Rapamycinatsubimmunosuppressivelevelsinhibitsmesangialcellproliferationandextracellularmatrixproduction
...provenantiproliferativeeffects,rapamycinofferspotentialinthetreatmentofmesangioproliferativedisease.Previousdatahaveshownaneffectofrapamycinonmesangialcellproliferationathighdosesandhavenotexploredthemechanismofaction.Therefore,weexploredtheeffectsandmechanismofactionoflowlevelsofrapamycinonmesangia...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第1期自殺基因TK聯合細胞因子FL真核表達載體的構建及其相關特性的研究
...白水平的表達,ELISA法測定FL分泌量爲每4天105個細胞中15.7ng/ml,它具有刺激CD34+細胞增殖的活性。結論 MCF-7/TK-FL細胞可同時表達TK與FL基因,在自殺基因瘤苗的基礎上,其分泌的細胞因子FL具有生物活性,可作爲進一步加強免疫細...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學雷公藤內酯醇誘導人淋巴細胞凋亡的作用與細胞週期的關係
...cellcycleandapoptosisofactivatedTlymphocyctes inducedbytriptolideLIUDong,YANGJun-Wei,CHENZhao-Hongetal. ResearchInstituteofNephrology,JinlingHospital,SchoolofMedicine,NanjingUniversity,Nanjing210002 Abstract Objective:Inordertoexploredthemechanismsoftriptolide-inducedapoptosis,there...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學ResveratrolSuppressesTumorNecrosisFactor--InducedFractalkineExpressioninEndothelialCells
...nducedfractalkinemRNAandproteinexpressioninendothelialcells.ResveratrolstronglysuppressedTNF--inducedfractalkineexpressioninendothelialcellsthroughsuppressionofnuclearfactor-BandSp1activities.ResveratroldecreasedthenumberofTNF--inducedfractalkine-positiveendothelialcellsandCX3CR1-positivecellsdeterm...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第7期VitaminDsupplementationimprovescytokineprofilesinpatientswithcongestiveheartfailure:adouble-blind,randomized,placebo-controlledtrial
...,32545BadOeynhausen,Germany.E-mail:azittermann{at}hdz-nrw.de.Seecorrespondingeditorialonpage731.SeecorrespondingCMEexamonpage925.ABSTRACTBackground:Elevatedcirculatingconcentrationsofproinflammatorycytokinesmaycontributetothepathogenesisofcongestiveheartfailure(CHF).InvitrostudiessuggestthatvitaminD...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年83卷第4期鍼灸治腓總神經麻痹
...://www.zysj.com.cn/lilunshuji/huangdisuwen/index.html“target=“_blank“title=“中醫書籍:黃帝黃帝內經·素問》曰:“因於溼,首如裹,溼熱不攘,大筋軟短,小筋弛長,軟短爲拘,弛長爲痿。”《素問·玄機原病式》曰:“痿,謂手足痿弱...
中醫中藥;中醫臨牀;臨牀討論有機硝酸酯類藥物品種與給藥方案比較與選擇
...甘油耐受性,血藥濃度與效應關係不大平均血藥濃度0.81ng/ml,毛細血管楔壓無變化平均血藥濃度7.35ng/ml,毛細血管楔壓有變化但由於個體藥效學差異大,及耐受性等因素,血濃度無臨牀意義與價值由於上述硝酸甘油特殊性,故現...
醫源資料庫;醫學文檔庫;心血管相關ComparativeEffectsofPaclitaxelandRapamycinonSmoothMuscleMigrationandSurvival
...asepathwayssimilarly.However,rapamycinpotentlyactivatesAKT-dependentsignaling,aneffectthatoverridesthedownregulationofthispathwaybyinsulinresistanceandthatcausesphosphorylationoftheAKT-dependenttranscriptionfactorFOXO1.Thiseffectisassociatedwithattenuationoftheanti-migratoryeffectsofrapamycinunderhi...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第7期尼莫地平在大鼠體內的藥物代謝動力學研究
....0ml/min,柱溫35℃,檢測波長240nm。尼莫地平血漿在10~3200ng·ml-1範圍,具有良好線性關係,Y=691C+415,R=0.9998,提取回收率90.4%~103.0%,方法回收率97.0%~105.3%。大鼠灌胃給藥10mg·kg-1,20mg·kg-1,40mg·kg-1。...
合作平臺;醫學論文;臨牀醫學與專科論文;藥學ThematrixcomponentbiglycanisproinflammatoryandsignalsthroughToll-likereceptors4and2inmacrophages
...crophagesasanendogenousligandofTLR4andTLR2,whichmediateinnateimmunity,leadingtorapidactivationofp38,ERK,andNF-BandtherebystimulatingtheexpressionofTNF-andmacrophageinflammatoryprotein–2(MIP-2).Inagreement,thestimulatoryeffectsofbiglycanaresignificantlyreducedinTLR4-mutant(TLR4-M),TLR2–/–,andmy...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第8期