ReductionofAtheroscleroticPlaquesbyLysosomalAcidLipaseSupplementation
...ses.29,30LALcontributestocholesterolandfattyacidhomeostasisbyseveralmechanisms.OncecholesterylestersarecleavedbyLAL,freecholesterolexitsthelysosomeandparticipatesinthemodulationofcholesterolandfattyacidmetabolismviathesterolregulatoryelement-bindingprotein(SREBP)system.31–34Freecholesterol,aproduc...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第1期PlateletInhibitionbyInsulinIsAbsentinType2DiabetesMellitus
...iate2pathwaysthatdirectlyinterferewithplateletactivatingorinhibitingmechanisms.First,thereistheactivationoftheG-proteinsubunitGi,whichinhibitsadenylylcyclaseandtherebyformationoftheplateletinhibitorcAMP.8Thispropertyisparticularlyevidentaftertreatmentwithprostacyclin,9andalsointheabsenceofcAMPelevat...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第2期InVivoActionsofAngiopoietinsonQuiescentandRemodelingBloodandLymphaticVesselsinMouseAirwaysandSkin
...Ang1,Ang2,Ang3,andAng4,hasprovidedinsightintothemolecularandcellularmechanismsofbloodvesselformationandvascularprotection.1-4Ang3andAng4wereidentifiedasinterspeciesorthologsbetweenmouseandhuman.5Allangiopoietinsaresecretedproteins,andtheybindtotheendothelialcelltyrosinekinasereceptor,Tie2,whichisfou...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第3期PorkwithahighcontentofpolyunsaturatedfattyacidslowersLDLcholesterolinwomen
...todecreasetotalcholesterol,LDLcholesterol,andHDLcholesterolbyseveralmechanisms,includingdecreasedLDLapolipoproteinBproductionratesandincreasedHDLapolipoproteinA-Icatabolisminmonkeys(49,50).Inaddition,PUFAsarereportedtoincreaseLDLapolipoproteinBcatabolism(49).PUFAsmayalsodecreasetotalandLDLcholestero...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2001年74卷第2期Dietaryfats,carbohydrate,andprogressionofcoronaryatherosclerosisinpostmenopausalwomen
...akeandatheroscleroticprogressionarenotable.Arethereplausiblebiologicmechanismsforsuchaneffect?Incontrastwiththefindingsofexperimentalstudies(20,21,47-50),saturatedfatintakewasnotassociatedwithLDLconcentrationsinourstudy.WomenwithlowersaturatedfatintakeatenrollmentmayhavepreviouslyhadhigherLDL-choles...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2004年80卷第5期Theintestineanditsmicrofloraarepartnersfortheprotectionofthehost:reportontheDanoneSymposium“TheIntelligentIntestine,“heldinParis,June
...rierandthemainsiteofinteractionwithforeignsubstancesandexogenousmicroorganisms.Itisacomplexphysicochemicalstructureconsistingofamucouslayerlinkedtocellularandstromalcomponentsthatparticipateinthedefenseofthehostthroughmucosalbloodflow,mucosalsecretions,epithelialcellfunctionals,surfacehydrophobicity...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2003年78卷第4期HighPrevalenceofCirculatingCD4+CD28–T-CellsinPatientsWithSmallAbdominalAorticAneurysms
...oassessthepossibleroleofproinflammatoryCD28–Tcellsinabdominalaorticaneurysms(AAAs).Animalstudiesandhumantissuestudiessuggestaroleforinterferon(IFN)-–producingTcellsinthedevelopmentandprogressionofAAAs.MethodsandResults—Fluorescence-activatedcellssorteranalysisofperipheralbloodsamplesandmeasure...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第7期HumanLeukocyteAntigenandCytokineGeneVariantsasPredictorsofRecurrentChlamydiatrachomatisInfectioninHigh-RiskAdolescents
...ations[2124].ClassificationofT-helpertype1(TH1)andTH2cytokinegenepolymorphisms.Apanelof16commonsingle-nucleotidepolymorphisms(SNPs)(table1)from7genes(interleukin2[IL2],IL4,IL4R,IL6,IL10,IL12B,andtumornecrosisfactor[TNF])representingbothTH1andTH2pathwaysinthecytokinenetworkweretypedbyPCRwithsequence-...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第7期GeneticandEnvironmentalDeterminantsofFibrinStructureandFunction
...ls.25Thedifferencesarenotattributabletoclassicriskfactorsorcommonpolymorphisms.Insubjectswithtype1diabetesmellitus,thefibrinclotislessporousbutwithnodifferenceinfibermass-to-lengthratio.20Thisisindependentoffibrinogenconcentration.GeneticandEnvironmentalFactorsAlteringFibrinStructureBecausefibrinstr...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第9期UseofShell-VialCellCultureAssayforIsolationofBacteriafromClinicalSpecimens:13YearsofExperience
...edourexperienceofusingtheshell-vialcultureassayfortheisolationofmicroorganismsfromvariousclinicalsamples.Overa13-yearperiod,wehaveisolated580bacterialstrains(5%)from11,083clinicalsamplestested.Overthesameperiod,285isolatesofrickettsiae,bartonellae,orCoxiellaburnetiiwereculturedfromatotalof7,102sampl...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期