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TheEffectsofLeukocyte-Type12/15-LipoxygenaseonId3-MediatedVascularSmoothMuscleCellGrowth
...801394,Charlottesville,VA22908.E-mailcam8c@virginia.eduAbstractObjective—12/15-Lipoxygenase(12/15-LO)hasbeenimplicatedinthepathogenesisofvasculardisease.Vascularsmoothmusclecell(VSMC)proliferationisakeycomponentoftheresponsetoinjuryinvasculardisease.Theroleof12/15-LOinregulatingVSMCproliferationis...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2005年第25卷第10期 -
ProportionofindividualswithlowserumvitaminB-12concentrationswithoutmacrocytosisishigherinthepost–folicacidfortificationperiodthanin
...m.ABSTRACTBackground:LargeintakesoffolicacidmaydelaythediagnosisofvitaminB-12deficiency,whichcouldleadtoirreversibleneuropathy.Objective:TheobjectiveofthisstudywastodeterminewhethertheproportionofindividualswithlowserumvitaminB-12withoutmacrocytosis(undiagnosedvitaminB-12deficiency)hasincreasedinthe...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2007年86卷第4期 -
HSPA12BIsPredominantlyExpressedinEndothelialCellsandRequiredforAngiogenesis
【摘要】Objective-HSPA12BisthenewestmemberofHSP70familyofproteinsandisenrichedinatheroscleroticlesions.ThisstudyfocusedonHSPA12Bexpressioninmiceanditsinvolvementinangiogenesis.MethodsandResults-TheexpressionofHSPA12Binmiceandculturedcellswasstudiedby:(1)Northernblot;(2)insituhybridization;(3)imm...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2006年第26卷第9期 -
AssessingtheassociationbetweenvitaminB-12statusandcognitivefunctioninolderadults
...406.Itiswellestablishedthattheclinicalmanifestationsofovert,severevitaminB-12deficiencyincludebothhematologic(macrocyticormegaloblasticanemia)andneurologic(subacutecombineddegenerationofthespinalcord,peripheralneuropathy,cognitiveimpairment)sequelae.Theneurologicconsequencesareofparticularconcern,be...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2006年84卷第6期 -
白細胞介素12及其抗腫瘤作用
IL-12是新近發現的一種細胞因子，具有多種生物學活性，尤其是在抗腫瘤免疫和抗病毒免疫中有重要的作用。 一、IL-12概況 IL-12主要來源於單核/巨噬細胞、抗原遞呈細胞和B細胞，是由相對分子質量爲40×103和35×103兩個亞...
合作平臺；醫學論文；外科論文；普通外科學 -
EffectoforalvitaminB-12withorwithoutfolicacidoncognitivefunctioninolderpeoplewithmildvitaminB-12deficiency:arandomized,placebo-controll
...tQLK3-CT-2002-01775fromtheFoundationtoPromoteResearchIntoFunctionalVitaminB12DeficiencyandtheEuropeanUnionBIOMEDDemonstrationProject;andgrant2004-E2fromtheNutriciaHealthFoundation,Wageningen,Netherlands.3AddressreprintrequeststoLCdeGroot,DivisionofHumanNutrition,WageningenUniversity,POBox8129,6700EV...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2006年84卷第2期 -
TransgenicOverexpressionofADAMSuppressesMuscleRegenerationandAggravatesDystrophyinAgedmdxMice
...rationandgradualreplacementoftheskeletalmusclebyfatandconnectivetissue.ADAM12haspreviouslybeenshowntoalleviatethepathologyofyoungdystrophin-deficientmdxmice,amodelforDuchennemusculardystrophy.TheobservedeffectofADAM12wassuggestedtobemediatedviaamembrane-stabilizingup-regulationofutrophin,7Bintegrin,...
醫源資料庫；在線期刊；美國病理學雜誌；2007年第169卷第11期 -
MMP-12與動脈粥樣硬化
...Collagenases(MMP-1,-8,-13)Gelatinases(MMP-2,-9)Stromelysins(MMP-3,-10,-11,-12)Membrane-typeMMPs(MMP-14~17and-24~25)Others:matrilysin(MMP-7,-19-24,-26)TheFunctionsofMMPsPhysiological:EmbryonicdevelopmentOrganmorphogenesisNervegrowthBoneremodelingWoundhealingOvulationAngiogenesisPathological:Emphysema...
醫源資料庫；醫學文檔庫；心血管相關 -
2009國家自然科學基金項目（生物類）
...學170人類NADPHsensor蛋白HSCARG調控機制研究鄭曉峯30930020/C05012010-01至2013-12北京大學180結構修飾的siRNA合成和RNA干擾技術在藥物靶標尋找中的研究張禮和20932001/B0207022010-01至2013-12北京大學180p53和PTEN之間的分子聯繫研究尹玉新30930021/C05...
醫學教育；科教新聞 -
RemovalofFkbp12/12.6FromEndothelialRyanodineReceptorsLeadstoanIntracellularCalciumLeakandEndothelialDysfunction
【摘要】Objectives-FK506BindingProtein12anditsrelatedisoform12.6(FKBP12/12.6)stabilizeaclosedstateofintracellularCa2+releasechannels(ryanodinereceptors),andinmyocytesremovalofFKBP12/12.6fromRyRsaltersintracellularCa2+levels.TheimmunosuppressivedrugsrapamycinandFK506bindanddisplaceFKBP12/12.6from...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2007年第27卷第7期