介入化療聯合放射治療Ⅲa期非小細胞肺癌
...者隨機分成A、B兩組,A組先行2次支氣管動脈灌注化療(BAI),第二次BAI兩週後再行直線加速器放射治療(RT);B組單純行2次BAI(對照組)。結果臨牀療效,A組(BAI+RT)和B組(BAI)分別爲89.47%和60.53%(P0.01);1、3年生存率,A、B組...
合作平臺;在線期刊;中華醫學研究雜誌;2005年第5卷第4期;論著FibrinolyticGenePolymorphismandIschemicStroke
...plasminogenactivator(tPA)–7351CTandtheplasminogenactivatorinhibitortype1(PAI-1)-6754G5Gpolymorphismsinfluencetranscriptionalactivity.Bothvariantshavebeenassociatedwithmyocardialinfarction,withincreasedriskfortheTand4Gallele,respectively.Inthisstudyweinvestigatedthepossibleassociationbetweenthesepo...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第10期中晚期原發性肺癌經支氣管動脈、胸廓內動脈灌注化療的療效觀察
【摘要】目的研究支氣管動脈灌注化療(BAI)結合胸廓內動脈灌注化療(IAI)治療中晚期原發性肺癌的可行性及臨牀價值。方法治療組30例Ⅲ、Ⅳ期原發性肺癌,行BAI+IAI;對照組28例Ⅲ、Ⅳ期原發性肺癌,行BAI。通過對CT、生活...
醫源資料庫;在線期刊;中華現代影像學雜誌;2006年第3卷第3期AntiproliferativeAgentsAlterVascularPlasminogenActivatorInhibitor-1Expression
...elialcellstreatedwithrapamycinorpaclitaxel.Plasminogenactivatorinhibitor-1(PAI-1)wasthemostconsistentlyinducedtranscriptinrapamycin-treatedhumancoronaryarteryendothelialcells.RT-PCRandELISAwereperformedtoconfirmpositivefindings.Transgenicmiceengineeredtoexpressenhancedgreenfluorescentproteinundercon...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第2期AdiponectinMediatestheSuppressiveEffectofRosiglitazoneonPlasminogenActivatorInhibitor-1Production
...levelsofadiponectinandtheprothromboticfactor,plasminogenactivatorinhibitor(PAI)-1,intype2diabeticpatients,andtoinvestigate,inanimalmodels,whethertheantithromboticactionofrosiglitazonewasmediatedthroughadiponectin.MethodsandResults—Ourclinicalstudy(n=64)showedthatafter24-weekadd-ontherapy,thero...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第12期InvolvementofTissuePlasminogenActivator-PlasminSysteminDepolarization-EvokedDopamineReleaseintheNucleusAccumbensofMice
...icalDAneurotransmission,whereasnegativeandcognitivesymptomsmayberelatedtoimpairedmesocorticalDAfunction(Seemanetal.,1976;Abi-DarghamandMoore,2003).Parkinson‘sdiseaseisaneurodegenerativedisorderinwhichthemostpredominantpathologicalfeatureistheprogressivelossofmesencephalicDAergicneurons(Goldbergeta...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第11期Rho/Rho-KinasePathwayContributestoC-ReactiveProtein–InducedPlasminogenActivatorInhibitor-1ExpressioninEndothelialCells
...ementofRho/Rho-kinasesignalinginCRP-inducedplasminogenactivatorinhibitor-1(PAI-1)expressioninbovineaorticendothelialcells(BAECs).MethodsandResults—PAI-1expressionwasdeterminedbyWesternblotting.RhoAactivationwasdeterminedbyanaffinitypull-downassayusingRho-bindingfragmentofrhotekin.NF-Bactivitywasde...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第10期AugmentationofProliferationofVascularSmoothMuscleCellsbyPlasminogenActivatorInhibitorType
...shownpreviouslythatincreasedexpressionofplasminogenactivatorinhibitortype1(PAI-1)limitsVSMCapoptosis.Becauseapoptosisandproliferationappeartobelinked,wesoughttodeterminewhetherincreasedPAI-1wouldaffectVSMCproliferation.MethodsandResults-VSMCswereexplantedfromcontrolandtransgenicmice(SM22-PAI+)inwhic...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第8期GlycatedalbuminactivatesPAI-1transcriptionthroughSmadDNAbindingsitesinmesangialcells
...andSmad-bindingCAGAsequencesarepresentintheplasminogenactivatorinhibitor-1(PAI-1)promoter.ThisstudyexaminedwhetherglycatedalbumininducesPAI-1transcriptioninhumanmesangialcells(HMC)throughSmad-bindingsitesinthePAI-1promoter.QuiescentHMCwereexposedto200µg/mlbovineserumalbumin(BSA)orglycatedBSA(G...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第10期人纖溶酶原激活物抑制物1轉基因小鼠的建立
摘 要:目的建立人纖溶酶原激活物抑制物1(PAI-1)轉基因小鼠。方法利用構建的高效真核表達載體pCAGGS—PAI-1,製備注射用DNA。以顯微注射法將目的DNA注入小鼠受精卵,再將受精卵移植到受體母鼠,製備轉基因小鼠。經鼠尾組織DN...
合作平臺;醫學論文;內科學論文;腎臟病學