鋅原卟啉對博萊黴素致大鼠肺纖維化模型的影響*
【摘要】目的觀察血紅素加氧酶-1(HO-1)抑制劑鋅原卟啉(Znpp)對博萊黴素(BLM)致大鼠肺纖維化模型病理和病理生理改變的影響,探討Znpp在BLM誘導肺纖維化發病中的作用。方法健康SD大鼠60只隨機分三組:生理鹽水(NS)組、B...
醫源資料庫;在線期刊;中華現代內科學雜誌;2007年第4卷第11期RenalHemodynamicInflammatoryandApoptoticResponsestoLipopolysaccharideinHO-C/CMice
...】Lipopolysaccharide(LPS)inducesthestress-responsivegenehemeoxygenase-1(HO-1).ThepresentstudyexaminedthesignificanceofHO-1inresponsetoLPS.InHO-1C/Cmice,ascomparedwithHO-1+/+mice,LPSprovokedagreaterreductioninglomerularfiltrationrateandrenalbloodflow,increasedrenalcytokineexpression,andincreasedacti...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第6期InvolvementofHypoxia-InducibleTranscriptionFactorsinPolycysticKidneyDisease
...poietin(EPO)productionandinterstitialvascularizationareincreasedcomparedwithotherkidneydiseases.EPOandseveralangiogenicfactorsarecontrolledbyhypoxia-inducibletranscriptionfactors(HIFs),whicharecomposedofaconstitutiveß-subunitandtwoalternative-subunits(HIF-1,HIF-2).Wehypothesizedthatcystexpansi...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第3期冠心病患者血清TBIL與OX-LDL水平的變化及其相關性
...YIWei-lian,YUANHan-rao,CHENLing,etal(laboratoryDepartmentofAffiliatedHospitalofGuangdongMedicalCollege,Zhanjiang524001,Guangdong,PRChina)Abstract:ObjectiveToinvestigatethechangesoftotalbiliruin(TBIL)andoxidizedlowdensitylipoprotein(OX-LDL)andtherelationshipinpatientswithcoronaryheartdi...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2005年第5卷第2期ExpressionofHemeOxygenase-1inHumanVascularCellsIsRegulatedbyPeroxisomeProliferator-ActivatedReceptors
...investigateifthevasculoprotectiveandanti-inflammatoryenzymehemeoxygenase-1(HO-1)isregulatedbyPPARligandsinvascularcells.MethodsandResults—WeshowthattreatmentofhumanvascularendothelialandsmoothmusclecellswithPPARligandsleadstoexpressionofHO-1.AnalysisofthehumanHO-1promoterintransienttransfectio...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第6期ProbingtheExistenceofGProtein-CoupledReceptorDimersbyPositiveandNegativeLigand-DependentCooperativeBinding
...ivecooperativebinding.Becausepositivecooperativebindingcannotbeexplainedwithoutconsideringreceptorasmultivalent,thesebindingdatasupporttheconceptofGPCRdimerizationprocess.Theresults,whichareingoodaccordancewiththepredictionsofpreviousmathematicalmodels,suggestthatbindingexperimentscanbeusedtoprobeth...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第11期急性腦梗死與血清膽紅素水平關係的探討
...下,Bil升高伴有細胞微粒體血紅素氧合酶(hemeoxygenase,HO)活性升高,而HO具有抗AS功能[13]。HO的誘導型是HO-1,其主要通過降解具有促氧化作用的遊離血紅素並生成CO和Bil起作用[14]。目前認爲[5],HO-1抗腦缺血損傷的可能...
醫源資料庫;在線期刊;中華現代內科學雜誌;2008年第5卷第7期Nrf2GeneTransferInducesAntioxidantEnzymesandSuppressesSmoothMuscleCellGrowthInVitroandReducesOxidativeStressinRabbitAortaInVivo
...ground-Reactiveoxygenspecies(ROS)playamajorroleinvascularinflammationandpathophysiologyofmanyvasculardiseasessuchasatherosclerosisandinjury-inducedneointimaformationafterballoonangioplasty.NuclearfactorE2-relatedfactor-2(Nrf2)isatranscriptionfactororchestratingantioxidantandcytoprotectiveresponseson...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第4期Protectionoftransplant-inducedrenalischemia-reperfusioninjurywithcarbonmonoxide
...tkidneygraft,preservedinUniversityofWisconsinsolutionat4°Cfor24h,wasorthotopicallytransplantedintosyngeneicrats.RecipientsweremaintainedinroomairorexposedtoCO(250ppm)inairfor1hbeforeand24haftertransplantation.Animalswerekilled1,3,6,and24haftertransplantationtoassessefficacyofinhaledCO.Rapidupreg...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第11期Hemeoxygenase-1isamodulatorofinflammationandvaso-occlusionintransgenicsicklemice
...ofMinnesota,Minneapolis,Minnesota,USA.2DepartmentofSurgery,HarvardMedicalSchool,BethIsraelDeaconessMedicalCenter,Boston,Massachusetts,USA.AbstractTransgenicsicklemiceexpressing?ShemoglobinhaveactivatedvascularendotheliumthatexhibitsenhancedexpressionofNF-Bandadhesionmoleculesthatpromotevascularstasi...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期