI/RandthattheactionsofHMGB1requireTLR4.WeshowthatHMGB1isup-regulatedinculturedhepatocytesbyhypoxiaandwarmhepaticI/Rinvivo.NeutralizingantibodytoHMGB1preventshepatocellulardamageandsuppressestheactivationofinflammatorycascades.Inaddition,weshowthattheTLR4...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第7期ThestructureofhumanCD23anditsinteractionswithIgEandCD21
...fMolecularBiophysics,DepartmentofBiochemistry,UniversityofOxford,OxfordOX13QU,England,UK2RandallDivisionofCellandMolecularBiophysics,King‘sCollegeLondon,LondonSE11UL,England,UK3DepartmentofMedicine,HealthScienceCenter,UniversityofColorado,Denver,CO802624DepartmentofImmunology,HealthScienceCenter,U...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第6期TransformingGrowthFactor-1ImpairsEndothelin-1-MediatedContractionofBrainVesselsbyInducingMitogen-ActivatedProtein(MAP)KinasePhosphatase-1andI
...swerethenpressurized(60mmHg),superfusedwithKrebs,andallowedtostabilizeandacquirebasaltone(45–60min).Then,increasingconcentrationsofET-1(10-10to3x10-7M),5-HT,orPE(10-9to10-5or10-4M)wereappliedextraluminally,andchangesinintraluminaldiametersfrombasaltoneweremeasuredonlineusingaclosed*circuitvide...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第12期