Age-dependentincidence,timecourse,andconsequencesofthymicrenewalinadults

...parameters.Wethereforetestedthecorrelationsbetweenthemaximumthymicindex,whichusuallywasachievedby1year,andnaiveCD4+Tcellrecovery.Maximumthymicindexwaspredictiveofboththenumberofnaive(CD45RA+CD62L+)CD4+TcellsandthefrequencyofTRECsper105CD4+Tcellsat2years(Figure5,AandB).Wealsofoundastrongcorrelationbe...

ApoptosismodulatesprotectiveimmunitytothepathogenicfungusHistoplasmacapsulatum

...ofinfectiousdiseases.5thedition.G.L.Mandell,J.E.Bennett,andR.Dolin,editors.ChurchillLivingstone.Philadelphia,Pennsylvania,USA.2718–2732..Allendorfer,R.,Brunner,G.D.,andDeepe,G.S.Jr.1999..Complexrequirementsfornascentandmemoryimmunityinpulmonaryhistoplasmosis.J.Immunol.162::7389-7396.Deepe,G.S.Jr.1...

HIF-1–dependentrepressionofequilibrativenucleosidetransporter(ENT)inhypoxia

...v.Immunol.22:657–682.Desai,A.,C.Victor-Vega,S.Gadangi,M.C.Montesinos,C.C.Chu,andB.N.Cronstein.2005.AdenosineA2Areceptorstimulationincreasesangiogenesisbydown-regulatingproductionoftheantiangiogenicmatrixproteinthrombospondin1.Mol.Pharmacol.67:1406–1413.Eltzschig,H.K.,J.C.Ibla,G.T.Furuta,M.O.Leon...

Autoimmunearthritisassociatedwithmutatedinterleukin(IL)-6receptorgp130isdrivenbySTAT3/IL-7–dependenthomeostaticproliferationofCD4+Tcells

...dthemethodminorly.Althoughwehadremovedscoresofdeadmicefromtheassessment,whichusuallyhadhighscores(28,29),here,weputthesamescoresfromthepointoftimeatwhichtheyweremoribundordeaduntilendpointoftheassessmentofthegroups.Thearthritisscoreshownisthesumofthescoresforfourlimbsgradedfrom0to4.Thus,themaximumar...

ImmunostimulatoryoligonucleotidesblockallergicairwayinflammationbyinhibitingTh2cellactivationandIgE-mediatedcytokineinduction

...Boyd,JeffreyTsao,andHectorNollafortechnicalassistance,LorraineSmyserandLinhChuforadministrativehelp,andAliciaChandler,GeoffreyDelRosario,andZobairMusafortheirexcellentassistancewiththeinvivotreatmentprocedures.E.M.Hessel,M.Chu,J.O.Lizcano,B.Chang,S.A.Kell,andR.L.CoffmanwereorarecurrentlyDynavaxTechn...

Estrogenreceptorsandhumandisease

...ingpopulation-basedtrendsincancertreatment.J.Natl.CancerInst.97::1407-1427.Chu,S.,Mamers,P.,Burger,H.G.,andFuller,P.J.2000..Estrogenreceptorisoformgeneexpressioninovarianstromalandepithelialtumors.J.Clin.Endocrinol.Metab.85::1200-1205.Syed,V.,Ulinski,G.,Mok,S.C.,Yiu,G.K.,andHo,S.M.2001..Expressionof...

Intestinalantiinflammatoryeffectof5-aminosalicylicacidisdependentonperoxisomeproliferator–activatedreceptor-

...Medicale(INSERM)0114,PhysiopathologiedesMaladiesInflammatoiresIntestinales,CHU59037Lille,France2INSERMU459,FacultédeMédecine,59045LilleCedex,France3InstitutdeGénétiqueetBiologieMoléculaireetCellulaire,INSERM,CentreNationaldelaRechercheScientifique,UniversitéLouisPasteur,67404Illkirch,France4Ce...

HTLV-1propelsuntransformedCD4+lymphocytesintothecellcyclewhileprotectingCD8+cellsfromdeath

...ot,Lyon,France.3Laboratoired’Hématologie,CentreHospitalierUniversitaire(CHU)d’Angers,Angers,France.4Laboratoired’Immunologie,CHUHenriMondor,Créteil,France.5Unitéd’EpidémiologieetPhysiopathologiedesVirusOncogènes,InstitutPasteur,Paris,France.6ServicedeNeurologie,FondationRothschild,Paris...

CompleteFcRndependenceforintravenousIgtherapyinautoimmuneskinblisteringdiseases

....Figure2HDIGinhibitsexperimentalPFandPVbyacceleratingdegradationofpathogenichumanautoantibodyIgG.NeonatalC57BL/6Jmicewerepretreatedwithbuffer,IgM(12.93mg/gbodyweight),ordifferentdosesofHDIG(0–2mg/gbodyweight)andinjectedi.p.withpathogenicanti-Dsg1IgG(PF1,40μg/gbodyweight)oranti-Dsg3IgG(PV1,50μg/g...

Proteinkinasecascadesintheregulationofcardiachypertrophy

...ufts-NewEnglandMedicalCenterandTuftsUniversitySchoolofMedicine,Boston,Massachusetts,USA.AbstractInbroadterms,thereare3typesofcardiachypertrophy:normalgrowth,growthinducedbyphysicalconditioning(i.e.,physiologichypertrophy),andgrowthinducedbypathologicstimuli.Recentevidencesuggeststhatnormalandexercis...