Regulationofphosphatidylinositol3–kinasebypolyisoprenylphosphatesinneutrophil-mediatedtissueinjury
...coupledphosphoinositide3-kinasegammaininflammation.Science.287:1049–1053.Yum,H.K.,J.Arcaroli,J.Kupfner,R.Shenkar,J.M.Penninger,T.Sasaki,K.Y.Yang,J.S.Park,andE.Abraham.2001.Involvementofphosphoinositide3-kinasesinneutrophilactivationandthedevelopmentofacutelunginjury.J.Immunol.167:6601–6608.Serha...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期AutoantibodiesmakeaU-turn:thetollhypothesisforautoantibodyspecificity
...yawaited.InthestudybyVollmeretal.(2),themajorconsequenceofTLR7/8activationbyU-richRNAswastheproductionofIFN-,acytokinelongknowntobeelevatedinpatientswithSLE.AlthoughthelowIFNresponseinTLR7–/–micesuggestsadominantroleforthisreceptorinresponsetoU1RNA,itisrelevanttonotethatbothviralandmammaliannucl...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第11期全新的疫苗延長神經膠母細胞瘤患者存活時間
...神經腫瘤學主任、同時也是該臨牀研究主要研究者的JohnS.Yu醫師表示,如果我們可以改善疫苗的免疫反應率,我們同樣能預期將有臨牀上的好處,這致使我們能將我們的疫苗以更即時的方式進行微調。 樹突疫苗科技特定...
行業資訊;臨牀快報;神經科Evidencefordiscretestagesofhumannaturalkillercelldifferentiationinvivo
...playasimilargradualup-regulationofCD56asthatseenonCD34(+)CD117(+)HPCsandtheyuniformlycoexpressthepan-NKcellreceptorCD161(Fig.1D).Thus,withinbothCD34(+)andCD34(–)mononuclearfractionsofhumanSLT,CD117expressionishighlyassociatedwiththeNKcelllineage.Giventhesecollectivedata,wehypothesizedthathumanNKce...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期PropertiesofNovelInternationalDrug-ResistantPneumococcalClonesIdentifiedinDay-CareCentersofLisbon,Portugal
...ibilitytesting,serotyping,andpulsed-fieldgelelectrophoresis(PFGE)arecommonlyusedforlocalsurveillanceofpathogensaspneumococci.Forglobalepidemiology,multilocussequencetyping(MLST)(10)hasbecomethemostvaluabletool(16).Inthisstudy61DRPnstrainswerecharacterizedbyMLSTinordertoidentifyandrelatetheirgeneticb...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第9期Nutritionalstimulationofcholecystokininreceptorsinhibitsinflammationviathevagusnerve
...eennutritionandtheimmuneresponseandhaswidespreadimplications.Itwaspreviouslyunrecognizedthatnutrition-inducedneuro-endocrinesignalssuchasCCKmodulatetheimmuneresponsebywayoftheefferentvagusnerve.Fromateleologicalpointofviewitisfunctionalthatastateofimmune-hyporesponsivenessiscreatedduringfeeding.Inth...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第8期RoleofHMGB1inapoptosis-mediatedsepsislethality
...hemechanismlinkingorganfailureanddeathtoapoptosisinseveresepsiswaspreviouslyunknown.Recentevidenceindicatesthathighmobilitygroupbox1(HMGB1),aubiquitousnuclearprotein,isacytokinethatmediatesorgandamageinseveresepsis(9,10).HighlevelsofHMGB1accumulateinanimalsandhumanswithseveresepsis(9,10).Administrat...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第7期SimultaneousDetectionofHepatitisCVirus(HCV)CoreAntigenandAnti-HCVAntibodiesImprovestheEarlyDetectionofHCVInfection
...14,15,21,30,39).Insomecountries,anassayforthedetectionofHCVcoreantigen(Ag)byuseoftheenzymeimmunoassay(EIA)technologyhasbeenchosenasanalternativetoNATfortheearlydiagnosisofinfection(1,8,25,38).Inaddition,someauthorsemphasizedtheclinicaladvantageofHCVcoreAgquantificationasadirectmarkerofviralreplicati...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第8期嵌合體防齲疫苗的研究進展
...sucrosebinding,SB),C端爲葡聚糖結合區(glucanbinding,GB)[8]。Yu等[9]用基因重組方法獲得了AgⅠ/Ⅱ的A區與GTF的SB區或GB區嵌合的抗原蛋白,方法爲:經PCR分別獲得編碼GTF-SB區、GTF-GB區和AgⅠ/Ⅱa區的基因,分別將編碼GTF-GB區段和GTF-SB區...
合作平臺;醫學論文;臨牀醫學與專科論文;口腔醫學CountrywideSpreadofCommunity-andHospital-AcquiredExtended-Spectrum-Lactamase(CTX-M-15)-ProducingEnterobacteriaceaeinLebanon
...reportofanSHV-5a-producingC.freundii.INTRODUCTION-Lactamantibioticsarewidelyusedinthetreatmentofbacterialinfections.However,theproductionofextended-spectrum-lactamases(ESBLs),oneoftheresistancemechanismsencounteredinEnterobacteriaceae,hasbeenassociatedwithseveraltreatmentfailures.Indeed,ESBLsarecapa...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期