Incorporationoftheβ3SubunitHasaDominant-NegativeEffectontheFunctionofRecombinantCentral-TypeNeuronalNicotinicReceptors
...ce.CappedcRNAwastranscribedusingtheSP6mMessagemMachineKit(Ambion,Cambridge,UK)andcheckedbyRNAelectrophoresis.Two-ElectrodeVoltage-ClampRecordingofX.laevisOocytes.FemaleX.laevisfrogswereanesthetizedbyimmersioninneutralizedethylm-aminobenzoatesolution(tricaine,methanesulfonatesalt;0.2%solution,w/v)and...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第10期ERKpandSmadSignalingPathwaysDifferentiallyRegulateTransformingGrowthFactor-ßAutoinductioninProximalTubularEpithelialCells
...idase-conjugatedsecondaryantibodyfromSantaCruzBiotechnology,Inc.(Wiltshire,UK);andanti-c-MycpolyclonalantibodyfromSigma(Poole,UK).Forsupershiftassays,polyclonalrabbitanti-c-fos,c-Junantibodies,andanti-p50,anti-p52,anti-p65,anti-C-Rel,andanti-Rel-BantibodieswereallpurchasedfromSantaCruzBiotechnology,...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第10期InvivostimulationofapicalP2receptorsincollectingducts:evidenceforinhibitionofsodiumreabsorption
...-sodiumdiet(Na+content13mmol/kgdryweight;SpecialDietsServices,Witham,Essex,UK;n=32rats)for78days.Theywerethenanesthetizedwithsodiumthiopentone(100mg/kgip;LinkPharmaceuticals,Horsham,Sussex,UK)andpreparedsurgicallyformicropunctureoftheleftkidney(25).Ratsonanormaldietwereinfusedintravenouslythroughout...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第6期新型溶栓劑納豆激酶的研究進展
...]。目前臨牀上治療血栓和栓塞主要是通過注射尿激酶(UK)、鏈激酶(SK)、組織型纖溶酶原激活劑(t-PA)、乙酰化纖溶酶原鏈激酶激活劑(APSAC)和單鏈尿激酶型纖溶酶原激活劑(SCUPA)。這些藥物均爲纖溶酶原激活劑,通過...
醫源資料庫;在線期刊;中華實用醫藥雜誌;2009年第9卷第1期Morquiosyndrome:electronmicroscopicfindings
1DepartmentofOphthalmology,GrampianUniversityTeachingHospitals,Aberdeen,UK2DepartmentofOphthalmology,GartnavelGeneralHospital,Glasgow,UK3DepartmentofOphthalmology,HairmyresGeneralHospital,EastKilbride,UKCorrespondenceto:TLeslieDepartmentofOphthalmology,GrampianUniversityTeachingHospitals,AberdeenAB2...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第7期低分子肝素和小劑量尿激酶溶栓對不穩定型心絞痛治療的療效觀察
...,但不能清除已經形成的血栓及其有機物。而使用小劑量UK即可激活纖溶酶,通過纖溶酶的作用,將新鮮血栓及機化物溶解清除,並隨着劑量的減少其促血栓活性作用亦隨之降低[4]。由於減少了溶栓劑的劑量,同時在溶栓前應...
資料庫;在線期刊;中華現代內科學雜誌;2005年第2卷第6期DetectionandLocalizationofPrPScintheSkeletalMuscleofPatientswithVariantIatrogenicandSporadicFormsofCreutzfeldt-JakobDisease
...ipitation/WesternblottingtechniquetoscreenskeletalandheartmusclesamplesfromUKpatientswithvCJD,iCJD,aswellassCJD.WeshowthatPrPresisindeedpresentinasignificantproportionofautopsyskeletalmusclesamplestakenfromvCJD,iCJD,andsCJDpatients,andwegoontousetheparaffin-embeddedtissue(PET)blottingtechniquetodete...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第3期Retinalracemosehaemangiomadirectlycommunicatingwithaintramuscularfacialcavernoushaemangioma
1WesternEyeHospital,London,UK2MaydayHospital,Croydon,UK3RoyalSurreyCountyHospital,Guildford,UKCorrespondenceto:DGohWesternEyeHospital,London,UK;davidgoh1@aol.comAcceptedforpublication21October2003Keywords:retinalracemosehaemangioma;retinalarteriovenousmalformation;Wyburn-MasonsyndromeThetriadofconco...
醫源資料庫;在線期刊;英國眼科學雜誌;2004年第88卷第6期PPARinhibitsvascularsmoothmusclecellproliferationunderlyingintimalhyperplasiabyinducingthetumorsuppressorp16INK4a
...i-pRBantibodyrecognizingasitespecificallyphosphorylatedbycyclinD1/CDK4(PSer780-ppRB)(28),respectively.(C)Anti-CDK4immunoprecipitateswereassayedforkinaseactivityusingthe769–921pRBfragmentassubstrate(63)(toppanel),oranalyzedbyWesternblotusingspecificanti-p16(middlepanel)oranti-CDK4antibodies(lowerpa...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第11期下肢深靜脈血栓形成的治療體會
...抗凝、祛聚、降纖治療方案。溶栓治療主要採取尿激酶(UK),靜脈給藥。結合患者的情況採用劑量10~25萬u/d,連用7~10天。抗凝治療採用低分子肝素(LMWH)5000u,每天1次皮下注射,連用7天,並且結合患者給予腸溶阿司匹林祛...
合作平臺;在線期刊;中華現代中西醫雜誌;2005年第3卷第10期;論著