ActivityandSubcellularTraffickingoftheSodium-CoupledCholineTransporterCHTIsRegulatedAcutelybyPeroxynitrite
...levelsofHC-3bindingandbiotinylatedCHTattheplasmamembrane.Itisnoteworthythatshort-termexposureofcellstoSIN-1acceleratedtherateofinternalizationofCHTfromtheplasmamembrane,butitdidnotalterreturnofCHTbacktothecellsurface.SIN-1didnotdisruptcellmembraneintegrityorcausecelldeath.Thus,theinhibitoryeffectofS...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期研究發現志賀菌重寫宿主細胞的轉錄反應
...,組蛋白修飾是精調基因表達的重要手段。福氏志賀菌(Shigellaflexneri)中具有雙重身份的特異性磷酸酶OspF,通過誘導細胞表觀遺傳上的修飾,從而改變了宿主的炎性轉錄反應。該研究成果發表在《NatureImmunology》雜誌上。致病性...
醫藥經濟;生物技術;技術要聞Miningyeastinsilicounearthsagoldennuggetformitochondrialbiology
...chondrialgenome.Accordingtolow-resolutionelectronmicrographs,complexIisanL-shapedheteromultimer(1).Arelativelyhydrophilicmatrixarmextendsintotheinteriorofthemitochondriaandisconnectedtoamorehydrophobicsegmentlocatedwithintheinnermitochondrialmembrane(4)(Figure1).Theprecisemolecularmechanismsthatcoup...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期色譜反吹法快速檢測天然氣中硫化物
...2B),定量管中樣品進入色譜柱得到分離,當H2S,COS,CH3SH,(CH3)2S,峯出完後轉動八通閥到位置A色譜柱反向沖洗將剩餘的組分做一個峯吹出見圖3。此時柱溫爲60℃。反吹時間可以任意設置,可視需要設在H2S後,也可在(CH3)2S...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文Sphingosine-1-PhosphateAnalogueFTY720CausesLymphocyteRedistributionandHypercholesterolemiainApoE-DeficientMice
【摘要】Objective—Residentimmunecellsareahallmarkofatheroscleroticlesions.ThesphingolipidanaloguedrugFTY720mediatesretraffickingofimmunecellsandinhibitstheirhomingtoinflammatorysites.WehaveevaluatedtheeffectofFTY720onatherogenesisandlipidmetabolism.MethodsandResults—ApoE–/&ndas...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第11期Stereochemicalassignment,antiinflammatoryproperties,andreceptorfortheomega-3lipidmediatorresolvinE1
...DepartmentofAnesthesiology,Perioperative,andPainMedicine,BrighamandWomen‘sHospitalandHarvardMedicalSchool,Boston,MA021152ImmunobiologySection,LaboratoryofParasiticDiseases,NationalInstituteofAllergyandInfectiousDiseases,NationalInstitutesofHealth,Bethesda,MD208923DepartmentofChemistryandLokerHydro...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第5期第四節 G蛋白和磷脂酶C
...細胞極化(polarization)和抗原的提呈。某些信號蛋白通過SH-3功能區將酪氨酸激酶途徑同一些由小G蛋白所控制的途徑連接起來,如Rho(與Ras有30%同源性)調節胞漿中微絲上肌動蛋白的聚合或解離,從而影響細胞形態。這一事實解...
醫源資料庫;醫源圖書館;教材類;細胞和分子免疫學Vascularendothelialgrowthfactorisanimportantdeterminantofsepsismorbidityandmortality
...inflammatoryandcoagulationpathways.Animprovedunderstandingofthesemechanismsshouldprovideanimportantfoundationfordevelopingnoveltherapies.Inthisstudy,weshowthatsepsisisassociatedwithatime-dependentincreaseincirculatinglevelsofvascularendothelialgrowthfactor(VEGF)andplacentalgrowthfactor(PlGF)inanimal...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第6期TheprevalenceofglaucomainBangladesh:apopulationbasedsurveyinDhakadivision
1MAIInstituteofOphthalmologyandIslamiaEyeHospital,Farmgate,Dhaka,Bangladesh2DivisionofEpidemiology,InstituteofOphthalmology,BathStreet,London,UK3GlaucomaResearchUnit,MoorfieldsEyeHospital,CityRoad,London,UK4BangladeshEyeCareSociety,Lalmatia,Dhaka,Bangladesh5ClinicalResearchUnit,LondonSchoolofHygiene...
醫源資料庫;在線期刊;英國眼科學雜誌;2004年第88卷第12期中醫藥法歷30載破冰上市藥企先覺佈局產業鏈
...,比如雲南白藥(000538.SZ)、同仁堂(600085.SZ)、片仔癀(600436.SH);中藥現代化龍頭企業有望從規範化經營、規模化發展的趨勢中持續受益,比如天士力(600535.SH)、康緣藥業(600557.SH)、以嶺藥業(002603.SZ)。 近期諸多中醫藥公司的動作...
醫藥經濟;生物技術;技術要聞