PharmacogeneticDifferencesinResponsetoAlbuterolbetweenPuertoRicansandMexicanswithAsthma
...tionstothecontemporaryLatinogenepoolmakeeachLatinoethnicgroupgeneticallyunique(2).AccordingtoU.S.vitalstatistics,asthmaprevalence,morbidity,andmortalityarethehighestamongPuertoRicansandthelowestamongMexicansforatotalofafourfolddifferenceinasthmaburdenbetweenthesetwoethnicgroups(3,4).Althoughthereare...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第3期AssociationBetween5-LipoxygenaseExpressionandPlaqueInstabilityinHumans
...ggestedbyrecentstudies.However,arolefor5-LOasamodulatorofatheroscleroticplaqueinstabilityhasnotbeenpreviouslyreportedinhumans.Thus,theaimsofthisstudywastoanalyzetheexpressionof5-LOinhumancarotidplaquesandtoinvestigatethemechanismbywhichthisenzymecouldleadtoplaqueinstabilityandrupture.MethodsandResul...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第8期Mildrenalischemia-reperfusionreduceschargeandsizeselectivityoftheglomerularbarrier
...ularbarrierincooled(8°C)isolatedperfusedkidneys(cIPK).Renalbloodflowwasquicklyrestored,whereastheglomerularfiltrationrateremainedhalved30minafterIRI.TubularcellactivitywasintactasjudgedfromtheunaffectedCr-EDTAU/Pconcentrationratio.Invivo,thefractionalclearance()foralbuminincreased16times.Inratss...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第6期EffectofPeroxisomeProliferator–ActivatedReceptor-and-ActivatorsonVascularRemodelinginEndothelin-DependentHypertension
...dofOrmsbeeandRyan.13Inbrief,maleSprague-Dawleyrats(CharlesRiver,StConstant,Québec,Canada)weighing225gwereunilaterallynephrectomizedundersodiumpentobarbitalanesthesia(40mg/kg).SiliconerubberimpregnatedwithDOCA(200mgperrat,n=6)wasimplantedsubcutaneously,andratswereoffered1%salinetodrink.Controlrats(U...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2003年第23卷第1期MolecularSignaturesDeterminingCoronaryArteryandSaphenousVeinSmoothMuscleCellPhenotypes
...s.6,7However,themolecularfeaturesthatdeterminethedifferentSMCsubtypesanduniquefunctionalresponsesarestillpoorlyelucidated.Inthisstudy,weusedmicroarraygeneexpressionprofilingtoidentifytheuniquemolecularsignaturesthatdistinguishhumanvascularSMCsubtypesfromsaphenousvein(SVSM)andcoronaryartery(CASM),and...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第5期PrognosticUtilityofLipoprotein-AssociatedPhospholipaseA2forCardiovascularOutcomesinPatientsWithStableCoronaryArteryDisease
...atincludedhs-CRP.Afteradjustmentforbaselinecharacteristics,patientsinhigherquartilesofLp-PLA2remainedatsignificantlygreaterriskforthecompositeofcardiovasculardeath,MI,coronaryrevascularization,UA,orstroke(P0.001fortrend,adjHR1.41,95%CI1.17to1.70,forpatientsin4thversus1stquartile).Theassociationwasco...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第11期RegulationofrenalNaPi-2expressionandtubularphosphatereabsorptionbygrowthhormoneinthejuvenilerat
...cedgrowthratewasusedasanindicatorofthesuppressionofpulsatileGHrelease.Theacquisitionofthedataforthethreeexperimentalgroupswasperformedinparallel.Thedatafortheadultandjuvenileratshavebeenpreviouslypublished(37).ThismanuscriptincludespartsofthepreviouslypublisheddataascontrolstocontrasttheeffectsofGHs...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第7期EnhancementofAntimycobacterialActivityofMacrophagesbyStabilizationofInnerMitochondrialMembranePotential
...ociatedwithkillingofintracellularmycobacteriaandmightalsobenefitthehostbysequesteringbacilliinapoptoticbodiesforsubsequentexpediteduptakebyphagocytes[36].Thiswouldpreventtheextracellularspreadofinfectionandprotectsurroundingtissuesfromtheharmfuleffectsofcellularnecrosis.Macrophagesinfectedwithmycoba...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第8期Proapoptotic,Antimigratory,Antiproliferative,andAntiangiogenicEffectsofCommercialC-ReactiveProteinonVariousHumanEndothelialCellTypesInVitro
...alCRP,dialyzedcommercialCRP(dCRP)toremoveazide,andsodiumazide(NaN3)aloneatequivalentconcentrationstotheundialyzedpreparationweretestedatvaryingconcentrationsonhumanumbilicalveinendothelialcells(HUVEC),circulatingendothelialoutgrowthcells(EOC),andendothelialprogenitorcells(EPC)invitro.CRPandNaN3alone...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第7期海馬區神經幹細胞分化增殖及其對中樞系統疾病的治療
...力,這些新形成的神經細胞參與海馬依賴性的記憶過程。Qu等[11]把神經球狀態的未分化人NSC(HNSCs)移植到青年和老年大鼠側腦室,30d後,移植的HNSCs分化成神經細胞和星形膠質細胞,這些細胞以非常有序的模式遷移到海馬和...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2006年第6卷第5期