InteractionsofTGF-dependentandmyogenicoscillationsintubularpressure
...llationsindicatesthatestimatesoftherelativecontributionofeachofthesemechanismsinrenalautoregulationneedtoaccountforthisinteraction.ThemagnitudeofmyogenicoscillationswasconsiderablysmallerintheSFPmeasuredfromspontaneouslyhypertensiverats(SHR,n=13);consequently,nonlinearinteractionswerenotobservedwith...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第2期OverexpressionofHyaluronanintheTunicaMediaPromotestheDevelopmentofAtherosclerosis
...inatedaccumulationofHAacceleratestheatherogenicprocessinvivo.Severalmechanismsarelikelytoplayaroleintheaugmentedatherogenesis.First,arecentreporthasdescribedanattenuateddevelopmentofatherosclerosisinmicegeneticallyengineeredtolackCD44.32BecauseHAistheprincipalligandforCD44,theobservationiscompatible...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第3期GenderDifferencesinExperimentalAorticAneurysmFormation
...uctionandactivity.IngroupII,M-to-Maortictransplantsuniformlydevelopedaneurysmsafterelastaseperfusion,whereasF-to-Faortictransplantsremainedresistanttoaneurysmformation.FaortastransplantedintoMrecipients,however,lostaneurysmresistance.IngroupIII,estradiol-treatedratsdemonstratedsmalleraneurysmsandles...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第11期Keyroleofpoly--dl-glutamicacidinimmuneevasionandvirulenceofStaphylococcusepidermidis
...gtobiofilmformationandfrequentantibioticresistance.However,virulencemechanismsoftheseimportantopportunisticpathogenshaveremainedpoorlycharacterized.HerewedemonstratethatS.epidermidissecretespoly--DL-glutamicacid(PGA)tofacilitategrowthandsurvivalinthehumanhost.Importantly,PGAefficientlyshelteredS.epi...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期AssociationofOAZ1GenePolymorphismsWithSubclinicalandClinicalVascularEvents
...seantizyme1(OAZ1).Therefore,wesoughtforassociationbetweenOAZ1genepolymorphismsandvariousoutcomesinvolvingVSMCproliferation.MethodsandResults—SystematicscreeningoftheOAZ1geneenabledtodetect21variants.Theimpactof4selectedtagpolymorphisms(+849C/T,+851G/T,+1804G/A,and+2222A/G)wasevaluatedin3indepe...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第10期PathogenesisofObstructiveandCentralSleepApnea
...rderedbreathing(1,2).Wehavealsosteadilyimprovedourunderstandingofthemechanismsleadingtothisdisorderedbreathing,withmostsuchworkbeingfocusedontwoprincipalareas:(1)themechanismsthatinfluenceupperairwaypatencyawakeandasleepand(2)ventilatorycontrolstabilityduringsleep(3,4).Althoughproblemswithmaintenanc...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第12期In-DepthHaplotypeAnalysisofABCA1GenePolymorphismsinRelationtoPlasmaApoA1LevelsandMyocardialInfarction
...ctedtoplayakeyroleinlipidhomeostasisandatherosclerosis.Twenty-sixpolymorphismsoftheABCA1geneweregenotypedandtestedforassociationwithplasmalevelsofApoA1andmyocardialinfarction(MI)intheECTIMstudy.MethodsandResults—Inadditiontosingle-locusanalysis,asystematicexplorationofallpossiblehaplotypeeffectswa...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第4期CharacterizationofammoniatransportbythekidneyRhglycoproteinsRhBGandRhCG
...familyofproteins,towhichRhBGandRhCGbelong,areexpressedinabroadrangeoforganisms,frombacteriaandyeasttoplantsandmammals.ThestructureofE.coliAmtBhasrecentlybeensolvedbytwogroupsusingX-raycrystallography(17,42).ThestructurerevealsthatthebacterialproteintransportsunchargedNH3viaauniquemechanism.AmtBconta...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第3期ClinicalEvaluationoftheDiversiLabMicrobialTypingSystemUsingRepetitive-Sequence-BasedPCRforCharacterizationofStaphylococcusaureusStrains
...robiologylaboratoriesareoftenaskedtodeterminetherelatednessofgroupsoforganisms.Thisrequirestheuseofamolecularstraintypingsystemwithcertainperformancecharacteristics(15).Foreachisolate,thesystemshouldprovideaninterpretableresult,preferablybasedonobjectivecriteria.Resultsshouldbereproduciblefromdaytod...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第3期EstrogenReducesAngiotensinII–InducedNitricOxideSynthaseandNAD(P)HOxidaseExpressioninEndothelialCells
...butabletoscavengingeffectsofsuperoxideanion).Thus,thesepathwaysmaybemechanismsformodulatingAII-mediatedvasoconstriction.AIImayalsoincreaseoxidativestressintheshorttermbyimmediateactivationofNAD(P)Hoxidasetoformsuperoxideanion.36–38Indeed,Zhangetal39demonstratedthatAIIinducesimmediatereleaseofsuper...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2003年第23卷第1期