ExtracellularLoop3(EL3)andEL3-ProximalTransmembraneHelix7oftheMammalianTypeIandTypeIIGonadotropin-ReleasingHormone(GnRH)ReceptorsDetermin

...II.Point-mutationstudiesindicatethatfouraminoacids,Leu/Phe7.38,Leu/Phe7.43,Ala/Pro7.46,andPro/Cys7.47inTMH7arecriticalforligandselectivityaswellasreceptorconformation.Furthermore,acombinatorymutation(Pro7.31-Pro7.32-Ser7.33motiftoSer-Glu-ProinEL3andLeu7.38,Leu7.43,Ala7.46,andPro7.47tothoseofratGnRHR...

PreparingaSelenomethionylProtein

PreparingaSelenomethionylProtein：bySaraLindgren,01/22/2000Purpose：Theprotocoldescribeshowtoprepareselenomethionyl(Se-Met)proteinusingaregularE.colistrain.Seleniumcanbeusedforphasedeterminationinmulti-wavelengthanomalousdiffraction(MAD)method.Se-Metcanoftenreplacemethionineresiduesinaproteinwitho...

ACE-VersusChymase-DependentAngiotensinIIGenerationinHumanCoronaryArteries

...ecurvestoangiotensinII,angiotensinI,andthechymase-specificsubstratePro11-D-Ala12–angiotensinI(PA–angiotensinI)wereconstructed.Allangiotensinsdisplayedsimilarefficacy.Foragivenvasoconstriction,bath(butnotinterstitial)angiotensinIIduringangiotensinIandPA–angiotensinIwaslowerthanduringangiotensin...

CapsaicinRegulatesVoltage-DependentSodiumChannelsbyAlteringLipidBilayerElasticity

...volvedinnociception.Atmicro-tomillimolarconcentrations,commonlyusedinclinicalandinvitrostudies,capsaicinalsomodulatesthefunctionofalargenumberofseeminglyunrelatedmembraneproteins,manyofwhicharesimilarlymodulatedbythecapsaicinantagonistcapsazepine.Themechanism(s)underlyingthiswidespreadregulationofpr...

武漢市區291名幼兒血鉛水平與貧血的關係

...齡分爲2～4歲組和4～7歲組，同時測定紅細胞計數、血紅蛋白水平。結果兩組中2～4歲幼兒紅細胞計數、血紅蛋白水平差異無顯著性（P0.05），而4～7歲幼兒紅細胞計數、血紅蛋白水平差異有顯著性（P0.05）。結論鉛中毒兒童中較大...

AMCase基因突變體克隆成功

...（氨基酸392~425）和結合區（氨基酸426~473）組成。編碼的蛋白質在催化區和鉸鏈區分別發生了突變，292位氨基酸由丙氨酸（Ala）突變爲脯氨酸（Pro），404位氨基酸由蘇氨酸（Thr）突變爲絲氨酸（Ser）。　　據陳凌介紹，從幾丁質...

Dietaryintakeofn–3andn–6fattyacidsandtheriskofprostatecancer

...Objective:Weprospectivelyevaluatedtheassociationbetweenintakesof-linolenic(ALA;18:3n–3),eicosapentaenoic(EPA;20:5n–3),docosahexaenoic(DHA;22:6n–3),linoleic(LA;18:2n–6),andarachidonic(AA;20:4n–6)acidsandprostatecancerrisk.Design:Acohortof47866USmenaged40–75ywithnocancerh...

缺血修飾白蛋白與急性冠狀動脈綜合徵的關係研究

【摘要】目的找出缺血修飾白蛋白（IMA）與急性冠狀動脈綜合徵的關係。方法通過對23例急性心肌梗死患者（AMI組）、48例不穩定型心絞痛患者（UAP組）和150例健康對照組的IMA的檢測，對數據進行統計分析。結果AMI組和UAP組比對...

乳製品中L-羥脯氨酸的檢測

1前言：“皮革奶”添加物的主要成分是皮革水解蛋白（即動物皮毛，含大量角質蛋白質），其中劣質水解蛋白的生產原料主要來自制革工廠的邊角廢料，製革邊角廢料中含有重鉻酸鉀和重鉻酸鈉，用這種原料生產水解蛋白，重...

PPARandhumanmetabolicdisease

...zesthekeyrolesofPPARintheentrainingofhumanintermediarymetabolismtonutritionalandotherenvironmentalcues.Table1Simplifiedoverviewofcurrentunderstandingofthemetabolicrolesofthe3PPARisoformsPPARmolecularstructureandfunction.PPARsaremembersofthenuclearhormonereceptorsuperfamilythatbindtospecificDNArespon...