白細胞介素12及其抗腫瘤作用
IL-12是新近發現的一種細胞因子,具有多種生物學活性,尤其是在抗腫瘤免疫和抗病毒免疫中有重要的作用。 一、IL-12概況 IL-12主要來源於單核/巨噬細胞、抗原遞呈細胞和B細胞,是由相對分子質量爲40×103和35×103兩個亞...
合作平臺;醫學論文;外科論文;普通外科學EffectoforalvitaminB-12withorwithoutfolicacidoncognitivefunctioninolderpeoplewithmildvitaminB-12deficiency:arandomized,placebo-controll
...tQLK3-CT-2002-01775fromtheFoundationtoPromoteResearchIntoFunctionalVitaminB12DeficiencyandtheEuropeanUnionBIOMEDDemonstrationProject;andgrant2004-E2fromtheNutriciaHealthFoundation,Wageningen,Netherlands.3AddressreprintrequeststoLCdeGroot,DivisionofHumanNutrition,WageningenUniversity,POBox8129,6700EV...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年84卷第2期TransgenicOverexpressionofADAMSuppressesMuscleRegenerationandAggravatesDystrophyinAgedmdxMice
...rationandgradualreplacementoftheskeletalmusclebyfatandconnectivetissue.ADAM12haspreviouslybeenshowntoalleviatethepathologyofyoungdystrophin-deficientmdxmice,amodelforDuchennemusculardystrophy.TheobservedeffectofADAM12wassuggestedtobemediatedviaamembrane-stabilizingup-regulationofutrophin,7Bintegrin,...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第11期MMP-12與動脈粥樣硬化
...Collagenases(MMP-1,-8,-13)Gelatinases(MMP-2,-9)Stromelysins(MMP-3,-10,-11,-12)Membrane-typeMMPs(MMP-14~17and-24~25)Others:matrilysin(MMP-7,-19-24,-26)TheFunctionsofMMPsPhysiological:EmbryonicdevelopmentOrganmorphogenesisNervegrowthBoneremodelingWoundhealingOvulationAngiogenesisPathological:Emphysema...
醫源資料庫;醫學文檔庫;心血管相關2009國家自然科學基金項目(生物類)
...學170人類NADPHsensor蛋白HSCARG調控機制研究鄭曉峯30930020/C05012010-01至2013-12北京大學180結構修飾的siRNA合成和RNA干擾技術在藥物靶標尋找中的研究張禮和20932001/B0207022010-01至2013-12北京大學180p53和PTEN之間的分子聯繫研究尹玉新30930021/C05...
醫學教育;科教新聞RemovalofFkbp12/12.6FromEndothelialRyanodineReceptorsLeadstoanIntracellularCalciumLeakandEndothelialDysfunction
【摘要】Objectives-FK506BindingProtein12anditsrelatedisoform12.6(FKBP12/12.6)stabilizeaclosedstateofintracellularCa2+releasechannels(ryanodinereceptors),andinmyocytesremovalofFKBP12/12.6fromRyRsaltersintracellularCa2+levels.TheimmunosuppressivedrugsrapamycinandFK506bindanddisplaceFKBP12/12.6from...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第7期Transcobalamin776CGpolymorphismnegativelyaffectsvitaminB-12metabolism
...C)776CG]mayaffectthefunctionoftranscobalamin,theproteinrequiredforvitaminB-12cellularuptakeandmetabolism.Remethylationofhomocysteineisdependentontheproductionof5-methyltetrahydrofolateandadequatevitaminB-12forthemethioninesynthasereaction.Objectives:TheobjectivesweretoassesstheinfluenceoftheTC776CGp...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年81卷第6期5.11維生素B12
5.11維生素B12 5.11.1結構與性質 維生素B12(VB12)爲鈷胺素(Cobalamin)類化合物,他的分子中有4個還原性吡咯環聯結在一起,這種構叫做咕啉,他與核苷酸(二甲基苯異咪唑)及核糖相聯,另一方面與D-1-氨基-2-丙醇相...
醫源資料庫;醫源圖書館;教材類;臨牀營養學Holo-transcobalaminisanindicatorofvitaminB-12absorptioninhealthyadultswithadequatevitaminB-12status
...eenhypothesizedthattheresponseofholo-transcobalamin(holo-TC)tooralvitaminB-12maybeusedtoassessabsorption.Todevelopareliableclinicalabsorptiontestthatusesholo-TC,itisnecessarytodeterminetheoptimaltimelineforvitaminB-12administrationandpostdoseassessment.Objective:Theobjectiveofthisstudywastoassessthe...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第4期FolateandvitaminB-12statusinrelationtoanemia,macrocytosis,andcognitiveimpairmentinolderAmericansintheageoffolicacidfortification
...olicacidfortificationdelaysthediagnosisoforexacerbatestheeffectsofvitaminB-12deficiency,whichaffectsmanyseniors.Thisideaiscontroversial,however,becauseobservationaldataarefewandinconclusive.Furthermore,experimentalinvestigationisunethical.Objective:WeexaminedtherelationsbetweenserumfolateandvitaminB...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第1期