Anti-MCP-1GeneTherapyInhibitsVascularSmoothMuscleCellsProliferationandAttenuatesVeinGraftThickeningBothInVitroandInVivo
【摘要】Objective-Becauselateveingraftfailureiscausedbyintimalhyperplasia(IH)andacceleratedatherosclerosis,andtheseprocessesarethoughttobeinflammationdriven,influxofmonocytesisoneofthefirstphenomenaseeninIH,wewouldliketoprovidedirectevidenceforaroleoftheMCP-1pathwayinthedevelopmentofveingraftdis...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第9期Riskfactorsforlowserum25-hydroxyvitaminDconcentrationsinotherwisehealthychildrenandadolescents
FrancisLWeng,JustineShults,MaryBLeonard,VirginiaAStallingsandBabetteSZemel1FromtheDepartmentofMedicine,UniversityofPennsylvaniaSchoolofMedicine,Philadelphia,PA(FLW);theDepartmentofBiostatisticsandEpidemiology,CenterforClinicalEpidemiologyandBiostatistics,UniversityofPennsylvaniaSchoolofMedicine,Phil...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年86卷第1期遊離PSA、總PSA在前列腺增生與前列腺癌診斷中的應用評價
...,血清PSA也可升高,尤其處於診斷灰區(總PSA在4.0~10.0ng/mg範圍內)診斷特異性降低。前列腺穿刺活檢雖然可靠,因其具有創傷性,患者較難接受。爲了提高對PCA診斷的準確性,Christenssont等[1]首先提出了遊離PSA(f-PSA)與總PS...
醫源資料庫;在線期刊;中華實用醫藥雜誌;2008年第8卷第9期Platelet-DerivedGrowthFactor-ßReceptorActivationIsEssentialforFibroblastandPericyteRecruitmentduringCutaneousWoundHealing
【摘要】Connectivetissueremodelingprovidesmammalswitharapidmechanismtorepairwoundsafterinjury.Inappropriateactivationofthisreparativeprocessleadstoscarringandfibrosis.Here,westudiedtheeffectsofplatelet-derivedgrowthfactorreceptor-ßblockadeinvivousingtheplatelet-derivedgrowthfactorreceptor(...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第12期ExternalQualityAssessmentforDetectionofChlamydiatrachomatis
UnitedKingdomNationalExternalQualityAssessmentSchemeforMicrobiology,QualityAssuranceLaboratory,HealthProtectionAgencyCentreforInfections,London,UnitedKingdomABSTRACTTheuseofmolecularmethodsfordetectionofChlamydiatrachomatisisincreasinginclinicallaboratories.Externalqualityassessmentenablesunbiasedmo...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第3期CD40/CD154ligationinducesmononuclearcelladhesiontohumanrenalproximaltubulecellsviaincreasedICAM-1expression
...aywasexploredinprimaryculturesofhumanrenalproximaltubuleepithelialcells.UsingacDNAgenearrayspecificforhumanNF-Bsignalpathwaygenes,38geneswereupregulatedat1h,and7ofthesegenesremainedupregulatedat3h.Ofthesegenes,intercellularadhesionmolecule-1(ICAM-1)wasexploredinfurtherdetail.Quantitativereal-timePCR...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第7期MatrixMetalloproteinase-ProducedbyHumanCXCL-StimulatedNaturalKillerCells
...colocalizedwith2ß1integrinonCXCL-12-stimulatedNK-cellsurface.Thebindingofpro-MMP-1with2ß1integrinrequiredactivationofGi-coupledpathway.However,theproductionofMMP-1fromCXCL12-stimulatedNKcellswasmediatedbyp38andmitogen-activatedorextracellularsignal-regulationproteinkinasekinase1/2inamann...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第8期ApolipoproteinEInterruptsInterleukin-1ßSignalinginVascularSmoothMuscleCells
...anismsremainunclear.WehereinvestigatedtheeffectofapoEonintracellularsignalingbyinterleukin-1ß(IL-1ß),aproinflammatorycytokinepresentinatheroscleroticlesions.MethodsandResults-IL-1ß-inducedexpressionandactivationofinduciblenitricoxidesynthaseandcyclooxygenase-2wereinhibitedbyapoEinv...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第7期烏司他丁在心肺復甦期間臨牀價值
...】心肺復甦;烏司他丁;保護作用TheclinicalvalueofUlinastainduringcardiopulmonaryresuscitationHUANGYuan-xu,XIEGui-an,WANGRui-jin,etal.DepartmentofEmergency,theFirstPeople’sHospitalofHuaihua,Huaihua418000,China[Abstract]ObjcctiveToinvestigatetheincidenceofsystemicinflammatoryresp...
醫源資料庫;在線期刊;中華現代內科學雜誌;2009年第6卷第3期Leptin對小鼠窗口期子宮內膜上皮細胞MMP-9及ICAM-1的影響*
...ellularadhesionmolecule-1(ICAM-1)secretedfromendometrialepithelialcellsduringembryoimplantationwidowstageinmice.MethodsEndometrialepithelialcellsfrommiceintheembryoimplantationstagewerefertilizedinvitro.TheendometrialepithelialcellsweretreatedwithLeptin.Theimmunohistochemicalmethodwasappliedtotestth...
醫源資料庫;在線期刊;中華現代婦產科學雜誌;2011年第8卷第1期