HMG-CoAreductaseinhibitorsimvastatinmitigatesVEGF-inducedinside-outsignalingtoextracellularmatrixbypreventingRhoAactivation
...meA(HMG-CoA)reductaseinhibitorsexertmodulatoryeffectsonanumberofcellsignalingcascadesbypreventingthesynthesisofvariousisoprenoidsderivedfromthemevalonatepathway.Inthepresentstudy,wedescribeanovelpleiotropiceffectofHMG-CoAreductaseinhibitors,alsocommonlyknownasstatins,onvascularendothelialgrowthfacto...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第11期Cyclooxygenases,microsomalprostaglandinEsynthase-1,andcardiovascularfunction
...sylvania,USA.2DepartmentsofPhysiologyandBiochemistry,Queen’sUniversity,Kingston,Ontario,Canada.AbstractWeinvestigatedthemechanismsbywhichinhibitorsofprostaglandinG/Hsynthase-2(PGHS-2;knowncolloquiallyasCOX-2)increasetheincidenceofmyocardialinfarctionandstroke.Theseinhibitorsarebelievedtoexertbotht...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第5期VascularEndothelialGrowthFactorIsInducedbytheInflammatoryCytokinesInterleukin-6andOncostatinMinHumanAdiposeTissueInVitroandinMurineAdip
...】Objectives-Itisbelievedthatadiposetissueactsasanendocrineorganbyproducinginflammatorymediatorsandtherebycontributestotheincreasedcardiovascularriskseeninobesity.Alinkbetweenadiposetissuemassandangiogenesishasbeensuggested.Vascularendothelialgrowthfactor(VEGF)seemstobeimplicatedinthisprocess.Membe...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第7期IL-1receptor–associatedkinaseMisacentralregulatorofosteoclastdifferentiationandactivation
...omthefusionofmacrophagesandtheyplayacentralroleinbonedevelopmentandremodelingviatheresorptionofbone.Therefore,osteoclastsareimportantmediatorsofbonelossthatleads,forexample,toosteoporosis.Interleukin(IL)-1receptor(IL-1R)–associatedkinaseM(IRAK-M)isonlyexpressedincellsofthemyeloidlineageanditinhibi...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第7期氣相色譜電子捕獲法測定人體血漿中尼索地平的濃度
...在鹼性條件下用乙醚-環己烷(1∶1)提取。結果:在0.1~30ng.mL-1濃度範圍內峯面積比與濃度呈良好的線性關係,r=0.9997。人血漿中尼索地平的最低檢出濃度爲50pg.mL-1。高、中、低3種濃度的平均回收率爲91.92%~97.89%,日內和日間精密...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文Roleofinterleukin-1?inthepathogenesisofdiabeticretinopathy
...TheroleofIL-1?intheacceleratedendothelialcelllosswasdeterminedbyinvestigatingtheeffectofhumanrecombinantIL-1?ontheirapoptosisinnormalandhighglucoseconditions,andwasconfirmedusinginterleukin-1receptorantagonist(IL-1ra).Results:HighglucoseincreasedIL-1?expressionby60%comparedwithcellsincubatedin5mMglu...
醫源資料庫;在線期刊;英國眼科學雜誌;2004年第88卷第10期扎來普隆舌下噴霧劑在比格犬體內的相對生物利用度
...犬;反相高效液相色譜法RelativebioavailabilityofzaleplonbysublingualsprayinhealthBeagledogWANGHui-tao,GUOYan-fang,GAOYong-liang,etal.DepartmentofPharmacy,ShanxiMedicalUniversity,Taiyuan030001,China【Abstract】ObjectiveTostudytherelativebioavailabilityofzaleplonbysublingualsprayinhealthyb...
醫源資料庫;在線期刊;中華現代中醫學雜誌;2008年第4卷第2期MRI及動態增強掃描對前列腺癌的診斷價值
...帶單發病竈14例,佔全部病例的11.3%;外周帶單側或雙側瀰漫病竈29例,佔全部病例的22.7%;由外周帶侵犯中央腺體40例,佔全部病例的34%;中央腺體病竈8例,佔全部病例的6.7%;病竈瀰漫不能判斷起源者29例,佔全部病例的25...
醫源資料庫;在線期刊;中華現代影像學雜誌;2008年第5卷第6期第二節 甲狀腺功能紊亂的臨牀生化
...功能異常升高產生的內分泌病。病因複雜多樣,約75%爲瀰漫性甲狀腺腫伴甲亢,即Graves病,該病現傾向於爲一種自身免疫病;另有約15%爲腺瘤樣甲狀腺腫伴甲亢;近10%爲急性或亞急性甲狀腺炎;垂體腫瘤、濾泡性甲狀腺癌性...
醫源資料庫;醫源圖書館;教材類;臨牀生物化學利培酮和氟哌啶醇對精神分裂症患者超氧化物歧化酶及催乳素影響的臨牀對照研究
...0例)、氟哌啶醇組(33例)患者的基線SOD濃度[(794±126)ng/mgHb,(750±101)mg/mgHb]均明顯高於正常對照組[(483±110)ng/mgHb],而PRL濃度[(6±7)μs/L,(6±8)μg/L]均明顯低於正常對照組[(18±12)μg/L],差異均有統計學意...
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