IntracellularANGIIinducescytosolicCa2+mobilizationbystimulatingintracellularAT1receptorsinproximaltubulecells
...itedarobustincreaseincytoplasmic[Ca2+]ithatpeakedat30s(basal:2.2±0.3vs.ANGII:14.9±0.4relativefluorescenceunits;P0.01).ChelationofextracellularCa2+withEGTA(2mM)didnotaltermicroinjectedANGII-induced[Ca2+]iresponses(Ca2+free+ANGII:12.3±2.6relativefluorescenceunits,notsignificantvs....
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第6期Platelet,NotEndothelial,P-SelectinIsRequiredforNeointimalFormationAfterVascularInjury
...ationintheWTmousegroupwhencomparedwiththePsel–/–mousegroup(0.015±0.004vs0.004±0.004mm2,P0.001).FurthercomparisonshowedsignificantlylessneointimalareainEC-Pselmice(0.006±0.004mm2)comparedwithPlt-Pselmice(0.011±0.005mm2,P=0.026)andWTmice(0.015±0.004mm2,P=0.001).Nosignificantdifferenceswereobs...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第8期LongitudinalFollow-upStudyofSmoker’sLungwithThin-SectionCTinCorrelationwithPulmonaryFunctionTests1
...thegroupofpersistentcurrentsmokers,whoshowedahigherfrequencyofemphysema(40%vs26%;P=.005)andground-glassattenuation(42%vs28%;P=.02).Individualanalysisoffollow-upCTscansinthe19persistentcurrentsmokerswithmicronodulesatT0demonstrated(a)nochangesinsevencases,(b)ahigherprofusionofmicronodulesinsevencases...
醫源資料庫;在線期刊;放射學雜誌;2003年1月第226卷第1期Cyclooxygenase-2inhibitionnormalizesarterialbloodpressureinCYP1A1-REN2transgenicratswithinducibleANGII-dependentmalignanthypertension
...5mg/kgiv).RatsinducedwithI3ChadhigherMAPthannoninducedrats(n=7;188±6vs.136±4mmHg,P0.01).Therewasnodifferenceinrenalplasmaflow(RPF)orglomerularfiltrationrate(GFR)betweeninducedandnoninducedrats.NimesulideelicitedalargerdecreaseinMAPinhypertensiverats(188±6to140±8mmHg,P0.01...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第9期Inflammationandthereciprocalproductionofgranulocytesandlymphocytesinbonemarrow
...ofc-Kitandmorphology,theCD11bintGr-1intpopulationcontainedahighfrequency(24vs.3%)ofproliferatingcells(Fig.1C).Ascontrols,19%ofIgM–B220lopro-/pre-Bcellswereincyclecomparedwith6%inthemature,IgM+B220hipopulation(Fig.1C).Thus,CD11bandGr-1expressionrevealthreeincreasinglymaturegranulocytepopulations.CD...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第11期張錫純腦病學術思想淺析
...確定其爲神明所藏也。”即得出腦藏神明的結論,對於“心主神明”的經典之論,張氏則認爲:“《素問》靈臺祕典曰:‘心者君主之官,神明出焉。’細繹經文,蓋言神明雖藏於腦,而用時實發露於心,故不曰藏而曰出,出者...
中醫中藥;中醫臨牀;臨牀討論Leptinactionintheforebrainregulatesthehindbrainresponsetosatietysignals
...ng,wehousedmalefak/fakratsandtheirlean(Fa/Fa)littermates(bodyweight,494±6gvs.355±6g;P0.05)individuallyinmetaboliccagesequippedtocontinuouslymeasureintakeofstandardchow.Asexpected,thefak/fakanimalsexhibitedamarkedincreaseoffoodintake(by53%)over24hoursrelativetotheFa/Facontrols(32.3±1.9gvs.21.1±0....
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期Long-termtreatmentwithcyclosporinedecreasesaquaporinsandureatransportersintheratkidney
...easedpercentageofTIFinCsA-treatedratscomparedwithVH-treatedrats(23±3vs.0±0%,P<0.001).Fig.1.Trichromestainingofratkidneystreatedwithvehicle(VH;openbar;A)andcyclosporineA(CsA;filledbar;B).CsAtreatmentfor4wkresultedinthedevelopmentoftubulointerstitialfibrosis(TIF)inthecortexassessedbytric...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第7期治療不穩定轉子部骨折的選擇:內固定或關節置換
...心肺功能紊亂的發生率較高,與內固定治療組相比爲(62%vs22%),因此而導致死亡率爲(77%vs35%)。通過上述作者可以看到,關節置換雖然可以避免內固定失敗,可以使患者早期負重,但也會帶來許多的問題。首先,假體方面,單純...
醫源資料庫;在線期刊;中國矯形外科雜誌;2008年第16卷第16期AdvancedGlycosylationEndProductsMightPromoteAtherosclerosisThroughInducingtheImmuneMaturationofDendriticCells
.../mLAGE-BSA(lane4),200μg/mLAGE-BSA(lane5),and300μg/mLAGE-BSA(lane6).*P0.05vs0μg/mLAGE-BSA;P0.05vs200μg/mLBSA;P0.05vs50μg/mLAGE-BSA.Mean±SEM.n=3;(C,D):0hour(lane1),6hours(lane2),12hours(lane3),24hours(lane4),and36hours(lane5).*P0.05vs0hour;P0.05vs6hours;P0.05vs12hours;mean±SEM.n=3;(E,F):control...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第10期