MolecularMechanismsofVascularCalcification
...orticMACMACisahighlycharacteristicfeatureofdiabetesandchronickidneydisease(CKD).3,4AlthoughdiabetesisthemajorcauseofCKD,hyperglycemiaconveysindependentriskforvascularcalcification.5,7Aorticcalciumscores,butnotcoronarycalciumscores,arelinearlyrelatedtofastingbloodglucose.8MAChasemergedasanexceptional...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第7期Acidosisimpairsinsulinreceptorsubstrate-1-associatedphosphoinositide3-kinasesignalinginmusclecells:consequencesonproteolysis
...zesexcessacid,andregeneratesbicarbonate.Inpatientswithchronickidneydisease(CKD),thekidneycannotefficientlygenerateammonium,leadingtochronicmetabolicacidosisthathasbeenwellestablishedtoactasastimulusforproteincatabolisminmuscle,(12,35).Thisleadstolossofleanbodymassthatcontributestomorbidityandmortali...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第10期ReducedOxidantStressandExtendedLifespaninMiceExposedtoaLowGlycotoxinDiet
...moninaging,includingdiabetes,cardiovasculardisease,andchronickidneydisease(CKD).15,16,18-21,24-26Nutrientsthatarethermallypreparedforconsumptionarearichsourceofprotein-orfat-derivedoxidationderivatives,includingAGEs,andahostoftoxiccompoundsinfoods,someofwhichhavebeenimplicatedinoncogenesis.27-32Labo...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第6期Hepatocytegrowthfactorinkidneyfibrosis:therapeuticpotentialandmechanismsofaction
...lecularmechanismsthatunderlieitsactionsinthesettingofchronickidneydiseases(CKD)(24,58,59,80).ThisarticleattemptstoprovideaconcisereviewonthetherapeuticpotentialofHGFinchronicrenalfibrosis.EmphasisisplacedonrecentadvancesinourunderstandingofthecellularandmolecularbasisofHGFactions.HGF:APOTENTANTIFIBR...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第7期PTH(1-84)/PTH(7-84):abalanceofpower
...ionalreabsorptionofphosphoruswithinthenephron.Advancedchronickidneydisease,CKD3-5(60a),isalmostinvariablyaccompaniedbysecondaryhyperparathyroidisminindividualswhoareuntreated.Thehallmarksofsecondaryhyperparathyroidismduetochronickidneydiseaseincludereductionsinrenalcalcitriolproductionwithdiminished...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第5期Erlotinib,anEffectiveEpidermalGrowthFactorReceptorTyrosineKinaseInhibitor,Inducesp27KIP1Up-RegulationandNuclearTranslocationinAssociationwit
...nationshowedthaterlotinibtreatmentledtop27KIP1translocationtothenucleus.Knockdownofp27KIP1expressionwithp27KIP1smallinterferingRNAsignificantlyabrogatederlotinib-inducedG1phasearrestandcellgrowthinhibition,suggestingthatinductionofp27KIP1isrequiredforG1arrestandcellgrowthinhibitionbyerlotinib.Itisno...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第8期ReceptorTyrosineKinaseEphBIsaSurvivalFactorinBreastCancer
...tsnaturalligand,EphrinB2,andsignaledviatheproteinkinaseBpathway.TargetedknockdownofEphB4expressionbysmallinterferenceRNA(andantisenseoligodeoxynucleotides(ODNs))ledtodose-dependentreductionincellsurvival,increasedapoptosis,andsensitizationtotumornecrosisfactor-relatedapoptosis-inducingligand(TRAIL)....
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第7期現代名中醫外科絕技
...提供了寶貴的經驗和醫學資料。目錄:周鳳梧冰朱蓖麻膏治療疔朱仁康消託兼施治外瘍顧伯華治療流注夏少農治療外科急症的經驗唐漢鈞重症有頭疽的辨證治療方致和扶正溫經託毒治療腦疽凌雲鵬舒筋活血湯治療髂...
醫源資料庫;醫源書店;專家醫話中西醫治肝癌各顯神通
治療肝癌可採取多種力法,如西醫、中醫、中西醫結合治療,下面簡介幾種治療力法。西醫治療肝癌方法:治療肝癌的方法有兩種,消滅腫瘤、支持機體。1、消滅腫瘤的方法:切除和相當於切除的方法.如徹底的激光氣化與冷...
醫源資料庫;醫學論文;中醫中藥;中西醫結合心理治療的發展趨勢
...】Psychotherapy;Pevelopmentaltrends 近二十年來,無論是心理治療理論,還是治療技術方面都取得了很大的進展。在理論方面,越來越多的研究支持這樣一種觀點:任何一種單一的理論(情緒的、認知的、生理的或行爲的)都不足以解...
合作平臺;醫學論文;基礎醫學論文;醫學心理學