LeukotrieneB4,anactivationproductofmastcells,isachemoattractantfortheirprogenitors
...omedicalSciencesDivision,FacultyofMedicine,ImperialCollegeLondon,SouthKensington,LondonSW72AZ,England,UK2DepartmentofVeterinaryClinicalStudies,UniversityofEdinburgh,EasterBushVeterinaryCentre,Roslin,Midlothian,EH259RG,Scotland,UKMastcellsaretissue-residentcellswithimportantfunctionsinallergyandinfla...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第12期TheBRAF–MAPKsignalingpathwayisessentialforcancer-immuneevasioninhumanmelanomacells
DivisionofCellularSignaling,InstituteforAdvancedMedicalResearch,KeioUniversitySchoolofMedicine,Tokyo160-8582,JapanThemitogen-activatedproteinkinase(MAPK)pathwayisfrequentlyactivatedinhumancancers,leadingtomalignantphenotypessuchasautonomouscellularproliferation.Here,wedemonstrateanovelroleoftheactiv...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第7期新一代抗真菌藥拉諾康唑
...nazole)、氟康唑、伊曲康唑和拉諾康唑(lanoconazole)等。然而抗藥性的產生是當今抗感染藥物研究中表現十分嚴重的問題,特別是多重抗藥性問題(MDR),這些藥物既可以是結構相似的同類藥物,也可以是結構不同、來源不一的...
醫源資料庫;在線期刊;中華實用醫藥雜誌;2009年第9卷第5期高效液相色譜法測定異維A酸的血藥濃度
...後在紫外365nm處檢測。結果:血藥濃度標準曲線在10~500ng.mL-1,r=0.9999,最低檢測限爲10ng.mL-1,高、中、低3種濃度平均回收率爲81.62%~88.99%。日內和日間平均RSD小於0.61%和8.20%。結論:本法可爲異維A酸的藥動學研究提供檢測方法...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文l-CaldesmonRegulatesProliferationandMigrationofVascularSmoothMuscleCellsandInhibitsNeointimalFormationAfterAngioplasty
【摘要】Objective-Light-typecaldesmon(l-CaD)isapotentcytostaticandantiangiogenicproteinthatregulatescellgrowthandsurvivalviamodulationofthecellshapeandcytoskeleton.Theaimofthisstudyistoexplorethepotentialvalueofl-CaDforuseasacytostaticagenttoinhibitneointimalformationafterangioplastybysuppressin...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第10期InvolvementofTissuePlasminogenActivator-PlasminSysteminDepolarization-EvokedDopamineReleaseintheNucleusAccumbensofMice
...h)releaseinthenucleusaccumbens(NAc)andhippocampus,respectively,ofmice,byusinginvivomicrodialysis.MicroinjectionofeithertPAorplasminsignificantlypotentiated40mMKCl-inducedDAreleasewithoutaffectingbasalDAlevels.Incontrast,plasminogenactivatorinhibitor-1dose-dependentlyreduced60mMKCl-inducedDArelease.T...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第11期Postnatalacquisitionofendotoxintoleranceinintestinalepithelialcells
....Here,weusedhighlyenrichedprimaryIECstoanalyzeToll-likereceptor(TLR)signalingandmechanismsthatpreventinappropriatestimulationbythecolonizingmicroflora.Althoughthelipopolysaccharide(LPS)receptorcomplexTLR4/MD-2waspresentinfetal,neonatal,andadultIECs,LPS-inducednuclearfactorB(NF-B)activationandchemoki...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期替硝唑片在人體內生物等效性的試驗觀察
...代動力學參數Cmax、Tmax、T1/2、AUC0→72分別爲(12.56±3.188)ng/ml、(2.01±1.24)h、(16.03±1.69)h和(257.55±47.46)ng·h/ml與參與制劑的(12.13±2.23)ng/ml、(1.93±0.86)h、(15.79±1.88)h和(257.86±46.41)ng·h/ml差異無顯著性(P0.05)。結論...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2006年第6卷第6期Homocysteine,Bvitamins,andtheincidenceofdementiaandcognitiveimpairment:resultsfromtheSacramentoAreaLatinoStudyonAging
MaryNHaan,JoshuaWMiller,AllisonEAiello,RachelAWhitmer,WilliamJJagust,DanMMungas,LindsayHAllenandRalphGreen1FromtheEpidemiologyProgram,SchoolofPublicHealth,UniversityofMichigan,AnnArbor,MI(MNHandAEA);theDepartmentofMedicalPathologyandLaboratoryMedicine,SchoolofMedicine,UniversityofCalifornia,Davis,Da...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第2期HMG-CoAreductaseinhibitorsimvastatinmitigatesVEGF-inducedinside-outsignalingtoextracellularmatrixbypreventingRhoAactivation
...meA(HMG-CoA)reductaseinhibitorsexertmodulatoryeffectsonanumberofcellsignalingcascadesbypreventingthesynthesisofvariousisoprenoidsderivedfromthemevalonatepathway.Inthepresentstudy,wedescribeanovelpleiotropiceffectofHMG-CoAreductaseinhibitors,alsocommonlyknownasstatins,onvascularendothelialgrowthfacto...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第11期