MolecularEpidemiologyofClinicalCryptococcusneoformansStrainsfromIndia
...diaInstituteforMolecularBioscienceandARCCentreinBioinformatics,UniversityofQueensland,Queensland,AustraliaABSTRACTLittleisknownaboutthemolecularepidemiologyofthehumanpathogenicfungusCryptococcusneoformansinIndia,acountrynowinthemidstofanepidemicofAIDS-relatedcryptococcosis.Westudied57clinicalisolate...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第11期Postnatalacquisitionofendotoxintoleranceinintestinalepithelialcells
...talintestinalmacrophages,incontrast,wereconstitutivelynonresponsivetoLPS.AcquisitionofLPSresistancewasparalleledbyaspontaneousactivationofIECsshortlyafterbirthasillustratedbyphosphorylationofIB-andnucleartranslocationofNF-Bp65insituaswellastranscriptionalactivationofMIP-2.Importantly,thespontaneousI...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期RegulationofosteoclastfunctionandbonemassbyRAGE
...resentevidenceforaroleofRAGEinosteoclastmaturationandfunction,whichhasconsequencesforboneremodeling.MicelackingRAGEhadincreasedbonemassandbonemineraldensityanddecreasedboneresorptiveactivityinvivo.Invitro–differentiatedRAGE-deficientosteoclastsexhibiteddisruptedactinringandsealingzonestructures,im...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期Pathogenicroleforskinmacrophagesinamousemodelofkeratinocyte-inducedpsoriasis-likeskininflammation
...proliferative,inflammatoryskindiseaseinK14-Cre-IKK2fl/flmicewasadirectconsequenceofthepresenceofmacrophagesintheskin,astargeteddeletionofCD18,whichpreventedaccumulationofgranulocytesbutnotmacrophages,didnotleadtomajorchangesinthephenotype.TargeteddeletionofthereceptorforIFN-revealedthatthepathogenes...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第8期FibroblastGrowthFactorReceptor-1ExpressionIsRequiredforHematopoieticbutnotEndothelialCellDevelopment
...ialgrowthfactor(VEGF).ExpressionofFGFR-1inendothelialcellprecursorswasnotrequiredforvasculardevelopment,andvascularizationwasenhancedinFGFR-1–deficientembryoidbodiescomparedwithwild-typestemcells.Incontrast,hematopoieticdevelopmentwasseverelydisturbed,withreducedexpressionofmarkersforprimitiveandd...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第5期SuppressionandRegressionofChoroidalNeovascularizationbySystemicAdministrationofan51IntegrinAntagonist
...inedwithDAPI(KirkegaardandPerryLaboratories,Gaithersburg,MD)andmountedwithAquamount(BritishDrugHouse,Poole,Dorset,UK).SerialsectionswerestainedwithbiotinylatedGriffoniasimplicifolialectinB4(GSA;VectorLaboratories)toidentifychoroidalneovascularizationasdescribedpreviously(Ozakietal.,1998).Inbrief,sli...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期CorrelationbetweenImmunologicResponsestoaRecombinantGlycoprotein120VaccineandIncidenceofHIV-1InfectioninaPhase3HIV-1PreventiveVaccineTri
...aceborecipients,n=1805),bindingandneutralizingantibodyresponsestorgp120werequantitated.Acase-cohortdesignwasusedtostudycorrelationsbetweenantibodylevelsandHIV-1incidence.Results.PeakantibodylevelsweresignificantlyinverselycorrelatedwithHIV-1incidence.Therelativerisk(RR)ofinfectionwas0.63(95%confiden...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第5期InhibitoryGatingModulationofSmallConductanceCa2+-ActivatedK+ChannelsbytheSyntheticCompound(R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtyla
...orreview,seeBlanketal.,2004).Thepotentscorpiontoxinsscyllatoxin(fromLeiurusquinquestriatus;Chicchietal.,1988)andtherecentlydescribedtamapin(fromMesobuthustamulus;Pedarzanietal.,2002),bothdisplaceapaminfromitsbindingsiteandexhibitblockerselectivitysimilartoapamin.Basedonscyllatoxin,anartificialpeptid...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第11期MechanismsUnderlyingCampylobacterfetusPathogenesisinHumans:Surface-LayerProteinVariationinRelapsingInfections
...ogie,HpitalSt-LucduCentreHospitalierdel‘UniversitédeMontréal,Montréal,Québec,CanadaCampylobacterfetuscausesgastrointestinalandsystemicinfectionsinhumans.Althoughrelapseiscommondespiteantibiotictreatment,themechanismsarenotwellunderstood.Thesurface-layerproteins(SLPs)ofC.fetus,whicharecriticali...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第12期UptakeofLeishmaniamajorbydendriticcellsismediatedbyFcreceptorsandfacilitatesacquisitionofprotectiveimmunity
...,Tcells,andnoIL-12production.Herein,wedemonstratethatuptakeofL.majorbyDCsrequiredparasite-reactiveimmunoglobulin(Ig)GandinvolvedFcRIandFcRIII.Invivo,DCinfiltrationofL.major–infectedskinlesionscoincidedwiththeappearanceofantibodiesinsera.SkinofinfectedBcell–deficientmiceandFc–/–micecontainedf...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第1期