FunctionalCharacterizationofBoneMorphogeneticProteinBindingSitesandSmad1/5ActivationinHumanVascularCells
...ruitmentofalow-affinitytypeIIreceptor(Koenigetal.,1994;tenDijkeetal.,1994b;Macias-Silvaetal.,1998;Kirschetal.,2000).BMP2andBMP4areconsideredtobindtothesamereceptors,comprisingALK2,ALK3,orALK6incombinationwithBMPR-II,Act-RII,orActR-IIB(tenDijkeetal.,1994b;Macías-Silvaetal.,1998).However,theBMP...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第2期AntimonocyteChemoattractantProtein-1GeneTherapyAttenuatesGraftVasculopathy
...ctfromtheusualcoronaryatheroscleroticlesions.1,2Inanimalmodels,infiltratingmacrophagesconcentrateearlyintheinterstitiumandvessels,andpersistentcytokineandchemokineexpressionareevident.3,4Thelesionexpandswithinfiltratesfollowedbyagradualincreaseinthepresenceofsmoothmusclecells,5whichhavebeensuggested...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第10期PU.1isnotstrictlyrequiredforBcelldevelopmentanditsabsenceinducesaB-2toB-1cellswitch
...cellsnormyelomonocyticcellsandfetalliversuspensionsneithergenerateBcellsnormacrophagesinculture(1–3),althoughimmaturemyeloidcelllinescanbeestablishedinthepresenceofIL-3,IL-6,andstemcellfactor(SCF)(4).FailuretoproduceBlineagecellsinculturecanberescuedbyputativedownstreamtargetgenes:enforcedexpressi...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第10期IdentificationoftheFirstSyntheticSteroidogenicFactor1InverseAgonists:PharmacologicalModulationofSteroidogenicEnzymes
...totypeinverseagonistlead,wasusedtoshowthatSF-1constitutiveactivitycanbepharmacologicallymodulatedbyasyntheticligand.Inaphysiologicalsystemofendocrinefunction,theexpressionofseveralreportedSF-1targetgenes,includingSF-1itself,wasinhibitedbytreatmentwithAC-45594andanalogs.Thus,pharmacologicalmodulation...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期圍麻醉期支氣管痙攣、哮喘急性發作的預防及處理
...活體情況會有所不同。有報道哮喘患者氣管插管後吸入1.1MAC七氟醚10min後氣道阻力降低的程度大於1.1MAC的異氟醚和氟烷[1]。用七氟醚誘導插管,可使輕到中度哮喘患兒氣道阻力先增加,但在臨牀上無明顯不良後果;對於正常患...
醫源資料庫;在線期刊;中華現代外科學雜誌;2007年第4卷第6期氟化物影響人體健康機制的研究進展
...達均降低。說明高氟或氟中毒可使單個核細胞表面LFA-1和Mac-1表達量減少,這可能影響淋巴細胞與血管內皮細胞的粘附,從而影響免疫反應的發生。高氟使單個核細胞表面LFA-1和Mac-1表達減少,其機制可能是由於高氟抑制了淋巴細...
醫源資料庫;在線期刊;中華醫學實踐雜誌;2007年第6卷第1期炎症標誌物CRP、IL6和ICAM1與冠心病的關係
...體爲淋巴細胞功能相關抗原1(LFA1,又稱CD11a/CD18)和Mac1(又稱CD11b/CD18,Mol及CR3),均屬於整合素家族。ICAM1/LFA1,ICAM1/Mac1主要介導單核細胞、淋巴細胞及中性粒細胞與內皮細胞黏附,促進炎症細胞聚集。 可...
醫源資料庫;在線期刊;齊魯醫學雜誌;2006年第21卷第2期瑞芬太尼在臨牀麻醉的應用
...智消失,瑞芬太尼的應用必須聯合丙泊酚的滴注或吸入0.3MAC濃度的麻醉藥如異氟醚[5]。單次給藥時,瑞芬太尼使患者意識喪失的ED50爲12μg/kg,而阿芬太尼爲17μg/kg,且瑞芬太尼的鎮痛作用爲阿芬太尼的20~30倍[6]。瑞芬太尼...
醫源資料庫;在線期刊;中華醫學實踐雜誌;2006年第5卷第9期InnateimmunitymediatedbyTLR9modulatespathogenicityinananimalmodelofmultiplesclerosis
...)diseasetimepoints.Figure3AandSupplementalTable1showaplethoraofinfiltratingmacrophagesinWTandTLR9-deficientmiceduringtheearlyphaseofclinicalEAE.ThisinfluxwasaccompaniedbytheinvasionofCD3-positivelymphocytesandamyloidprecursorprotein–positive(APP-positive)axonalstructures,indicatingcomparableacutea...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第2期RoleofHistamineProducedbyBoneMarroweCDerivedVascularCellsinPathogenesisofAtherosclerosis
...dOkinakaMemorialInstituteforMedicalResearch,Minato-ku,TokyoDepartmentofPharmacology(M.T.),SchoolofMedicine,UniversityofOccupationalandEnvironmentalHealthDepartmentofBiochemistryandMolecularPathophysiology(H.U.),SchoolofMedicine,UniversityofOccupationalandEnvironmentalHealthDepartmentofKyurinOmtestLa...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第5期