CD4–CD8–Tcellscontrolintracellularbacterialinfectionsbothinvitroandinvivo
...teintolong-livedmemorycells.WeshowthatararepopulationofCD4–CD8–CD3++–NK1.1–Tcellshassimilarfunctions.ThesecellspotentlyandspecificallyinhibitthegrowthoftheintracellularbacteriaMycobacteriumtuberculosis(M.tb.)orFrancisellatularensisLiveVaccineStrain(LVS)inmacrophagesinvitro,promotesurvivalofm...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第2期Expansionandlong-rangedifferentiationoftheNKTcelllineageinmiceexpressingCD1dexclusivelyoncorticalthymocytes
...Unlikeconventionalmajorhistocompatibilitycomplex–restrictedTcells,V14-J18NKTcelllineageprecursorsengageincognateinteractionswithCD1d-expressingbonemarrow–derivedcellsthatarebothnecessaryandsufficientfortheirthymicselectionanddifferentiation,butthenatureandsequenceoftheseinteractionsremainpartial...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第2期RegulationofnaturalcytotoxicitybytheadaptorSAPandtheSrc-relatedkinaseFyn
...tréal,Montréal,QuébecH3G146,CanadaSAPisanadaptorproteinthatisexpressedinNKandTcells.ItismutatedinhumanswhohaveX-linkedlymphoproliferative(XLP)disease.ByinteractingwithSLAMfamilyreceptors,SAPenablestyrosinephosphorylationsignalingofthesereceptorsbyitsabilitytorecruittheSrc-relatedkinase,Fyn.Here,w...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第1期Alteredexpressionprofileoftransportersintheinnermedullarycollectingductofaquaporin-1knockoutmice
...rtmentofNephrology,GraduateSchool,TokyoMedicalandDentalUniversity,YushimaBunkyo-Ku,Tokyo,JapanDepartmentofPhysiologyUniversityofArizona,Tuscon,ArizonaABSTRACTAquaporin-1isthemajorproteinresponsiblefortransportofwateracrosstheepitheliaoftheproximaltubuleandthindescendinglimbs.Rapidwatereffluxacrossth...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第7期Neurokinin1ReceptorsTriggerOverlappingStimulationandInhibitionofCaV2.3(R-Type)CalciumChannels
【關鍵詞】Neurokinin1Neurokinin(NK)1receptorsandCaV2.3calciumchannelsarebothexpressedinnociceptiveneurons,andmicelackingeitherproteindisplayalteredresponsestonoxiousstimuli.Here,weexaminedmodulationofCaV2.3throughNK1receptorsexpressedinhumanembryonickidney293cells.WefindthatNK1receptorsgenerate...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第1期孕早期人母-胎免疫耐受機制的研究
...統對滋養細胞抗原免疫應答狀態。結果:蛻膜組織中CD56+NK細胞含量高於孕婦及對照組外周血CD56+細胞比例(P<0.05);蛻膜組織中NK細胞殺傷活性明顯低於孕婦及對照組外周血NK細胞殺傷活性(P<0.05);滋養細胞抑制母方淋巴細胞增殖...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學PNAS:能抗癌的戰鬥雞
...形多肽與脂質膜之間的靜電作用能力,這是使NK-lysin多肽能夠殺死細菌和癌細胞的一個重要因素。研究人員認爲這項發現爲疾病研究打開了新窗口,能夠引導抗癌研究,或者幫助研發抵禦感染甚至治療疾病的新藥物。Womack稱他們...
行業資訊;臨牀快報;腫瘤相關SubstanceP,NeurokininsAandB,andSyntheticTachykininPeptidesProtectMesencephalicDopaminergicNeuronsinCultureviaanActivity-DependentMechanism
...electivelyastheymature.Thethreenativetachykinins,substanceP(SP),neurokinin(NK)A,andNKBaffordedsubstantialprotectionagainstDAcelldemise.TheselectiveNK1receptorantagonist[D-Pro9,[spiro--lactam]Leu10,Trp11]substanceP(GR71251)wassufficientinitselftosuppresstheeffectofSP,whereasacotreatmentwithGR71251and...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第5期Eliminationofratspinalneuronsexpressingneurokinin1receptorsreducesbladderoveractivityandspinalc-fosexpressioninducedbybladderirritation
...umoto-city,Nagano,JapanABSTRACTSubstanceP(SP)bindingtoneurokinin1receptors(NK1R)inthespinalcordreportedlyplaysanimportantroleinthemicturitionreflexaswellasinnociceptiveresponses.WethereforeinvestigatedtheeffectofablationofNK1R-expressingneuronsinthespinalcordusingsaporin,aribosome-inactivatingprotei...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第3期DNAMethylationMaintainsAllele-specificKIRGeneExpressioninHumanNaturalKillerCells
...self–majorhistocompatibilitycomplexclassImolecules,allowingnaturalkiller(NK)cellstorecognizeaberrantcellsthathavedown-regulatedclassI.NKcellsexpressvariablenumbersandcombinationsofhighlyhomologousclonallyrestrictedKIRgenes,butuniformlyexpressKIR2DL4.WeshowthatNKclonesexpressboth2DL4allelesandeithe...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第2期