離子交換色譜法教程
...離子交換劑中的可解離基因是伯胺、(-NH2)、仲胺(-NHCH3)、叔胺[N-(CH3)2]和季胺[-N(CH3)2]等礆性基團。某些交換反應如下: 強礆性:R-N+(CH3)2H·OH-+ClR-N+(CH3)2Cl+OH- 弱礆性:R-N+(CH3)2H·OH-+ClR-N+(CH3)2HCl+OH...
藥品天地;專業藥學;實驗技術;色譜技術;色譜分析實例DistinctProfilesof7nAChRPositiveAllostericModulationRevealedbyStructurallyDiverseChemotypes
【關鍵詞】DistinctSelectivemodulationof7nicotinicacetylcholinereceptors(nAChRs)isthoughttoregulateprocessesimpairedinschizophrenia,Alzheimer‘sdisease,andotherdementias.Oneapproachtotarget7nAChRsisbypositiveallostericmodulation.Structurallydiversecompounds,includingPNU-120596,4-naphthalene-1-y...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第9期InnateimmunityagainstFrancisellatularensisisdependentontheASC/caspase-1axis
1MolecularOncologyDepartment,GenentechInc.,SouthSanFrancisco,CA940802DepartmentofMicrobiologyandImmunology,StanfordUniversitySchoolofMedicine,Stanford,CA94305Francisellatularensisisahighlyinfectiousgram-negativecoccobacillusthatcausesthezoonosistularemia.Thisbacterialpathogencausesaplague-likediseas...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第8期Ironbioavailabilityininfantsfromaninfantcerealfortifiedwithferricpyrophosphateorferrousfumarate
LenaDavidsson,PeterKastenmayer,HannaSzajewska,RichardFHurrellandDenisBarclay1FromtheLaboratoryforHumanNutrition,InstituteofFoodScience,SwissFederalInstituteofTechnology,Rüschlikon,Switzerland;theDepartmentofPediatricGastroenterologyandNutrition,WarsawUniversityMedicalSchool,Dzialdowska,Poland;a...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年71卷第6期NotchSignalingInducesApoptosisandInhibitsHumanMDA-MB-XenograftGrowth
【摘要】Notchfunctionsasanoncogeneortumorinhibitorinvariouscancers,anddecreasesinNotch2expressionareassociatedwithincreasinggradeofhumanbreastcancer.WeconstitutivelyactivatedNotchsignalingwithintracellulardomain(ICD)expressioninthehumanadenocarcinomalineMDA-MB-231.Notch2signalingincreasedapoptos...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第9期LocalizationofUbiquitinC-TerminalHydrolaseLinMouseOvaandItsFunctioninthePlasmaMembranetoBlockPolyspermy
...erapiddegradationofspecificproteins.Ubiquitincarboxyl-terminalhydrolaseL1(UCH-L1)isexclusivelyexpressedinneurons,testis,ovary,andplacenta,eachofwhichhasuniquebiologicalactivities.However,thefunctionalroleofUCH-L1inmouseoocytesremainsunknown.Here,wereporttheexpressionpatternofUCH-L1anditsisozymeUCH-L...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第11期IntracerebralHemorrhageintheIron-DeficientRat
...ent(J.S.,B.F.)andtheDepartmentofNeurosurgery(G.X.,Y.H.,T.S.),UniversityofMichigan,AnnArborDepartmentofPediatricHealthCare,Children’sHospital,ZhejiangUniversitySchoolofMedicine,China(J.S.)DepartmentofPsychology(T.S.),UniversityofTexas,Austin.AbstractBackgroundandPurpose—Ironcontributestobraininju...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第3期UseofDipsticksforRapidDiagnosisofCholeraCausedbyVibriocholeraeO1andO139fromRectalSwabs
...andClinicalSciencesDivisions,InternationalCentreforDiarrhoealDiseasesResearch,Bangladesh(ICDDR,B),Dhaka1212,Bangladesh,1InstitutPasteur,Paris,France,2CERMES,Niamey,Niger3Received13March2003/Returnedformodification9May2003/Accepted20May2003 ABSTRACTTopAbstractTextReferencesWeevaluatedtherecentlydev...
醫源資料庫;在線期刊;微生物臨牀雜誌;2003年第41卷第8期Treg-mediatedimmunosuppressioninvolvesactivationoftheNotch-HES1axisbymembrane-boundTGF-?
...,andCriticalCareMedicine,and2DepartmentofImmunology,UniversityofPittsburghSchoolofMedicine,Pittsburgh,Pennsylvania,USA.AbstractStudiesinhumansandmiceshowanimportantroleforTregsinthecontrolofimmunologicaldisorders.ThemechanismsunderlyingtheimmunosuppressivefunctionsofTregsarenotwellunderstood.Here,we...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第4期UV,HPLC測定紅花中黃色素、多糖和腺苷的含量*
...木薩爾紅花腺苷含量最高。Determinationofsaffloweryellow,polysaccharideandadenosineinCarthamustinctoriusbyUVandHPLCGuoMeili(GuoML),FuLibo(FuLB),ZhangZhiyu(ZhangZY),etal(CollegeofPharmacy,SecondMilitaryMedicalUniversity,Shanghai200433)ABSTRACT OBJECTIVE:Toprovidethequatitybasisforthecrude...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文