Anewmethodfordeterminingplasmawatercontent:applicationinpseudohyponatremia
...omultiplemyelomawhodevelopssuperimposedtruehyponatremiainthesettingofmyelomakidney,itisvitallyimportanttodifferentiatethecomponentofhyponatremiathatisduetotruehyponatremiafromthatofpseudohyponatremia.Sinceinappropriatetreatmentofpseudohyponatremiacanleadtosignificantpatientmorbidity,Eq.5acanbeusedto...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第5期TheMetabolicSyndromeIsaStrongerRiskFactorforEarlyCarotidAtherosclerosisinWomenThaninMen
...(3%or25μm).17MeanIMTvaluesofnearandfarwallsofboththerightandleftarteries,takenfortheCCAsandICAsseparatelyandasanaveragevalueofallselectedsites,respectively,wereusedforstatisticalanalyses.Numberanddiameterofplaques,ifpresent,weremeasuredtoobtainanatherosclerosisscore(B-score).18StatisticsAnalyseswer...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第6期DifferencesinIschemicLesionEvolutioninDifferentRatStrainsUsingDiffusionandPerfusionImaging
...ischemiclesionevolutionbetweenSDandWKrats.TheseinterstrainvariationsmustbetakenintoaccountwhenassessingnewtherapeuticapproachesonischemiclesionevolutionintheratMCAOmodel.KeyWords:cerebralbloodflowdiffusion-weightedimagingfocalischemiaratstrainsIntroductionExperimentalmodelsofstrokeareessentialtostud...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第9期MidazolamMetabolisminCytochromeP4503AKnockoutMiceCanBeAttributedtoUp-RegulatedCYP2CEnzymes
...ug-metabolizingsystemsinhumans.Recently,ourgrouphasgeneratedcytochromeP4503Aknockoutmicetostudythisdrug-handlingsysteminvivo.Inthepresentstudy,wehavecharacterizedtheCyp3aknockoutmicebystudyingthemetabolismofmidazolam,oneofthemostwidelyusedprobestoassessCYP3Aactivity.Weexpectedthatthemidazolammetabol...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期GeranylgeranylacetoneProtectsMembranesagainstNonsteroidalAnti-InflammatoryDrugs
...sdevelopedinJapanandhasbecometheleadingantiulcerdrugontheJapanesemarket(Murakamietal.,1981).Inbothpreclinicalandclinicalstudies,ithasbeenshowntoprotectthegastricmucosaagainstthedevelopmentoflesionsinducedbyvariousirritants,includingNSAIDs,withoutaffectinggastricacidsecretion(Murakamietal.,1981;Teran...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第4期HemostaticActivationandOutcomeAfterRecombinantTissuePlasminogenActivatorTherapyforAcuteIschemicStroke
...e,at2hoursaftertreatment,andafter24hours.Results—TATandtPAantigenlevelspeakedat2hoursselectivelyinthertPAtreatmentgroup,whereasfibrinogenlevelsdroppedat2hoursandremainedlowafter24hours(P0.0001forinteractioneffectsbetweentimeandtreatment).At24hours,higherlevelsoftPAantigenwereassociatedwithalowerch...
醫源資料庫;在線期刊;中風學雜誌;2006年第37卷第7期三、動物腫瘤模型的選擇
...驗週期相對較長,所以一般很少用於篩藥。近年有人應用AKR自發白血病小鼠進行化研究,該小鼠出生後一年半內有高於90%的發病率,曾作爲研究人體白血病和淋巴瘤的模型,它對藥物的治療反應類似兒童急性淋巴性白血病。由於...
醫源資料庫;醫源圖書館;教材類;醫用實驗動物學趨化因子MIP-3α的克隆與表達
...中山公司,TALON金屬離子親和層析樹脂購自CLONTECH公司,AK-TAExplorer高效層析系統、Hiprep26.10除鹽柱、Hiprep16.10CMFF弱陽離子交換柱均購自英國AmershamPharmacia公司,其它化學試劑均爲分析純。 1.2方法 1.2.1總RNA提取標本收集後立...
醫源資料庫;在線期刊;局解手術學雜誌;2006年第15卷第2期Nachannelsintheratconnectingtubule
...herabbitandinrodents,canbeisolatedandperfusedinvitro.Itcanalsobesplitopen,makingtheapicalmembraneofthecellsaccessibletopatch-clamppipettes(16).ThereareseverallinesofevidenceforNachannel-mediatedtransportinearlierpartsofthedistalnephron,particularlytheconnectingtubule(CNT).Avarietyofmicropuncturedata...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第4期CognitiveConsequencesofThalamic,BasalGanglia,andDeepWhiteMatterLacunesinBrainAgingandDementia
...inimumof4weeksandcutinto1-cmcoronalslices.CaseswereclassifiedaccordingtoBraak21andThal22usinghighlyspecific,fullycharacterizedantibodiestomicrotubule-associatedproteinandtocore-amyloidA-proteinasdescribedelsewhere.4Antibodieswereamonoclonalanti-antibody(AT8,1/1000;Immunogenetics)andamonoclonalanti-A...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第6期