C-ReactiveProteinDecreasesInterleukin-10SecretioninActivatedHumanMonocyte-DerivedMacrophagesviaInhibitionofCyclicAMPProduction
【摘要】Objective-C-Reactiveprotein(CRP),acardiovascularriskmarker,couldalsoparticipateinatherosclerosis.AtheroscleroticplaquesexpressCRPandinterleukin(IL)-10,amajorantiinflammatorycytokine.IL-10deficiencyresultsinincreasedlesionformation,whereasIL-10deliveryattenuateslesions.Wetestedtheeffectof...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第11期One-timegradeddosesofvitaminAtoweanlingpigletsenhancehepaticretinolbutdonotalwayspreventvitaminAdeficiency
RebeccaLSurles,JordanPMills,AshleyRValentineandSherryATanumihardjo1FromtheInterdepartmentalGraduatePrograminNutritionalSciences,UniversityofWisconsin–Madison,Madison,WI2PresentedinpartattheExperimentalBiology2006meeting,SanDiego,CA,andatthe2007MicronutrientForum,Istanbul,Turkey.3SupportedbyNIH...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年86卷第4期RosiglitazoneReducesGlucose-InducedOxidativeStressMediatedbyNAD(P)HOxidaseviaAMPK-DependentMechanism
【摘要】Objective—Hyperglycemiaisthemaindeterminantoflong-termdiabeticcomplications,mainlythroughinductionofoxidativestress.NAD(P)Hoxidaseisamajorsourceofglucose-inducedoxidativestress.Inthisstudy,wetestedthehypothesisthatrosiglitazone(RSG)isabletoquenchoxidativestressinitiatedbyhighglucos...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第12期NADPHOxidase-DerivedOverproductionofReactiveOxygenSpeciesImpairsPostischemicNeovascularizationinMicewithTypeDiabetes
【摘要】Wehypothesizedthatdiabetes-inducedoxidativestressmayaffectpostischemicneovascularization.Theresponsetounilateralfemoralarteryligationwasstudiedinwild-typeorgp91phox-deficientcontrolortype1diabeticmiceorinanimalstreatedwiththeanti-oxidantN-acetyl-L-cysteine(NAC)orwithinvivoelectrotransfer...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第8期IncreasedPI3-KinaseinPresympatheticBrainAreasoftheSpontaneouslyHypertensiveRat
theDepartmentofPhysiologyandFunctionalGenomics(S.J.V.,M.Y.,M.K.R.),UniversityofFlorida,GainesvilletheDepartmentsofPhysiology(K.H.B.)andCellBiology(M.W.),UniversityofAlabama,Birmingham.AbstractExistingevidenceledustohypothesizethatincreasesinp85,aregulatorysubunitofPI3-kinase,inpresympatheticbrainare...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第2期急性白血病MTS1/P16基因缺失的研究
...因素及染色體異常與它的發生都有關係。現已證實,MTS1/P16基因在人類多種惡性腫瘤中存在着不同形式的改變[1,2],但有關MTS1/P16基因在急性白血病中的研究國內報道少[3]。我們採用差別PCR技術對MTS1/P16基因在急性白血病中...
合作平臺;醫學論文;基礎醫學論文;免疫學甘芪益腎凍乾粉對腎病綜合徵模型大鼠的治療作用
...給予凍乾粉5周後各治療組24h總尿量比模型組明顯提高(P<0.05);24h尿蛋白量在給藥後2、3、4周顯著下降(P<0.05);其作用強度有明顯劑量依賴關係,但低劑量組治療5周後24h尿蛋白量與模型組無明顯差異(P>0.05);甘芪益腎...
醫源資料庫;在線期刊;中華實用醫藥雜誌;2006年第6卷第4期NAD(P)HOxidaseeCDependentSelf-PropagationofHydrogenPeroxideandVascularDisease
theSectionofCardiology,DepartmentofMedicine,TheDivisionofBiologicalSciencesandPritzkerSchoolofMedicine,TheUniversityofChicago,Ill.AbstractExcessiveproductionofreactiveoxygenspeciesinthevasculaturecontributestocardiovascularpathogenesis.Amongbiologicallyrelevantandabundantreactiveoxygenspecies,supero...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第4期EffectsofacuteandchronicL-argininetreatmentinexperimentalhyperuricemia
【摘要】Experimentalhyperuricemia(HU)resultsinpreglomerulararteriolopathy,corticalvasoconstriction,andglomerularhypertension.Recently,uricacidhasbeenshowntoinduceendothelialdysfunction.WethereforestudiedtheeffectofacuteandchronicadministrationofL-arginine(asubstrateforendothelialnitricoxidesynth...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第4期BoswellicAcidsStimulateArachidonicAcidReleaseand12-LipoxygenaseActivityinHumanPlateletsIndependentofCa2+andDifferentiallyInteractwithPlatel
...oswellicacidsinhibitthetransformationofarachidonicacidtoleukotrienesvia5-lipoxygenasebutcanalsoenhancetheliberationofarachidonicacidinhumanleukocytesandplatelets.Usinghumanplatelets,weexploredthemolecularmechanismsunderlyingtheboswellicacid-inducedreleaseofarachidonicacidandthesubsequentmetabolismby...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第9期