IntersectinRegulatesEpidermalGrowthFactorReceptorEndocytosis,Ubiquitylation,andSignaling
...3ubiquitinligaseCbl.ITSNformsacomplexwithCblinvivomediatedbytheSrchomology(SH)3domainsbindingtothePro-richCOOHterminusofCbl.ThisinteractionstimulatestheubiquitylationanddegradationoftheactivatedEGFR.Furthermore,silencingITSNbyRNAinterferenceattenuatedEGFRinternalizationaswellasactivationoftheextrace...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第11期CriticalRoleforSphingosineKinase-1inRegulatingSurvivalofNeuroblastomaCellsExposedtoAmyloid-βPeptide
...mide/sphingosine1-phosphate(S1P)biostat,intheregulationofdeathandsurvivalofSH-SY5Yneuroblastomacellsinresponsetoamyloidβ(Aβ)peptide(25-35).UponincubationwithAβ,SH-SY5Ycellsdisplayedamarkeddown-regulationofSphK1activitycoupledwithanincreaseintheceramide/S1Pratiofollowedbycelldeath.This...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第8期DiscoveryofaNovelShp2ProteinTyrosinePhosphataseInhibitor
【關鍵詞】DiscoveryShp2isanonreceptorproteintyrosinephosphatase(PTP)encodedbythePTPN11gene.Itisinvolvedingrowthfactorinducedactivationofmitogen-activatedprotein(MAP)kinasesErk1andErk2(Erk1/2)andhasbeenimplicatedinthepathogenicityoftheoncogenicbacteriumHelicobacterpylori.Moreover,gain-of-functio...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第8期氣交變大論篇第六十九
...子之言歲候,不及其太過,而上應五星。今夫德化政令,災眚變易,非常而有也,卒然而動,其亦爲之變乎?岐伯曰:承天而行之,故無妄動,無不應也。卒然而動者,氣之交變也,其不應焉。故曰:應常不應卒,此之謂也。帝曰...
醫源資料庫;醫源圖書館;中醫古籍;黃帝內經·素問Theactincytoskeletonfacilitatescomplement-mediatedactivationofcytosolicphospholipaseA
...tionLaboratories(Lexington,KY).Rabbitanti-cPLA2andrabbitanti-EGF-Rantibodieshavebeendescribedpreviously(9,23).Anagarose-conjugatedfusionproteinconsistingofGSTandtheSH2andSH3domainsofPLC-1(PLC-1-SH2-SH2-SH3)waspurchasedfromSantaCruzBiotechnology(SantaCruz,CA).Electrophoresisandimmunoblottingreagentsw...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第3期復(卦二十四)
...曰:“敦復無悔,中以自考也。上六,迷復,兇,有災眚。用行師,終有大敗,以其國君兇,至於十年不克徵。《象》曰:“迷復之兇,反君道也。作者:佚名
醫源資料庫;醫源圖書館;中醫古籍;周易小過(卦六十二)
...雲不雨,已上也。上六,弗遇過之,飛鳥離之,兇,是謂災眚。《象》曰:“弗遇過之,已亢也。作者:佚名
醫源資料庫;醫源圖書館;中醫古籍;周易AS擴血管機制的研究
...變時,內源性NO·生成不足,硝酸酯可提供外源性NO·,與-SH結合成R·SNO,然後激動血管平滑肌細胞內鳥苷酸環化酶使GTP轉化爲cGMP,興奮cGMP-依賴蛋白激酶,改變細胞中各種蛋白質的磷酸化,使肌凝蛋白輕鏈去磷酸化而產生平滑肌...
合作平臺;在線期刊;中華實用醫藥雜誌;2004年第4卷第17期;論著貴人行樂之法
...理的各種紛繁事務。③縈(yíng):牽掛。④推諉(wěi):把責任推給別人。諉:推託;推卸。⑤擯(bìn)棄:排斥拋棄。⑥冗:繁忙,繁瑣。⑦矢口:謂開口、隨口之意。⑧退一步:指爲人處世禮讓三分,莫與人爭...
醫源資料庫;醫源圖書館;中醫古籍;頤養SOCS2negativelyregulatesgrowthhormoneactioninvitroandinvivo
...ssivegrowthphenotypecharacterizedbya30–50%increaseinmaturebodysize.HereweshowthattheSOCS2–/–phenotypeisdependentuponthepresenceofendogenousgrowthhormone(GH)andthattreatmentwithexogenousGHinducedexcessivegrowthinmicelackingbothendogenousGHandSOCS2.Thiswasreflectedintermsofoverallbodyweight,body...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第2期