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ScreeningforvitaminB-12andfolatedeficiencyinolderpersons
...dKingdom.E-mail:robert.clarke{at}ctsu.ox.ac.uk.ABSTRACTBackground:VitaminB-12deficiencyisusuallyaccompaniedbyelevatedconcentrationsofserumtotalhomocysteine(tHcy)andmethylmalonicacid(MMA).FolatedeficiencyalsoresultsinelevatedtHcy.MeasurementofthesemetabolitescanbeusedtoscreenforfunctionalvitaminB-12o...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2003年77卷第5期 -
Adailyintakeofapproximately6µgvitaminB-12appearstosaturateallthevitaminB-12–relatedvariablesinDanishpostmenopausalwomen
...kurbor{at}hotmail.com.ABSTRACTBackground:RecommendeddailyintakesofvitaminB-12varybetween2and6µg.Objective:TheobjectivewastoexaminetheassociationsbetweenvitaminB-12intakeandmarkersofvitaminB-12deficiency.Design:Westudied98Danishpostmenopausalwomenaged41–75y.Serumcobalamin,transcobalamin(TC)...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2006年83卷第1期 -
VitaminB-12metabolisminHIV-infectedpatientsintheageofhighlyactiveantiretroviraltherapy:roleofhomocysteineinassessingvitaminB-12status
...antiretroviraltherapy(HAART),20%and10%ofHIV-infectedpatientshadlowvitaminB-12andredbloodcellfolate(RBCF)concentrations,respectively.However,fewpatientshadrealvitaminB-12deficiency.Objective:WeevaluatedtheprevalenceoflowvitaminB-12andRBCFconcentrationsinHIV-infectedpatientsreceivingHAARTandtheusefuln...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2003年77卷第2期 -
Ala12variantoftheperoxisomeproliferator-activatedreceptor-gene(PPARG)isassociatedwithhigherpolyunsaturatedfatinadiposetissueandattenuatest
...disease.Lessisknownaboutthegeneticvariationmodulatingthisassociation.TheAla12alleleoftheperoxisomeproliferator-activatedreceptor-gene(PPARG)decreasesthelipolysisoftriacylglycerolsinadiposetissue,whichresultsintheaccumulationoffattyacidsinadipocytes.Objective:WeaimedtodeterminewhetherthePro12Alapolym...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2007年86卷第4期 -
DomainsNecessaryforG12BindingandStimulationofProteinPhosphatase-2A(PP2A):IsG12aNovelRegulatorySubunitofPP2A?
...),awidelyexpressedserine/threoninephosphatase,andtheheterotrimericGproteinG12.PP2Aactivityisalteredincarcinogenesisandinsomeneurodegenerativediseases.WehaveidentifiedbindingofG12withtheAsubunitofPP2A,atrimericenzymecomposedofA(scaffolding),B(regulatory),andC(catalytic)subunitsanddemonstratedthatG12s...
醫源資料庫；在線期刊；分子藥理學雜誌；2007年第69卷第5期 -
VegetarianismandvitaminB-12(cobalamin)deficiency
...2),whosesustainedinvestigationsofclinicallyrelevantissuesrelatedtovitaminB-12,folate,andone-carbonmetabolismearnedhimrespect,admiration,andstatusasoneofthegiantsinthisfield.(Internet:http://www.victorherbert.com,accessed4March2003.)3SupportedbyNIHgrantsR01CA58919andR01HD39295andbyaVeteransAffairsMer...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2003年78卷第1期 -
TheEffectsofLeukocyte-Type12/15-LipoxygenaseonId3-MediatedVascularSmoothMuscleCellGrowth
...801394,Charlottesville,VA22908.E-mailcam8c@virginia.eduAbstractObjective—12/15-Lipoxygenase(12/15-LO)hasbeenimplicatedinthepathogenesisofvasculardisease.Vascularsmoothmusclecell(VSMC)proliferationisakeycomponentoftheresponsetoinjuryinvasculardisease.Theroleof12/15-LOinregulatingVSMCproliferationis...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2005年第25卷第10期 -
ProportionofindividualswithlowserumvitaminB-12concentrationswithoutmacrocytosisishigherinthepost–folicacidfortificationperiodthanin
...m.ABSTRACTBackground:LargeintakesoffolicacidmaydelaythediagnosisofvitaminB-12deficiency,whichcouldleadtoirreversibleneuropathy.Objective:TheobjectiveofthisstudywastodeterminewhethertheproportionofindividualswithlowserumvitaminB-12withoutmacrocytosis(undiagnosedvitaminB-12deficiency)hasincreasedinthe...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2007年86卷第4期 -
HSPA12BIsPredominantlyExpressedinEndothelialCellsandRequiredforAngiogenesis
【摘要】Objective-HSPA12BisthenewestmemberofHSP70familyofproteinsandisenrichedinatheroscleroticlesions.ThisstudyfocusedonHSPA12Bexpressioninmiceanditsinvolvementinangiogenesis.MethodsandResults-TheexpressionofHSPA12Binmiceandculturedcellswasstudiedby:(1)Northernblot;(2)insituhybridization;(3)imm...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2006年第26卷第9期 -
AssessingtheassociationbetweenvitaminB-12statusandcognitivefunctioninolderadults
...406.Itiswellestablishedthattheclinicalmanifestationsofovert,severevitaminB-12deficiencyincludebothhematologic(macrocyticormegaloblasticanemia)andneurologic(subacutecombineddegenerationofthespinalcord,peripheralneuropathy,cognitiveimpairment)sequelae.Theneurologicconsequencesareofparticularconcern,be...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2006年84卷第6期