ComputationalApproachInvolvingUseoftheInternalTranscribedSpacer1RegionforIdentificationofMycobacteriumSpecies
...://www.ncbi.nlm.nih.gov/)andtheRibosomalDifferentiationofMedicalMicroorganismsdatabase(RIDOM,Würzburg,Germany)(http://www.ridom-rdna.de)wereexaminedfortheavailabilityofMycobacteriumspeciesITS-1sequences.Whenidentified,theITS-1sequenceswereanalyzedbythevalidationprogramasdescribedinthecustomdatabase...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第8期Ca2+/CalmodulineCDependentProteinKinaseModulatesCardiacRyanodineReceptorPhosphorylationandSarcoplasmicReticulumCa2+LeakinHeartFailure
...bitmodel,weshowedthatspontaneouslyoccurringVTinitiatesbynonreentrantmechanisms7associatedwithdelayedafterdepolarizations.2ThesearisefromspontaneousSRCareleasethatactivatesatransientinwardcurrent(Iti)carriedprimarilybyNCX.2ThusabnormalSRCareleaseviaRyRmaycontributetobothcontractiledysfunctionandarrhy...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第12期N-TerminalProteolysisoftheEndothelinBReceptorAbolishesItsAbilitytoInduceEGFReceptorTransactivationandContractileProteinExpressioninVascula
...rvascularinjury,VSMCsmayregainacontractilephenotypethroughyetunknownmechanisms.11Itisnotablethatthrombinviatheprotease-activatedreceptor1(PAR1)12,13andrapamycin,ablockerofthemammaliantargetofrapamycin,inducedifferentiationofVSMCsbyinhibitinggrowthandincreasingtheexpressionofSMmyosinheavychain(SM-MHC...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第6期ArgininevasopressinstimulatesH+-ATPaseinMDCKcellsviaV1(cellCa2+)andV2(cAMP)receptors
...ation.AccordingtoFernándezandMalnic(10),themoreimportantofthemechanismsofpHirecoveryafteranacidloadinstrainIMDCKcellsistheNa+/H+exchanger;however,thereductionofextracellularK+ortheadditionofSchering28080causedasignificantreductionofNa+-independentpHirecovery,confirmingthepresenceofaH+-K+-ATPa...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第2期Tlxactsasaproangiogenicswitchbyregulatingextracellularassemblyoffibronectinmatricesinretinalastrocytes
...responsetothemicroenvironmentaloxygenconcentration.Whilethemolecularmechanismscontrollingtheangiogenicprocessesarevastlyheterogeneous,dependingonthesurroundingcelltypes(4),hypoxia-induciblefactors(HIFs)actastheprimarymolecularswitchestotheproangiogenicstateinmanyinstances(5,6).Underhypoxicconditions...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第2期第五節 器官循環
...s.CircRes1984;55:565-574 12.SieglPKS.Overviewofcardiacinotropicmechanisms.JCardiovascPharmacol1986;8(suppl9):S1-S10 13.CarafoliEIntracellularcalciumhomeostasis.AnnRevBiochem1987;56:395-433 14.BrownJHetal.Phosphoinositide-generatedsecondmessengersincardiacsignaltransduction.TrendsinCar...
醫源資料庫;醫源圖書館;教材類;生理學ErtiprotafibImprovesGlycemicControlandLowersLipidsviaMultipleMechanisms
...dlevels.TheseresultssuggestedthatthistherapeuticactivitymightinvolvemechanismsinadditiontoPTP1binhibition.Inthisstudy,wedemonstratethatertiprotafibactivatesperoxisomeproliferator-activatedreceptor(PPAR)andPPARatconcentrationscomparablewiththoseofknownagonistsoftheseregulators.Furthermore,itisabletod...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第1期BiomechanicalDeterminantsofAbdominalAorticAneurysmRupture
...urgh,PA15219.E-mailvorpda@upmc.eduSeriesEditor:RobertW.ThompsonRedoxMechanismsinBloodVesselsATVBinFocusPreviousBriefReviewsinthisSeries:?PowellJT,BradyAR.Detection,Management,andprospectsforthemedicaltreatmentofsmallabdominalaorticanesrysms.2004;24:241–246.?DaughertyA,CassisLA.Mousemodelsofabdomin...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第8期StatinsandBloodCoagulation
...wever,areonlypoorlycorrelatedwithcholesterollowering,suggestingothermechanismsareatplay.Mevalonate,theproductofHMG-CoAreductase,istheprecursorofnotonlycholesterolbutalsoisoprenoidcompoundsthatpermittheattachmentofsignalingproteinstothecellmembrane.3,4Abundantexperimentalandclinicalevidenceinthisrapi...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第2期LuminalflowinduceseNOSactivationandtranslocationintheratthickascendinglimb.II.RoleofPI3-kinaseandHsp9
...neNOStranslocation,ithasbeenshownthatHsp90regulateseNOSactivitybytwomechanisms.First,Hsp90mayactasascaffoldingprotein,increasingtheinteractionofeNOSwithAkt(13),and,second,Hsp90maydirectlymodifyeNOSenzymaticactivitybychangingitsstructureviadirectbinding(48).WhiletheexactmechanismbywhichHsp90influence...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第8期