熱休克蛋白Hsp12可穩定細胞膜
儘管熱休克蛋白Hsp12被證實可幫助細胞在脅迫條件下存活,但是它的作用機理仍不清楚。近日德國的研究者在《分子細胞》(MolecularCell)期刊上發表論文揭示了Hsp12的保護機制。不同於其他的熱休克蛋白,細胞溶膠中非摺疊的Hsp1...
行業資訊;臨牀快報;細胞分子與蛋白質組TrendsinbloodfolateandvitaminB-12concentrationsintheUnitedStates,1988–
...wpopulationconcentrationsofserumandredbloodcell(RBC)folateandserumvitaminB-12havechangedoverthepast2decades.Design:MeasurementofbloodindicatorsoffolateandvitaminB-12statuswasconductedin23000participantsintheprefortificationthirdNationalHealthandNutritionExaminationSurvey(NHANESIII;1988–1994)an...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年86卷第3期AcinarCellsContributetotheMolecularHeterogeneityofPancreaticIntraepithelialNeoplasia
...thecellularandmolecularchangesthatoccurinacinarandductcellpropertiesonKrasG12Dexpression,wetookadvantageofLSL-KrasG12D/+/p48Cre/+mice,whichfaithfullymimicthehumandisease.Inyounganimals(4weeks),thepredominantcellularalterationintheexocrinepancreaswasacinarmetaplasiainwhichindividualaciniconsistedofac...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第7期Anovelargininesubstitutionmutationin1Adomainandanovel27bpinsertionmutationin2Bdomainofkeratin12geneassociatedwithMeesmann’scornealdy
...rophy.Methods:Mutationalanalysisofdomains1Aand2Bofthekeratin3(K3)andkeratin12(K12)genesfromtwopatientswithMeesmann’scornealdystrophywasperformedbypolymerasechainreactionamplificationanddirectsequencing.Results:NovelmutationsoftheK12genewereidentifiedinbothpatients.Inonepatientaheterozygouspointmut...
醫源資料庫;在線期刊;英國眼科學雜誌;2004年第88卷第6期Adenosine2AreceptorvasodilationofratpreglomerularmicrovesselsismediatedbyEETsthatactivatethecAMP/PKApathway
...nsestoA2ARactivationbyaselectiveA2Aagonist,CGS-21680,comparedwiththoseof11,12-EET.MaleSprague-Dawleyratswereanesthetized,andmicrodissectedarcuatearteries(110-130µm)werecannulatedandpressurizedto80mmHg.VesselsweresuperfusedwithKrebssolutioncontainingNG-nitro-L-argininemethylester(L-NAME)andindo...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第7期內傷發熱類型多(三)
4.小柴胡湯合清骨散例陳男,51歲,2004年12月14日就診。主訴:低熱、盜汗1月餘,納寐欠佳,舌淡紅,苔白黃之間,脈細弦。血、尿常規及肝腎功能檢查均無異常。先予補中益氣湯7劑。二診(12月21日):低熱、盜汗依舊。改予當...
中醫中藥;中醫臨牀;臨牀驗案驗案三則
...理反射未引出。舌質紅,苔薄,脈弦細。予當歸15g,川芎12g,白芍12g,熟地12g,天麻12g,鉤藤12g,防風12g,山羊角(先煎)15g,水牛角(先煎)15g,石決明(先煎)20g,木瓜12g,全蠍6g,殭蠶6g,生甘草6g,生大黃(後下)9g,夜...
醫源資料庫;在線期刊;中華中西醫雜誌;2008年第9卷第7期SevereSepsisExacerbatesCell-MediatedImmunityintheLungDuetoanAlteredDendriticCellCytokineProfile
...nophilsthangranulomasinsham-operatedmice.Significantlylowerinterleukin(IL)-12p40mRNAandIL-12p70proteinlevelswereobservedinthelungsofpostsepticmicewithdevelopinggranulomas,comparedwithcontrols.Postsepticmicehadsignificantlyfewerdendriticcellsinthelungsduringthegranulomatousresponse.Isolatedlungdendri...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第6期RoleofNeuronalInterferon-intheDevelopmentofMyelopathyinRatsInfectedwithHumanT-CellLeukemiaVirusType
...fterinfectionappearedtostemfromdefectsinsignalingthroughtheinterleukin(IL)-12receptor.Specifically,WKAH-derivedspinalcordcellswereunabletoup-regulatetheIL-12receptorß2geneinresponsetoIL-12stimulation.WesuggestthatthefailureofspinalcordneuronstoproduceIFN-throughtheIL-12pathwayisinvolvedinthede...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第7期頭痛速愈靈治療頭痛180例療效觀察
...上亢型頭痛13例,肝氣鬱結型頭痛32例,氣血兩虛型頭痛12例,痰濁型頭痛14例。2治療方法採用自擬頭痛速愈靈方,藥物組成:當歸6~12g,川芎10~30g,羌活3~12g,獨活3~12g,蔓荊子6~12g,蒼朮3~10g,麥冬3~10g,黃芩3~10g,菊...
合作平臺;在線期刊;中華現代中西醫雜誌;2004年第2卷第6期;中醫中藥