Nod1actsasanintracellularreceptortostimulatechemokineproductionandneutrophilrecruitmentinvivo

...nse.Abbreviationsused:AcAiQ,D-Ala-Gln-octadecylester;AcMTP,MurNAc-L-Ala--D-Glu-L-Lys(stearoyl)-OH;DAP,diaminopimelicacid;GlcNAc,N-acetyl-glucosamyl;HEK,humanembryonickidney;iE-DAP,-D-glutamyl-meso-DAP;iQ-DAP,-D-glutaminyl-meso-DAP;MurNAc,N-acetyl-muramyl;PGN,peptidoglycan;TLR,Toll-likereceptor.J.Mas...

6-1蛋白質分選的基本原理

...+H3N-Met-Met-Ser-Phe-Val-Ser-Leu-Leu-Leu-Val-Gly-Ile-Leu-Phe-Trp-Ala-Thr-Glu-Ala-Glu-Gln-Leu-Thr-Lys-Cys-Glu-Val-Phe-Gln-返回內質網-Lys-Asp-Glu-Leu-COO-（KDEL）由質膜到內體Tyr-X-X-Φ　　每一種信號序列決定特殊的蛋白質轉運方向，如輸入內質網的蛋白質通常N...

DistributionofNocardiaSpeciesinClinicalSamplesandTheirRoutineRapidIdentificationintheLaboratory

...ofthemostcommonspeciesisolatedduringthissurvey.Pyrrolidonylaminopeptidase,-glutamylaminopeptidase,-mannosidase,and-glucosidasewerefoundtobehighlydiscriminatingandcouldbeusedtodevelopanidentificationscheme.INTRODUCTIONNocardiaspeciesareisolatedwithanincreasedfrequencyfromclinicalspecimens,especiallyi...

高血糖伴高血脂大鼠動物血液流變學的變化

...;Highfatdietgroup（H）;Diabetescompliˉcatedbyhighfatdietgroup（HD）.Glucose（Glu），totalcholesterol（TC）andtriglycerides（TG）intheplasmaweremeasuredatweek0，1，2，4，8and13.Thehemorheologicalchangesofdiabetesratscomplicatedbyhyperlipidemiawerestudied.ResultsInweek1，2，4，8and1...

Bacicitinib治療後的症狀與體徵較甲氨蝶呤顯著改善

...nib的單藥和聯合治療方案在幫助患者取得臨牀緩解上優於甲氨蝶呤單藥治療方案。這些成果在舊金山舉行的美國風溼病學會/風溼病衛生專業人員協會年度會議上進行了公佈，證明在研藥物Baricitinib在改善類風溼關節炎症狀和體徵...

米非司酮配伍甲氨蝶呤保守治療異位妊娠療效分析

【摘要】目的探討米非司酮配伍甲氨蝶呤保守治療異位妊娠的療效。方法將108例患者隨機分爲口服米非司酮（Ru486)治療組（A組），肌注甲氨蝶呤治療組（B組）及米非司酮和甲氨蝶呤聯合治療組（C組）進行對比分析。三組在年齡...

風溼聖藥膠囊治療類風溼性關節炎的臨牀研究

...組，治療組(n=42)採用風溼聖藥膠囊治療，對照組(n=30)採用甲氨蝶呤(MTX)治療，兩組療程均爲8周。觀察治療前、後兩組臨牀療效、晨僵時間、關節壓痛指數、關節腫脹指數、血沉(ESR)、C反應蛋白(CRP)。結果兩組治療後治療組88.1%，...

TheAmine-ContainingCutaneousIrritantHeptylamineInhibitstheVolume-RegulatedAnionChannelandMobilizesIntracellularCalciuminNormalHumanEpidermal

...areproinflammatorymediators.Thesemetabolitesincludeaminoacids(e.g.,glycine,glutamate,andaspartate),polyols,lactate,bicarbonate,andATP(GrygorczykandGuyot,2001;Hisadomeetal.,2002;Darbyetal.,2003;NiliusandDroogmans,2003;Ullrichetal.,2006).VRACsalsoparticipateintheregulationoffundamentalcellfunctions,pa...

Mitochondrialaldehydedehydrogenase-2(ALDH2)Glu504Lyspolymorphismcontributestothevariationinefficacyofsublingualnitroglycerin

...ntstudy,weshowthatthecommonG-to-Apolymorphisminexon12ofALDH2—resultinginaGlu504LysreplacementthatvirtuallyeliminatesALDH2activityinbothheterozygotesandhomozygotes—isassociatedwithalackofefficacyofsublingualGTNinChinesesubjects.Wealsoshowthatthecatalyticefficiency(Vmax/Km)ofGTNmetabolismoftheGlu5...

異丙酚對缺血再灌注損傷的保護作用研究進展

...神經元釋放大量的興奮性氨基酸（EAA），尤其是穀氨酸（Glu）對神經元的損傷起關鍵作用。Glu是脊椎動物中樞神經系統內主要的興奮性遞質，適量的Glu對於維持細胞的正常生理活動是必需的，但胞外Glu濃度過高則會產生毒性，導...