Renaloxidativevulnerabilityduetochangesinmitochondrial-glutathioneandenergyhomeostasisinaratmodelofcalciumoxalateurolithiasis
...ptmitochondrialfunctionbyincreasingproductionofreactiveoxygenintermediates(ROI),decreasingmitochondrialmembranepotential,andincreasingmitochondrialpermeability(16).ROIgeneratedbyredox-activeandcell-compartmentalizedprocessesareinvolvedinvariousdiseasesincludingcancer(8).ROImediatedamageviamodificati...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第10期Noninvasiveimagingofpancreaticinflammationanditsreversalintype1diabetes
...slatertoprovideinformationaboutmicrovascularpermeability.Aregionofinterest(ROI)wasdrawnaroundthepancreas(Figure1),andtheT2valueoftheorganwascalculated,withthepresenceofnanoparticleswithinanorgandecreasingitsT2value.Figure1Mappingorgan-specificT2values.Multiple-slice,multiple-echoT2-weightedspin-echo...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第9期AngiotensinII-inducedcalciumsignalingintheafferentarteriolefromratswithtwo-kidney,one-cliphypertension
...oimageswereanalyzedwithImageMaster1.49SoftwarefromPTI,andregionsofinterest(ROI)onthevesselsweredefinedwiththesoftwaretoaccuratelycollectthefura-2fluorescencefromtheafferentsegments.TheROIswerecreatedataminimumdistanceof20µmfromthebranchingpointsbetweenAAandILA.Backgroundfluorescencefromaregion...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第7期Distinctorgan-specificmetastaticpotentialofindividualbreastcancercellsandprimarytumors
...rementofphotonflux(measuredinphotons/s/cm2/steradian)witharegionofinterest(ROI)drawnaroundthebioluminescencesignaltobemeasured.Forbonemetastasis,anROIwasdrawnaroundthemajorbioluminescencesignalfromthehindlimb,forelimb,orpelvis/sacrum.Forlungmetastasis,anROIwasusedthatencompassedthethoraxofthemouse.F...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第1期ThePathophysiologyofWatershedInfarctioninInternalCarotidArteryDisease
...stingly,cerebralamyloidangiopathyhasrecentlybeenproposedasariskfactorformicroinfarctsintheCWSareas.24WhereastheseobservationsmainlyappliedtoCWSinfarction,arecentpathologicalstudy25of12patientswithIWSinfarctssuggestedthatischemiclesionsobservedintheIWSareamayalsoinvolveanembolicmechanism,eithercardia...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第3期PMA-andANGII-inducedPKCregulationoftherenalNa+-HCO3
...meanfluorescencesignalwasobtainedfromtheXYsectionwithintheregionofinterest(ROI)(dottedinFig.4A).Themeanvaluefornontreatedoocytes(Fig.4Aa)wasusedtonormalizethefluorescencesignalinoocytestreatedfor10minwith10nMPMA(Fig.4Ab).WefoundthatthehkNBCe1-EGFPfluorescenceinbothsetsofcellswasthesame,withthenear-m...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第3期SimultaneousDetectionofImmunoglobulinA(IgA)andIgMAntibodiesagainstHepatitisEVirus(HEV)IsHighlySpecificforDiagnosisofAcuteHEVInfection
...virus,p.3051-3061.InD.M.Knipe,P.M.Howley,D.E.Griffin,M.A.Martin,R.A.Lamb,B.Roizman,andS.E.Straus(ed.),Fieldsvirology,4thed.Lippincott/TheWilliamsWilkinsCo.,Philadelphia,Pa.Qadri,F.,E.T.Ryan,A.S.Faruque,F.Ahmed,A.I.Khan,M.M.Islam,S.M.Akramuzzaman,D.A.Sack,andS.B.Calderwood.2003.Antigen-specificimmuno...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第1期RGS2IsaMediatorofNitricOxideActiononBloodPressureandVasoconstrictorSignaling
...hrometer(TILLPhotonicsGmbH,Martinsried,Germany)inconjunctionwitha495-nmdichroicmirroranda525±20-nmemissionfilter(ChromaTechnologyCorp.,Brattleboro,VT).ToactivatePKG1invascularsmoothmusclecells(VSMCs),cellsweremountedintherecordingchamberasdescribedaboveandtreatedfor10minwith8-Br-cGMP(1mM)or8-pCPT-c...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期PreferentialmigrationofeffectorCD8+Tcellsintotheinterstitiumofthenormallung
...catedtimepointsaftertransfer.DataisrepresentedaspercentageofradioactivityinROIdefinedforthelungs,withthefractionoftransferredcells/radioactivitylocalizedtothelungs(80%)at1minutedefinedas100%.Resultsarerepresentativeof6independentexperiments.(C)Dualmodalityimageand(D)quantitationfollowingadoptivetran...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第12期Methylmercury-InducedIncreaseofIntracellularCa2+IncreasesSpontaneousSynapticCurrentFrequencyinRatCerebellarSlices
...rticallayerwereanalyzedusingLeicasoftware.Datafromseveralregionsofinterest(ROIs)definedwithinthislayerwereaveraged.ThebackgroundFluo-4fluorescencewassubtractedfromallROIsbeforeaveraging.StatisticalAnalysis.DatawereanalyzedstatisticallyusingStudent‘spairedttestorone-wayanalysisofvariance(ANOVA)forM...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第4期