TheimpactofDMonMHCclassII–restrictedantigenpresentationcanbealteredbymanipulationofMHC–peptidekineticstability
...gglysozyme;SWM,spermwhalemyoglobin.Stimulationofantigen-specificCD4TcellsrequiresthepresentationofimmunogenicpeptideepitopesinassociationwithMHCclassIImoleculesonthesurfaceofprofessionalAPCs.TheassemblyandexportoftheseclassII–peptidecomplexesisaregulatedmultistepprocess,culminatingintheexchangeofC...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第5期AberrantTcelldifferentiationintheabsenceofDicer
...ogy,HarvardMedicalSchool,Boston,MA02115DicerisanRNaseIII-likeenzymethatisrequiredforgeneratingshortinterferingRNAsandmicroRNAs.Thelatterhavebeenimplicatedinregulatingcellfatedeterminationininvertebratesandvertebrates.TotesttherequirementforDicerincell-lineagedecisionsinamammalianorganism,wehavegener...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第2期AmutationintheIcsbp1genecausessusceptibilitytoinfectionandachronicmyeloidleukemia–likesyndromeinBXH-2mice
...eStudyofHostResistance,DepartmentofHumanGenetics,McGillUniversity,Montreal,QuebecH3G1Y6,Canada3BiotechnologyResearchInstitute,Montreal,QuebecH4P2R2,CanadaBXH-2micedevelopafatalmyeloidleukemiabyatwo-stepmutagenicprocess.First,aBXH-2–specificrecessivemutationcausesamyeloproliferativesyndrome.Second,...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第6期Anti-CD63antibodiessuppressIgE-dependentallergicreactionsinvitroandinvivo
...tivationinthiscomplexprovidesaCa2+-independentsignalfordegranulationbysubsequentactivationofPDK-1andtheCa2+-independentproteinkinaseC-(PKC).SeveralinhibitoryreceptorssuppressFcRI-inducedMCfunctions.TheyincludetheMCfunction–associatedmoleculeMAFA,gp49BI,FcRIIB,andthepairedimmunoglobulin-likerecepto...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第3期RelationshipbetweentheOriginalMultiplyResistantSouthAfricanIsolatesofStreptococcuspneumoniaefrom1977to1978andContemporaryInternationalResis
...minitialoutbreaksinSouthAfricafrom1977to1978werecharacterizedbymultilocussequencetypingandpulsed-fieldgelelectrophoresis.Twenty-oneisolateswerepenicillinresistantandfivewerepenicillinintermediate,withvariablesusceptibilitiestomacrolides,clindamycin,chloramphenicol,tetracycline,andtrimethoprim-sulfam...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第12期Reemergenceofemm1andaChangedSuperantigenProfileforGroupAStreptococciCausingInvasiveInfections:ResultsfromaNationwideStudy
...ococcal(GAS)isolatesfromclinicalmicrobiologicaldepartmentsinDenmarkandsubsequently487(98%)questionnairesfromtheclinicianstreatingthepatientswerereceivedaspartofanationalsurveillance.emmtypesandstreptococcalsuperantigen(SAg)genesweredetermined.TheincidenceofinvasiveGASinfectionswasonaverage2.3per100,...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期Conditionaldeletionrevealsacell-autonomousrequirementofSLP-76forthymocyteselection
...naltransductioninprimarythymocytesandperipheralTlymphocytes.ToevaluatetherequirementsforSLP-76intheseevents,weusedacre-loxPapproachtogeneratemicethatconditionallydeleteSLP-76aftertheDN3checkpoint.ThesemicedevelopDPthymocytesthatexpresstheTCRonthesurface,butlackSLP-76atthegenomicDNAandproteinlevels.T...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第7期AminoAcidsCriticalforSubstrateAffinityofRatOrganicCationTransporter1LinetheSubstrateBindingRegioninaModelDerivedfromtheTertiaryStructu
...ously,andhowsubstratebindinginitiatesthetranslocationprocess.Intheend,thesequestionscanonlybesolvedbythecrystallizationofligand-transportercomplexesincombinationwithfunctionalcharacterizationofpointmutationsofcriticalresidues.Inrecentyears,thefunctionaleffectsofmanyindividualpointmutationsontranspor...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期LongQTsyndrome:fromchannelstocardiacarrhythmias
...armacology,ColumbiaUniversityMedicalCenter,NewYork,NewYork,USA.AbstractLongQTsyndrome,araregeneticdisorderassociatedwithlife-threateningarrhythmias,hasprovidedawealthofinformationaboutfundamentalmechanismsunderlyinghumancardiacelectrophysiologythathascomeaboutbecauseoftrulycollaborativeinteractionsb...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第8期小鼠鐵過量模型建立及相關指標的觀察研究
【摘要】目的給小鼠喂以全價顆粒飼料輔以定期定量腹腔注射右旋糖酐鐵,快速建立高鐵動物模型並觀察動物體內鐵水平及臟器係數的變化。方法將雌雄各半的昆明小鼠隨機分爲4組,以不同濃度的右旋糖酐鐵隔日腹腔注射(IP)...
醫源資料庫;在線期刊;齊魯醫學雜誌;2008年第23卷第4期