Oxygen,oxidativestress,hypoxia,andheartfailure
...eartcanutilizeavarietyofmetabolicfuels,includingfattyacids,glucose,lactate,ketones,andaminoacids.Inthefedstate,fattyacidsarethepreferredfuel,accountingforupto90%ofthetotalacetyl-CoAprovidedtocardiacmitochondria(5).Fattyacidsaremetabolizedby?-oxidation,producingacetyl-CoA,NADH,andFADH2.Theacetyl-CoAe...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期Interleukin12p40isrequiredfordendriticcellmigrationandTcellprimingafterMycobacteriumtuberculosisinfection
1TrudeauInstitute,Inc.,SaranacLake,NY129832GenentechInc.,SouthSanFrancisco,CA94080Migrationofdendriticcells(DCs)tothedraininglymphnode(DLN)isrequiredfortheactivationofnaiveTcells.WeshowherethatmigrationofDCsfromthelungtotheDLNafterMycobacteriumtuberculosis(Mtb)exposureisdefectiveinmicelackinginterle...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第7期第十七章 血清酶定量的檢測技術--第一節 概述
...(E)成正比例。可以下列二式表示之: v=△P/△t=k·E 此式以單位時間(t)內產生物(P)生成量表示反應速度 v=-△S/△t=k·E 此式中以底物(S)減少量取代產物生成量。 以上二式是衡量測酶活性濃度方...
醫源資料庫;醫源圖書館;教材類;臨牀生物化學PU.1regulatesthecommitmentofadulthematopoieticprogenitorsandrestrictsgranulopoiesis
TheWalterandElizaHallInstituteofMedicalResearch,Parkville,Victoria3050,AustraliaAlthoughthetranscriptionfactorPU.1isessentialforfetallymphomyelopoiesis,weunexpectedlyfoundthateliminationofthegeneinadultmicealloweddisturbedhematopoiesis,dominatedbygranulocyteproduction.Impairedproductionoflymphocytes...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第9期GeneticVariabilityamongSerotypeG4ItalianHumanRotaviruses
...pecific)and11P(VP4-specific)types(11).StrainswithtypeG1P[8]areunanimouslyacknowledgedasthemostprevalentandubiquitoustype;strainswithtypesG2P[4],G3P[8],andG4P[8]areubiquitous,buttheirdiffusionistemporalandregional(14).Since1996thecirculationofstrainswithG9P[8]orG9P[6]typehasbeenwidelyreported,whileot...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第3期Ofmiceandmen:theironage
...1.Mousemodelsofthisdiseasehavenowbeendevelopedby2groups,Huangetal.andNiederkofleretal.,throughtargeteddisruptionoftheHjvgene(seetherelatedarticlesbeginningonpages2180and2187).ThesemutantmicewillallowfurtherinvestigationintotheroleofHJVintheregulationofironhomeostasis,arolethattodateremainselusive.Se...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第8期PGC-1coactivators:inducibleregulatorsofenergymetabolisminhealthanddisease
...siologicandnutritionalcuestocriticalgeneregulatoryresponses.Themolecularlinksbetweenexternalstimuli,cellularsignalingevents,andNR-mediatedtranscriptionalcontrolarecurrentlybeingunraveled.NewinformationemergingoverthepastdecadehasdemonstratedthatNRsreceiveregulatoryinputthroughmultiplemechanismsinclu...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期ActivationofDendriticCellsthroughtheInterleukin1Receptor1IsCriticalfortheInductionofAutoimmuneMyocarditis
...edicineA,UniversityHospital,CH-4031Basel,Switzerland2UniversityHealthNetwork,DepartmentsofMedicalBiophysicsandImmunology,UniversityofToronto,Toronto,OntarioM5S1A8,Canada3DepartmentofPathology,UniversityHospital,CH-8091Zurich,Switzerland4IMBA,InstituteforMolecularBiotechnologyoftheAustrianAcademyofSc...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第3期ActivationofDendriticCellsthroughtheInterleukin1Receptor1IsCriticalfortheInductionofAutoimmuneMyocarditis
...edicineA,UniversityHospital,CH-4031Basel,Switzerland2UniversityHealthNetwork,DepartmentsofMedicalBiophysicsandImmunology,UniversityofToronto,Toronto,OntarioM5S1A8,Canada3DepartmentofPathology,UniversityHospital,CH-8091Zurich,Switzerland4IMBA,InstituteforMolecularBiotechnologyoftheAustrianAcademyofSc...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第3期PPARandhumanmetabolicdisease
...linicalBiochemistryand2DepartmentofMedicine,UniversityofCambridge,Addenbrooke’sHospital,Cambridge,UnitedKingdom.AbstractThenuclearreceptorfamilyofPPARswasnamedfortheabilityoftheoriginalmembertoinducehepaticperoxisomeproliferationinmiceinresponsetoxenobioticstimuli.However,studiesontheactionandstru...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期