MechanismsofCardiolipinOxidationbyCytochromec:RelevancetoPro-andAntiapoptoticFunctionsofEtoposide
【關鍵詞】MechanismsExecutionofapoptoticprograminmitochondriaisassociatedwithaccumulationofcardiolipinperoxidationproductsrequiredforthereleaseofproapoptoticfactorsintothecytosol.Thissuggeststhatlipidantioxidantscapableofinhibitingcardiolipinperoxidationmayactasantiapoptoticagents.Etoposide,awi...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第8期StaphylococcusaureusPanton-ValentineleukocidindirectlytargetsmitochondriaandinducesBax-independentapoptosisofhumanneutrophils
...fPVLtoisolatedmitochondriainducedthereleaseoftheapoptogenicproteinscytochromecandSmac/DIABLO.Therefore,wesuggestthatPVL,whichbelongstothepore-formingtoxinfamily,couldactatthemitochondrionlevelbycreatingporesinthemitochondrialoutermembrane.Furthermore,LukS-PV,1ofthe2componentsofPVL,wasdetectedinlungs...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第11期RatrenalcorticalOAT1andOAT3exhibitgenderdifferencesdeterminedbybothandrogenstimulationandestrogeninhibition
...3,inthegenerationofthesegenderdifferences,aswellastheresponsiblehormonesandmechanisms,hasnotbeenclarified.Hereweusedvariousimmunocytochemicalmethodstostudyeffectsofgender,gonadectomy,andtreatmentwithsexhormonesonlocalizationandabundanceofOAT1andOAT3alongtheratnephron.Bothtransporterswerelocalizedtot...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第7期MutationswithinSox2/SOX2areassociatedwithabnormalitiesinthehypothalamo-pituitary-gonadalaxisinmiceandhumans
...ogicaldefectsmayoriginatefromchangesintheoverlyinginfundibulum(13).AsimilarmechanismmightbeoperatingforSox2,butunlikeSox3,thisisalsoprominentlyexpressedinRathke??spouch,soasimplerexplanationinthiscasecouldbea“pouch-autonomous“defect,notcompensatedforbyredundancyfromotherSoxgenes.Thereductioninso...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第9期