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Protectionfromcytomegalovirusaftertransplantationiscorrelatedwithimmediateearly1–specificCD8Tcells
...elatesofprotectionfromCMVdiseasehavenotbeendefined.However,responsestothepp65proteinarebelievedtoplayanimportantrole.Here,theproportionsofinterferon–producingTcellsfollowingexvivoactivationwithpoolsofoverlappingpeptidesrepresentingthepp65andimmediateearly(IE)-1proteinsweredeterminedatmultipletimep...
醫源資料庫；在線期刊；實驗醫學雜誌；2005年第201卷第7期 -
DiminishedReplicativeFitnessofPrimaryHumanImmunodeficiencyVirusType1IsolatesHarboringtheK65RMutation
...mmunodeficiencyvirustype1(HIV-1)reversetranscriptase(RT)resistancemutationK65RconfersintermediatelevelsofresistancetoseveralRTinhibitors,includingathree-tofourfoldreductionoftenofovirsusceptibility.Here,wehaveusedforthefirsttimeprimaryHIV-1isolatesfromindividualswhodevelopedtheK65Rmutationwhileenrol...
醫源資料庫；在線期刊；微生物臨牀雜誌；2005年第43卷第3期 -
全腦缺血-再灌注對海馬CA1區GAD65表達的影響及意義*
...摘要】目的探討全腦缺血-再灌注對成年大鼠海馬CA1區GAD65表達的影響及意義。方法成年雄性SD大鼠24只，隨機分爲3組：假手術組（SH）、缺血-再灌注3天組（IR-3）及缺血-再灌注7天組（IR-7），每組8只。採用四動脈阻斷法制作全腦...
醫源資料庫；在線期刊；中華現代外科學雜誌；2008年第5卷第1期 -
NeurotensinStimulatesInterleukin-8ExpressionthroughModulationofIBPhosphorylationandp65TranscriptionalActivity:InvolvementofProteinKinaseC
....Inthisstudy,wefirstshowthatNTstimulatesIBphosphorylationanddegradationandp65phosphorylationandtranscriptionalactivity.InhibitionofproteinkinaseC(PKC)activationsignificantlyattenuatesNT-inducedIL-8expression.ThiseffectseemstobemediatedthroughinhibitionofIBphosphorylationanddegradationandbyp65phospho...
醫源資料庫；在線期刊；分子藥理學雜誌；2005年第67卷第6期 -
DualPathwaysforNuclearFactorBActivationbyAngiotensinIIinVascularSmoothMuscle
...forvascularinflammation.WereportthatAngIIactivatesNF-Bbyphosphorylatingitsp65subunitviaapathwaymediatedpartiallybyribosomalS6kinase(RSK).Ininvestigatingotherpathway(s)thatmaybeinvolved,wefoundthattheabilityofAngIItoactivateNF-Binmouseembryonicfibroblastissuppressed(70%)eitherbydeletionofIBKinase(IKK...
醫源資料庫；在線期刊；循環研究雜誌；2005年第95卷第11期 -
男性服刑在押犯65例服刑能力鑑定
...性服刑在押犯罹患精神疾病與服刑能力的關係。方法：對65例男性服刑在押犯人的司法鑑定資料進行回顧性統計分析。結果：65例中被鑑定患有精神分裂症、偏執性精神病、躁狂抑鬱症者有46例（70.8%），均被評定爲無服刑能力；...
醫源資料庫；在線期刊；中國民康醫學；2008年第20卷第17期 -
ProtectiveEffectoftheKCNMB1E65KGeneticPolymorphismAgainstDiastolicHypertensioninAgingWomenandItsRelevancetoCardiovascularRisk
...na,SpainUniversitatAute皀omadeBarcelona(J.M.),Barcelona,Spain.AbstractTheE65Kpolymorphisminthe1-subunitofthelarge-conductance,Ca2+-dependentK+(BK)channel,akeyelementinthecontrolofarterialtone,hasrecentlybeenassociatedwithlowprevalenceofdiastolichypertension.Wenowreportthemodulatoryeffectofsexandage...
醫源資料庫；在線期刊；循環研究雜誌；2005年第95卷第12期 -
去勢雄兔乾眼症模型淚腺組織NFκBp65亞基及NOS2表達
【摘要】目的檢測NF²κBp65亞基（NFκBp65）和誘導型一氧化氮合成酶（NOS2）在去勢雄兔乾眼症模型淚腺組織的表達，探討其與乾眼症發病的關係。方法制作6只去勢雄兔乾眼症模型,採用免疫組織化學SP方法對模型兔及6只對照兔淚腺...
醫源資料庫；在線期刊；齊魯醫學雜誌；2009年第24卷第1期 -
PotentialContributionofNF-BinNeuronalCellDeathintheGlutathionePeroxidase-1KnockoutMouseinResponsetoIschemia-ReperfusionInjury
...sientMCAOandreperfusionbyintraluminalsutureblockade.Proteinexpressionofthep65subunitoftranscriptionfactornuclearfactor-B(NF-B)wasexaminedbyimmunohistochemistryandWesternAnalysis.NF-BDNA-proteinactivitywasassessedbyelectrophoreticmobilityshiftassays(EMSA).Wild-typeandGpx1–/–micewereexposedtoMCAOw...
醫源資料庫；在線期刊；中風學雜誌；2006年第37卷第6期 -
EriocalyxinBInhibitsNuclearFactor-BActivationbyInterferingwiththeBindingofBothp65andp50totheResponseElementinaNoncompetitiveManner
...ucleartranslocationofthetranscriptionfactor.Down-regulationoftheendogenousp65proteinsensitizedthecellstowardtheactionofthecompound.Furthermore,invitrobindingassayssuggestedthatEri-Breversiblyinterferedwiththebindingofp65andp50subunitstotheDNAinanoncompetitivemanner.Insummary,thisstudyrevealsthenovel...
醫源資料庫；在線期刊；分子藥理學雜誌；2006年第68卷第12期