TheFabFragmentofaNovelAnti-GPVIMonoclonalAntibody,OM4,ReducesInVivoThrombosisWithoutBleedingRiskinRats
【摘要】Background-InhibitionofGPVIhasbeenproposedasausefulantithromboticstrategy;however,invivoproof-of-conceptanimalstudiestargetingGPVIarelacking.Weevaluatedanovelanti-humanGPVImonoclonalantibodyOM4Fabinrats.MethodsandResults-OM4Fabspecificallyinhibitedcollagen-inducedaggregationofratplatelet...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第5期Two-PhaseAntithromboticProtectionAfterAnti-GlycoproteinVITreatmentinMice
...lplateletagonists,actingthroughdifferentreceptors,amongwhichglycoproteinVI(GPVI)andprotease-activatedreceptors,respectively,aretheessentialones.Inmice,targetingofGPVIwiththemonoclonalantibodyJAQ1inducesdepletionofthereceptorfromcirculatingplatelets,resultinginabolishedcollagenresponsesandlong-lastin...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第7期第一章 白細胞分化抗原--第一節 白細胞分化抗原的分類
...結合vWFCD42c Pt,Meg22,血小板GPIb-β CD42d Pt,Meg85,血小板GPV CD43OTH71C5,G19-1;(Leukosialin)T,G,Mgp95,SialophorinT細胞活化?與CD54結合 續表3CD常用況隆抗體或代號()主要表達細胞分子量(kDa)和結構功能CD44GRHL1,Hermes,F10-44-2(Pgp-1,ECM-RⅢ)...
醫源資料庫;醫源圖書館;教材類;細胞和分子免疫學Mindingthegapstopromotethrombusgrowthandstability
...-1(38).LossofPECAM-1expressioninmiceincreasesresponsivenesstocollagenviatheGPVIcollagenreceptor,consistentwithamodelinwhichplateletactivationleadstotyrosinephosphorylationofPECAM-1,allowingSHP-1/2tobindandbringingthephosphatasenearitssubstrates,includingtheFcchainpartnerofGPVI(39,40).Thismaynormally...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第12期