全顱常規外照射對大鼠血腦脊液屏障上Pgp和MRP1表達的影響及意義
...觀察,毛細血管內皮細胞的細胞膜和細胞漿中出現棕黃色顆粒狀染色爲陽性。高倍鏡下每一切片取5個視野,每個視野各計數100個細胞,計數陽性細胞數,同時測累計吸光度值(A),判斷血管內皮細胞上Pgp及MRP1的表達情況。 ...
醫源資料庫;在線期刊;齊魯醫學雜誌;2008年第23卷第2期FunctionalValidationoftheGeneticPolymorphismsofHumanATP-BindingCassette(ABC)TransporterABCG2:IdentificationofAllelesThatAreDefectiveinPorp
...s(SNP)ofABCG2.Inthepresentstudy,basedonthecurrentlyavailabledataonSNPsandacquiredmutations,wehavecreatedatotalof18variantformsofABCG2(V12M,G51C,Q126stop,Q141K,T153M,Q166E,I206L,F208S,S248P,E334stop,F431L,S441N,R482G,R482T,F489L,F571I,N590Y,andD620N)bysite-directedmutagenesisandexpressedthemininsectc...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第7期Identifyinggenesthatregulateboneremodelingaspotentialtherapeutictargets
...tal,Boston,MA02129.Boneremodeling,acoupledprocessinvolvingboneresorptionandformation,isinitiatedbymechanicalsignalsandiscontrolledbylocalandsystemicfactorsthatregulateosteoblastandosteoclastdifferentiationandfunction.Anexcessofresorptionoverformationleadstothebonelossandincreasedpropensitytofracture...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第6期Autoimmunearthritisassociatedwithmutatedinterleukin(IL)-6receptorgp130isdrivenbySTAT3/IL-7–dependenthomeostaticproliferationofCD4+Tcells
...amilycytokines.InspiteofthenecessityforCD4+Tcells,thegp130mutationwasonlyrequiredinnonhemtopoieticcellsforthedisease.Thegp130mutationresultedinenhancedproductionofIL-7.ConditionalknockoutofSTAT3innonlymphoidcellsshowedthattheenhancementofIL-7productionwasdependentonSTAT3activationbyIL-6familycytokin...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第6期AID-dependenthistoneacetylationisdetectedinimmunoglobulinSregions
...strandbreak;GLT,germlinetranscript;NHEJ,nonhomologousendjoining;P,promoter;q,quantitative;RPA,replicationproteinA;ss,singlestranded;SHM,somatichypermutation.Immunoglobulinclassswitchrecombination(CSR)involvesanintrachromosomaldeletionalrearrangementthatfocusesonregionsofrepetitiveswitch(S)DNAlocated...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第1期學術報告:GeneticDissectionoftheSenseofSmell
題目:GeneticDissectionoftheSenseofSmell主講人:鄒志華副教授美國德克薩斯大學醫學分校神經與細胞生物學系主持人:劉先國教授中山大學中山醫學院副院長時間:2007年11月22日(星期四)下午14:30時地點:中山大學北校區大外賓接...
醫學教育;校園動態;中山醫科大學(中山大學廣州北校區)NorovirusesasaCauseofTraveler‘sDiarrheaamongStudentsfromtheUnitedStatesVisitingMexico
SeoulNationalUniversity,SchoolofPublicHealth,InstituteofHealthandEnvironment,Seoul,SouthKoreaUniversityofTexas—HoustonSchoolofPublicHealthMedicalSchoolBaylorCollegeofMedicineSt.Luke‘sEpiscopalHospital,Houston,TexasInstitutoNacionaldeSaludPublica,Cuernavaca,MexicoCentersforDiseaseControlandPreven...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第12期Lightchaineditinggeneratespolyreactiveantibodiesinchronicgraft-versus-hostreaction
1DepartmentofPathology,GwenKnappCenterforLupusandImmunologyResearch,UniversityofChicago,Chicago,IL606372LaboratoryofMolecularGeneticsandImmunology,TheRockefellerUniversity,NewYork,NY10021Thechronicgraft-versus-host(cGvH)reactionisamodelofinducedlupuscausedbyalloreactiveCD4+TcellsfromaBm-12mouseinaC5...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第7期SingleNucleotidePolymorphismsintheHumanNorepinephrineTransporterGeneAffectExpression,Trafficking,AntidepressantInteraction,andProteinKinaseC
...videnceofitsdysfunctionindisease,anditsroleasatargetfortherapeuticsraisethequestionofwhetheralterationsinNEhomeostasisordrugresponsederivefromhNETgeneticvariation.AnumberofhNETpromoter,intron,andcoding-regionpolymorphismshavebeenidentifiedeitherthroughdiscovery-orientedstudiesofhNETinvariousclinical...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第2期檢測數據處理基礎知識
...值,而是要經過計算、比較才能確定,我們用的方法就叫Q檢驗法。 2.檢驗方法 (1)求Q:Q= 即:求出離羣值與其最鄰近的一個數值的差,再將它與極差相比就得Q值。 (2)比較:根據測定次數n和置信度查Q,若Q>...
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