DetectionofablaSHVExtended-Spectrum-LactamaseinSalmonellaentericaSerovarNewportMDR-AmpC
...ofS.entericaserovarNewportisolatesweredeterminedusingaSensititreCMV2ECOFCompanion/EquineMICveterinaryplate(TrekDiagnostics,Cleveland,Ohio),andtheinterpretationofbreakpointswasasdeterminedbythemanufactureraccordingtoCLSI(formerlyNCCLS)guidelines,whenavailable(14-16).SerovarNewportstrainSRC0307-213,is...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第11期異種輸血對大鼠內臟功能的影響
...【摘要】 目的 觀測靜脈輸注人、豬、豚鼠全血對大鼠存活及內臟功能的影響,爲今後研究供體特異性輸血誘導異種免疫耐受奠定基礎。方法 大鼠陰莖背靜脈輸注人、豬、豚鼠全血,每隻大鼠每天1ml。輸人血的45只大鼠平均...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學GlycogenSynthaseKinase3RegulatesN-Methyl-D-aspartateReceptorChannelTraffickingandFunctioninCorticalNeurons
...underlyingtheactionsofGSK-3remaintobeidentified.Inthisstudy,weexaminedtheimpactofGSK-3ontheN-methyl-D-aspartate(NMDA)receptorchannel,acentralplayerinvolvedincognitiveandemotionalprocesses.WefoundthatapplicationofvariousstructurallydifferentGSK-3inhibitorscausedalong-lastingreductionofNMDAreceptor-me...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第7期AMajorSpeciesofMousee?opioidReceptormRNAandItsPromoter-DependentFunctionalPolyadenylationSignal
DepartmentofPharmacology,UniversityofMinnesotaMedicalSchool,Minneapolis,MinnesotaAbstractThepharmacologicaleffectsofopioiddrugsaremediatedmainlybythee?opioidreceptor(MOR),whichisencodedbyanmRNAtranscriptnamedMOR1.AlthoughseveralMORmRNAsplicevariantshavebeenreported,theirbiologicalrelevancehasbeendeb...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第2期卵巢局部調節因子在排卵機制中的研究進展
...泛水解酶活性。其前體纖溶酶原可在纖溶酶激活因子(tPA,uPA)作用下在其Arg560-Val561處斷裂形成由二硫鍵連接的雙鏈分子纖溶酶。纖溶酶主要是通過打開纖蛋白分子的Arg-x和Lys-x鍵而降解ECM[11]。纖溶酶原激活因子(PA)有兩種...
合作平臺;在線期刊;中華現代中西醫雜誌;2004年第2卷第10期;綜述JBacteriol:綠膿桿菌最新研究進展兩則
...號分子。發現影響綠膿桿菌毒力的兩個I型信號肽酶LepB和PA1303近日,國際著名雜誌《細菌學雜誌》JournalofBacteriology上刊登了倫敦皇后瑪麗大學的研究者的最新研究成果“PseudomonasaeruginosapossessestwoputativeType1signalpeptidases,LepBandPA1303...
醫藥經濟;生物技術;技術要聞ExtentofEarlyIschemicChangesonComputedTomography(CT)BeforeThrombolysis
theDepartmentofClinicalNeurosciences(I.D.,M.D.H.,S.B.C.,A.M.D.),CalgaryStrokeProgram,UniversityofCalgary,Alberta,CanadaDepartmentofNeuroradiology(I.D.,O.W.,R.v.K.),UniversityofTechnologyDresden,Dresden,GermanyDepartmentsofCommunityHealthSciencesandMedicine(M.D.H.),UniversityofCalgary,Alberta,CanadaI...
醫源資料庫;在線期刊;中風學雜誌;2006年第37卷第4期FailureofCefepimeTherapyinTreatmentofKlebsiellapneumoniaeBacteremia
CenterforResearchinAntiinfectivesandBiotechnology,DepartmentofMedicalMicrobiologyandImmunology,CreightonUniversitySchoolofMedicine,2500CaliforniaPlaza,Omaha,Nebraska68178DepartmentsofPharmacologyPathology,TheUniversityofTexasHealthScienceCenter,SanAntonio,Texas78229ABSTRACTAcaseoffailureofcefepimetr...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第9期EthanolModulatestheInteractionoftheEndogenousNeurosteroidAllopregnanolonewiththe122LGABAAReceptor
...senceofthecompetitivesteroidantagonist(3,5)-17-phenylandrost-16-en-3-ol(17-PA)diminishesthepositiveinteractionbetweenethanoland35PontheGABAAreceptor.Together,thefindingssuggestthatsteroidinteractionswiththeclassicsteroidbindingsiteunderlietheeffectseeninthepresenceofethanol,andthatethanolactsbyincre...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第2期專訪邱小波:突破桎梏取得創新性成就
...。如不及時修復DNA損傷,細胞可能會發生癌變,甚至危及存活。爲了有效地修復損傷的DNA,組蛋白必需從核小體中釋放出來,從而爲DNA修復蛋白順利到達工作位點提供足夠的空間保障。所以,此時的組蛋白降解可確保損傷的DNA被...
醫藥經濟;生物技術;技術要聞