ComparisonofThreeMolecularMethodsUsedforSubtypingofLegionellapneumophilaStrainsIsolatedduringanEpidemicofLegionellosisinRome
...omunrelatedstrains.PFGEwasperformedasdescribedbyCastellaniPastorisetal.(5)byusing20UofNotI(Roche,Italy)forovernightmacrorestrictionat37°CofthegenomicDNAplugs.SaccharomycescerevisiaechromosomalDNA(Bio-Rad,Hercules,Calif.)wasusedasasizemarker.AsshowninFig.1,PFGEproducedgenomicpatternsthatwerethesamef...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期北醫爲邊疆留下一支不走的醫療隊
...家接壤無自然屏障,自古以來,思茅人民與周邊3個國家一直存在通婚、互市。那裏的熱帶、亞熱帶叢林是熱帶病高發地區,人員交往頻繁使得傳染病非常容易發生,思茅也因此成爲有名的“瘴癘之區”。在舊中國,鼠疫、天花...
醫學教育;校園動態;北京大學醫學部ImmuneresponsesandHIV:alittleorderfromthechaos
...(7).Andforeachepitopethepatternofescapemutationsislimitedbutrarelycompletelyuniform(8).StochasticityinthetimingandpatternofCTLescapemaybepoweringadestabilizing“variabilityengine.“Onceimmuneescapemutantsbegintoaccrue,theantigeniccompositionoftheviruschanges,fundamentallyalteringtheimmuneresponse....
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第3期Blimp-1isrequiredformaintenanceoflong-livedplasmacellsinthebonemarrow
...noglobulin-secretingcells.Cell.77:297–306.Shaffer,A.L.,K.I.Lin,T.C.Kuo,X.Yu,E.M.Hurt,A.Rosenwald,J.M.Giltnane,L.Yang,H.Zhao,K.Calame,andL.M.Staudt.2002.Blimp-1orchestratesplasmacelldifferentiationbyextinguishingthematureBcellgeneexpressionprogram.Immunity.17:51–62.Lin,Y.,K.Wong,andK.Calame.1997....
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第11期HeterogeneityofBiofilmsFormedbyNonmucoidPseudomonasaeruginosaIsolatesfromPatientswithCysticFibrosis
...creasedourunderstandingofthecomplexarchitecturesofbacterialbiofilms(6,49).Byusingtheflowchambersetup,wild-typeP.aeruginosaPAO1biofilmsshowdifferentiatedmushroomstructureswithwater-filledchannels.BiofilmformationinP.aeruginosaishypothesizedtobeaprocessofdevelopmentthatincludesinitialattachment,thefor...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期IFN-dependent,spontaneousdevelopmentofcolorectalcarcinomasinSOCS1-deficientmice
1DivisionofMolecularandCellularImmunology,MedicalInstituteofBioregulation,KyushuUniversity,Fukuoka812-8582,Japan2DepartmentofOncologicalScience(Urology),OitaUniversity,Oita879-5593,Japan3DepartmentofPathology,KurumeUniversity,Kurume830-0011,JapanApproximately20%ofhumancancersareestimatedtodevelopfro...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第6期ImmunofluorescenceAssayforDetectionoftheNucleocapsidAntigenoftheSevereAcuteRespiratorySyndrome(SARS)-AssociatedCoronavirusinCellsDerivedfro
...eswereobservedunderafluorescencemicroscope.NACisamucolyticagentandiscommonlyusedintreatingmucins,whicharelargeglycoproteinsinthemucusandareknowntobeassociatedwithcellsderivedfromtherespiratorytract(20).ToexaminetheeffectofNACtreatment,aliquotsofuntreatedmucuscellpelletsfromsomethroatwashsampleswerep...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第5期NosocomialOutbreakofPediatricGastroenteritisCausedbyCTX-M-14-TypeExtended-Spectrum-Lactamase-ProducingStrainsofSalmonellaentericaSerovarLondon
...fectiousdiarrhea.Clin.Infect.Dis.32:331-351.Kim,H.H.,M.S.Park,Y.H.Kang,J.Y.Yu,S.H.Kim,Y.H.Shin,M.J.Kim,andB.K.Lee.1999.EpidemiologicalcharacteristicsofSalmonellastrainsisolatedrecentlyinKorea.J.KoreanSoc.Microbiol.34:595-598.Kim,S.,Y.H.Kang,H.J.Nam,O.Y.Lim,W.S.Seok,J.K.Park,andB.K.Lee.2003.Avirulent...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期最新國內最具影響力的學術論文(生物類)
...作者:Zhang,LX;Wang,F;Wang,L;Wang,WK;Liu,BC;Liu,J;Chen,MH;He,Q;Liao,YH;Yu,XQ;Chen,N;Zhang,JE所屬機構:北京大學第一醫院來源期刊:LANCET,2012,379(9818):815-822被引次數:29北大醫院腎臟內科王海燕教授研究組對中國慢性腎臟病流行病進行了統計以及調...
醫藥經濟;生物技術;技術要聞TwistmediatessuppressionofinflammationbytypeIIFNsandAxl
...ndimmunomodulatoryproperties.TheimmunosuppressiveactionsoftypeIIFNsarepoorlyunderstood,butIFN-mediatedsuppressionofTNFproductionhasbeenimplicatedintheregulationofinflammationandcontributestotheeffectivenessoftypeIIFNsinthetreatmentofcertainautoimmuneandinflammatorydiseases.Inthisstudy,weinvestigated...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第8期