RestrictingZap70ExpressiontoCD4+CD8+ThymocytesRevealsaTCellReceptor–dependentProofreadingMechanismControllingtheCompletionofPositiveSelectio
...ingpharmacologicalagents(46)orantigen-presentingcells(17).Thegeneticstrategyusedinthepresentstudyclarifiesthesecontradictionsasitbypasseslimitationsinherenttoindirectapproaches.First,unlikeadoptivecelltransfers,thegeneticstrategyinterruptsTCRsignalingwithoutdisruptingMHC/TCRengagementsandotherpotent...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第3期Interleukin1ReceptorDependenceofSerumTransferredArthritisCanbeCircumventedbyToll-likeReceptor4Signaling
...-deficientmicetoendotoxin.Immunity.11:115–122.Firestein,G.S.,D.L.Boyle,C.Yu,M.M.Paine,T.D.Whisenand,N.J.Zvaifler,andW.P.Arend.1994.Synovialinterleukin-1receptorantagonistandinterleukin-1balanceinrheumatoidarthritis.ArthritisRheum.37:644–652.Arend,W.P.,andJ.M.Dayer.1995.Inhibitionoftheproductiona...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第3期Interleukin1ReceptorDependenceofSerumTransferredArthritisCanbeCircumventedbyToll-likeReceptor4Signaling
...-deficientmicetoendotoxin.Immunity.11:115–122.Firestein,G.S.,D.L.Boyle,C.Yu,M.M.Paine,T.D.Whisenand,N.J.Zvaifler,andW.P.Arend.1994.Synovialinterleukin-1receptorantagonistandinterleukin-1balanceinrheumatoidarthritis.ArthritisRheum.37:644–652.Arend,W.P.,andJ.M.Dayer.1995.Inhibitionoftheproductiona...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第3期Reversalofdiet-inducedhepaticsteatosisandhepaticinsulinresistancebyantisenseoligonucleotideinhibitorsofacetyl-CoAcarboxylases1and2
...iuminjection(150mg/kg)andalltissuesweretakenwithin4minutes,frozenimmediatelyusingliquidN2-cooledaluminumtongs,andstoredat–80°Cforsubsequentanalysis.Biochemicalanalysisandcalculations.Plasmaglucosewasanalyzedduringtheclampsusing10μlplasmabyaglucoseoxidasemethodonaBeckmanCoulterglucoseanalyzerII(B...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期IFN-productionbyalloantigen-reactiveregulatoryTcellsisimportantfortheirregulatoryfunctioninvivo
...contrasttofindingsafterexvivoorinvitrostimulation,CD25+CD4+Tcellstransientlyup-regulateIFN-mRNAexpressionafteralloantigenexposureinvivo.ThisincreaseinIFN-transcriptionisantigenspecificandisnotaresultofcontaminationwithantigen-experiencedorrecentlyactivatedTcells.Furthermore,neutralizationexperiments...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第12期SelectiveactivationofSTAT5unveilsitsroleinstemcellself-renewalinnormalandleukemichematopoiesis
...o,Tokyo113-0032,Japan4FirstDepartmentofInternalMedicine,FacultyofMedicine,KyushuUniversity,Fukuoka812-8582,Japan5ERATO,AkiraInnateImmunityProgram,JapanScienceandTechnologyAgency,ResearchInstituteforMicrobialDiseases,OsakaUniversity,Osaka565-0871,Japan6DepartmentofCellularandMolecularMedicine,Graduat...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第1期Cortistatin,anewantiinflammatorypeptidewiththerapeuticeffectonlethalendotoxemia
...ngessimilartohumansepticshocksyndrome,andlethalendotoxemiahasbeenextensivelyusedasanexperimentalmodelofGram-negativesepticshock(1).Thesepticshocksyndromeischaracterizedbyahyperactiveandout-of-balancenetworkofendogenousproinflammatorycytokines,includingTNF,IL-12,IL-6,andIFN(2).Theoverproductionofinfl...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第3期QuantitativePCRAssayUsingSputumSamplesforRapidDiagnosisofPneumococcalPneumoniainAdultEmergencyDepartmentPatients
...astoevaluatethepotentialclinicalutilityofarapidquantitativereal-timePCRassayusingsputumsamplesforStreptococcuspneumoniaeinadultpatientswithcommunity-acquiredpneumonia(CAP).AprospectiveclinicalobservationalstudyofconsecutivelyenrolledemergencydepartmentpatientswithCAPwasperformed;onlythosepatientswit...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期新發現挑戰“寄主制裁論”
...瘤。但這種共生體的進化機制尚不清楚。 寄主制裁論一直是被普遍接受的理論,然而,另一種叫做夥伴忠誠回饋的理論則認爲共生體系在進化過程中形成了健康寄主自動與寄生者分享利益的機制,而不是獎勵或懲罰。一個作...
醫藥經濟;生物技術;技術要聞AID-dependenthistoneacetylationisdetectedinimmunoglobulinSregions
...lldocumentedintranscriptionregulation,itsroleinDNAdamagerepairremainslargelyunexplored.The1B4.B6BcelllineandnormalsplenicBcellswereactivatedtoundergoCSRandanalyzedforhistoneAcbychromatinimmunoprecipitation(ChIP).AdetailedstudyoftheI3-S3-C3locusdemonstratedthatacetylatedhistonesarefocusedtotheI3exona...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第1期