Geneticvariationandthelipidresponsetodietaryintervention:asystematicreview
...licting.Futurestudiesneedtohavemuchlargersamplesizesbasedonpowercalculationsandcarefullycontrolleddietaryinterventionsandshouldinvestigatetheeffectsofpolymorphismsinmultiplegenesinsteadoftheeffectsofpolymorphismsinsinglegenes.KeyWords:Polymorphismgenotypedietlipidslipoprotein...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2003年77卷第5期Originofatherosclerosisinchildhoodandadolescence
...sisinYouth(PDAY)ResearchGroup1FromtheUniversityofTexasHealthScienceCenteratSanAntonio;theSouthwestFoundationforBiomedicalResearch,SanAntonio,TX;TheOhioStateUniversity,Columbus;andtheLouisianaStateUniversityMedicalCenter,NewOrleans.2PresentedatthesymposiumFatIntakeDuringChildhood,heldinHouston,June8&...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年72卷第5期PlateletsandChemokinesinAtherosclerosis
...asinglyevidentthatbloodplateletsdonotonlyexertimportantfunctionsinhemostasisandthrombusformationbutarealsoinvolvedinatheroscleroticvasculardisease.Amajorportionoftheunderlyingmechanismsisrelatedtoanintricatefunctionalinteractionofplateletswithchemokines,whichhavealsobeenimplicatedinatherogenesisandn...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第4期Antioxidantsprotectfromatherosclerosisbyahemeoxygenase-1pathwaythatisindependentoffreeradicalscavenging
...es.Astrikingexceptionisprobucol,whichretardsatherosclerosisincarotidarteriesandrestenosisofcoronaryarteriesafterangioplasty.Becauseprobucolhasinvitrocellular-protectiveeffectsindependentofinhibitinglipidoxidation,weinvestigatedthemodeofactionofprobucolinvivo.Weusedthreemodelsofvasculardisease:apolip...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期Endomucin,aCD34-likesialomucin,markshematopoieticstemcellsthroughoutdevelopment
...c-Kit+Sca-1+Lin–(CD34–KSL)HSCs.Oneoftheidentifiedmolecules,Endomucin,isanendothelialsialomucincloselyrelatedtoCD34.High-levelexpressionofEndomucinwasconfinedtotheBMKSLHSCsandprogenitorcells,and,importantly,long-termrepopulating(LTR)–HSCswereexclusivelypresentintheEndomucin+CD34–KSLpopulation...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第11期AcuteRespiratoryDistressSyndrome
...ysicianspracticingtoday,itisdifficulttorememberatimebeforeintensivecareunitsandmechanicalventilators.ThisarticlewillprovideabriefhistoryofthedevelopmentofthecurrentconceptsregardingthepathophysiologyofARDS,asummaryofcurrentmanagementoptions,andabriefdiscussionoffuturedirections.ARDS:THEEARLYHISTORYT...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第10期SingleMutationsatAsn295andLeu305intheCytoplasmicHalfofTransmembrane-HelixDomain7oftheAT1ReceptorInducePromiscuousAgonistSpecificityfor
...itsspecificnativeagonist(s).Inthisstudy,weshowedthattwopointmutationsofN295SandL305QenabledtheAT1receptorstorecognizemultipleAngIIfragments.SimilartothewellestablishedconstitutivelyactiveAT1mutantreceptorN111G,themutationsofN295SandL305Qinducedanincreasedproductionofbasalinositol1,4,5-phosphatesinth...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第2期Bmi-IsEssentialfortheTumorigenicityofNeuroblastomaCells
...umancancers.Inneuroblastoma,amplificationoftheoncogeneMYCNoccursin22%ofcasesandisassociatedwithadvancedstagesofthediseaseandpoorprognosis.Identificationofotheroncogenesthatareconsistentlymutatedoroverexpressedinneuroblastomaiscrucialforamolecularunderstandingofthepathogenicprocess.Here,wereportthatt...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第4期Bloodgrouprelatedantigensinocularcicatricialpemphigoid
...xpressioninocularcicatricialpemphigoid(OCP)accordingtothedistributionofLewisandsecretorphenotypesinOCPpatientscomparedtonormalsubjects.Methods:Immunostainingwasperformedonconjunctivalbiopsyspecimensfrom22consecutivepatientssufferingfromOCP,usingmonoclonalantibodies(Mabs)directedagainstthepeptidiccor...
醫源資料庫;在線期刊;英國眼科學雜誌;2004年第88卷第10期EffectofHepatitisCVirusGenotypeonCD4+TCellCountinaCohortofAntiretroviral-NaiveHIV-1InfectedIndividuals
...InfectiousDiseases,CatholicUniversityofSacredHeart,RomeInstituteofInfectiousandTropicalDiseases,UniversityofMilan,Milan,ItalyDepartmentofPrimaryCareandPopulationSciences,RoyalFreeandUniversityCollegeMedicalSchool,London,UnitedKingdomOverthepastfewyears,therehasbeensubstantialcontroversyregardingwhet...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第16期